{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,6]],"date-time":"2026-07-06T20:19:39Z","timestamp":1783369179093,"version":"3.54.6"},"reference-count":8,"publisher":"Colegio Mexicano de Inmunologia Clinica y Alergia, A. C.","issue":"4","license":[{"start":{"date-parts":[[2025,12,19]],"date-time":"2025-12-19T00:00:00Z","timestamp":1766102400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Rev Alerg Mex"],"abstract":"<jats:p>ANTECEDENTES\nLa urticaria colin\u00e9rgica (UC) es una enfermedad que afecta 1.5% de la poblaci\u00f3n en Am\u00e9rica Latina. Se ha demostrado que aquellos pacientes con UC tienen 5 veces mayor riesgo de lupus eritematoso sist\u00e9mico (LES).\n\u00a0\nREPORTE DE CASO\nPaciente femenina de 22 a\u00f1os, con antecedente de urticaria colin\u00e9rgica en tratamiento con inmunoterapia sin mejor\u00eda y mejor\u00eda parcial con el uso de antihistam\u00ednicos. Hace 6 meses present\u00f3 cefalea, malestar general, piel seca, habones persistentes y artralgias en falanges distales y rodillas. Se solicitaron los siguientes paracl\u00ednicos: Anti CCP, anti-DNA, B2 glicoprote\u00ednas negativo, antinucleares positivo 1:90 patr\u00f3n nuclear homog\u00e9neo, anticardiolipinas IgG 34, complemento C3-C4 bajo, se diagnostic\u00f3 con LES ya que cumpl\u00eda con 16 puntos de los criterios EULAR, actualmente en tratamiento con cloroquina y prednisona con mejor\u00eda en los s\u00edntomas. Figura 1 \n\u00a0\nDISCUSI\u00d3N\nExisten dos teor\u00edas que pueden explicar la asociaci\u00f3n entre ambas enfermedades, la primera es la inmunopatog\u00e9nesis compartida, se demostr\u00f3 que los pacientes con UC tienen niveles elevados de anti-dsDNA y anti C1q, ambos marcadores espec\u00edficos para LES. Adem\u00e1s el aumento de IgG contra la subunidad \u03b1 de IgE desempe\u00f1a un papel importante en la activaci\u00f3n de mastocitos en la urticaria colin\u00e9rgica y es as\u00ed como desencadena autoinmunidad sist\u00e9mica y progresa a LES m\u00e1s adelante en la vida. Existe un riesgo compartido por HLA-DRB1*04 que se asocia a la presencia tanto de LES como de urticaria colin\u00e9rgica.\n\u00a0\nCONCLUSIONES\nExiste poca informaci\u00f3n en cuanto a la asociaci\u00f3n de estas enfermedades, no se ha determinado un porcentaje de incidencia, sin embargo, se ha demostrado que los pacientes con UC tienen un riesgo significativamente mayor de LES.<\/jats:p>","DOI":"10.29262\/ram.v72i4.1528","type":"journal-article","created":{"date-parts":[[2026,1,7]],"date-time":"2026-01-07T23:39:08Z","timestamp":1767829148000},"page":"397-399","source":"Crossref","is-referenced-by-count":0,"title":["&lt;b&gt;Urticaria colin\u00e9rgica en pacientes con lupus eritematoso sist\u00e9mico \u00bfCoincidencia o conexi\u00f3n inmunol\u00f3gica? &lt;\/b&gt;","&lt;b&gt;Cholinergic urticaria in patients with systemic lupus erythematosus: Coincidence or immunological connection? &lt;\/b&gt;"],"prefix":"10.29262","volume":"72","author":[{"ORCID":"https:\/\/orcid.org\/0009-0007-1896-0869","authenticated-orcid":false,"given":"Cindy Karolina","family":"Moreno Almeida","sequence":"first","affiliation":[{"name":"ISSSTE Valentin Gomez Far\u00edas Zapopan, Jalisco"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-5127-5748","authenticated-orcid":false,"given":"Lucero de Mar\u00eda","family":"Moran Luna","sequence":"additional","affiliation":[{"name":"Hospital Universitario Dr. Joaqu\u00edn del Valle S\u00e1nchez, Torre\u00f3n, Coahuila"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-4059-7398","authenticated-orcid":false,"given":"Luis Angel","family":"Camacho Cruz","sequence":"additional","affiliation":[{"name":"Hospital Universitario Dr. Joaqu\u00edn del Valle S\u00e1nchez, Torre\u00f3n, Coahuila"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-5439-9981","authenticated-orcid":false,"given":"Wendy Alejandra","family":"Casta\u00f1eda Salazar","sequence":"additional","affiliation":[{"name":"Hospital Universitario Dr. Joaqu\u00edn del Valle