{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,20]],"date-time":"2026-04-20T21:44:58Z","timestamp":1776721498698,"version":"3.51.2"},"reference-count":4,"publisher":"Colegio Mexicano de Inmunologia Clinica y Alergia, A. C.","issue":"1","license":[{"start":{"date-parts":[[2026,3,31]],"date-time":"2026-03-31T00:00:00Z","timestamp":1774915200000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Rev Alerg Mex"],"abstract":"<jats:p>El s\u00edndrome del babuino es una enfermedad extremadamente rara que se caracteriza por erupciones cut\u00e1neas purp\u00faricas bien delimitadas en las \u00e1reas gl\u00fatea e intertriginosa, que se asemejan cl\u00e1sicamente a las de los babuinos de trasero rojo. Adem\u00e1s, se propuso un nuevo acr\u00f3nimo, SDRIFE (exantema intertriginoso y flexural sim\u00e9trico relacionado con f\u00e1rmacos), para definir mejor la enfermedad.\nHombre de 68 a\u00f1os sin antecedentes personales de inter\u00e9s. Acudi\u00f3 a urgencias por dificultad respiratoria aguda y se le administr\u00f3 hidrocortisona parenteral sin incidencias. Se le prescribi\u00f3 deflazacort oral para uso domiciliario. Dos horas despu\u00e9s de la primera tableta, comenz\u00f3 a desarrollar una erupci\u00f3n cut\u00e1nea en la regi\u00f3n inguinal bilateral. Debido a esto, se le aplic\u00f3 diprogenta (betametasona\/gentamicina) en esta zona. Una hora despu\u00e9s de la aplicaci\u00f3n de la crema, la erupci\u00f3n se extendi\u00f3 a la cara interna de ambos muslos y al hipogastrio, acompa\u00f1ada de n\u00e1useas y fiebre de hasta 40 \u00b0C. Fue evaluado en su domicilio y se le administr\u00f3 suero fisiol\u00f3gico y antipir\u00e9ticos, lo que le baj\u00f3 la fiebre. Los s\u00edntomas cut\u00e1neos remitieron gradualmente, dejando una lesi\u00f3n hiperpigmentada residual. Como antecedente, hace 5 a\u00f1os refiri\u00f3 s\u00edntomas urticariales generalizados una hora despu\u00e9s de la administraci\u00f3n de metilprednisolona parenteral.\nSe realizaron pruebas de parche con corticoides resultando positivos para budesonida e hidrocortisona 17-butirato.\nSe realiz\u00f3 una prueba de exposici\u00f3n controlada con deflazacort con buena tolerancia\nDescribimos un caso de posible SDRIFE relacionado con corticosteroides, que involucra diferentes grupos de corticosteroides. Resaltamos la importancia de estudiar a estos pacientes y buscar alternativas a los corticosteroides para su uso posterior, dado su amplio uso en medicina.<\/jats:p>","DOI":"10.29262\/ram.v73i1.1564","type":"journal-article","created":{"date-parts":[[2026,3,31]],"date-time":"2026-03-31T02:42:46Z","timestamp":1774924966000},"page":"105-108","source":"Crossref","is-referenced-by-count":0,"title":["Exantema flexural e intertriginoso sim\u00e9trico en relaci\u00f3n con corticoides."],"prefix":"10.29262","volume":"73","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3147-9774","authenticated-orcid":false,"given":"Lucia","family":"Moreno lozano","sequence":"first","affiliation":[{"name":"Hospital Virgen del Roc\u00edo, Sevilla, Espa\u00f1a."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2613-5566","authenticated-orcid":false,"given":"Teresa","family":"De Aramburu Mera","sequence":"additional","affiliation":[{"name":"Hospital Virgen del Roc\u00edo, Sevilla, Espa\u00f1a.\u00a0"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1978-4787","authenticated-orcid":false,"given":"Carmen","family":"Bermudez Hormigo","sequence":"