S\u00e1nchez, Torre\u00f3n, Coahuila"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-0934-8136","authenticated-orcid":false,"given":"Georgina Alejandra","family":"Martinez Morales","sequence":"additional","affiliation":[{"name":"Hospital Universitario Dr. Joaqu\u00edn del Valle S\u00e1nchez, Torre\u00f3n, Coahuila"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-5058-6209","authenticated-orcid":false,"given":"Salvador Antonio","family":"Almanza Luna","sequence":"additional","affiliation":[{"name":"Hospital Universitario Dr. Joaqu\u00edn del Valle S\u00e1nchez, Torre\u00f3n, Coahuila"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"11808","published-online":{"date-parts":[[2025,12,19]]},"reference":[{"key":"65580","doi-asserted-by":"crossref","unstructured":"1. Amaya D, S\u00e1nchez A, S\u00e1nchez J. Urticaria inducible: serie de casos y revisi\u00f3n de la literatura. Biom\u00e9dica 2016; 36 (1): 10-21.","DOI":"10.7705\/biomedica.v36i1.2678"},{"key":"65581","doi-asserted-by":"crossref","unstructured":"2. Fukunaga A, Washio K, Hatakeyama M, Oda Y, Ogura K, et al. Cholinergic urticaria: epidemiology, physiopathology, new categorization, and management. Clin Auton Res 2018; 28 (1): 103-113.","DOI":"10.1007\/s10286-017-0418-6"},{"key":"65582","doi-asserted-by":"crossref","unstructured":"3. Fonseca L, Rodrigues C, Lemos A. Cholinergic Urticaria: A Case Report. Cureus 2022; 14 (10): e30869.","DOI":"10.7759\/cureus.30869"},{"key":"65583","doi-asserted-by":"crossref","unstructured":"4. Zonana-Nacach A, R.-G. L.-B.-C.-d. Factores de riesgo relacionados con lupus eritematoso sist\u00e9mico en poblaci\u00f3n mexicana. 2002. http:\/\/www.insp.mx\/salud\/index.html","DOI":"10.1590\/S0036-36342002000300004"},{"key":"65584","doi-asserted-by":"crossref","unstructured":"5. Palapun-Waitayangkoon1 NC. Increased Risk of Systemic Lupus Erythematosus in Patients with Chronic Urticaria: A Systematic Review and Meta-analysis. Mediterranean J Rheumatol 2023.","DOI":"10.31138\/mjr.34.2.121"},{"key":"65585","doi-asserted-by":"crossref","unstructured":"6. Chien-Hung L. Clinically diagnosed urticaria and risk of systemic lupus erythematosus in children: A nationwide population-based case-control study. Pediatr Allergy Immunol 2018; 29 (7): 32-739. doi: 10.1111\/pai.12962","DOI":"10.1111\/pai.12962"},{"key":"65586","doi-asserted-by":"crossref","unstructured":"7. S\u00e1nchez-Borges M. Caracter\u00edsticas epidemiol\u00f3gicas en pacientes con urticaria cr\u00f3nica espont\u00e1nea resistente al tratamiento con antihistam\u00ednicos. 2015. https:\/\/revistaalergia.mx\/ojs\/index.php\/ram\/article\/view\/130\/254","DOI":"10.29262\/ram.v62i4.130"},{"key":"65587","doi-asserted-by":"crossref","unstructured":"8. Coronado-Bianca OI. Frecuencia y caracterizaci\u00f3n cl\u00ednica de la urticaria cr\u00f3nica en un hospital de tercer nivel. 2021. https:\/\/www.scielo.org.mx\/scielo.php?script=sci_arttext&pid=S2448-91902021000200094","DOI":"10.29262\/ram.v658i2.818"}],"container-title":["Revista Alergia M\u00e9xico"],"original-title":[],"link":[{"URL":"https:\/\/www.revistaalergia.mx\/ojs\/index.php\/ram\/article\/download\/1528\/2804","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.revistaalergia.mx\/ojs\/index.php\/ram\/article\/download\/1528\/2830","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.revistaalergia.mx\/ojs\/index.php\/ram\/article\/download\/1528\/2804","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,6]],"date-time":"2026-07-06T19:51:18Z","timestamp":1783367478000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.revistaalergia.mx\/ojs\/index.php\/ram\/article\/view\/1528"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,12,19]]},"references-count":8,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2025,12,19]]}},"URL":"https:\/\/doi.org\/10.29262\/ram.v72i4.1528","relation":{},"ISSN":["2448-9190","0002-5151"],"issn-type":[{"value":"2448-9190","type":"electronic"},{"value":"0002-5151","type":"print"}],"subject":[],"published":{"date-parts":[[2025,12,19]]}}}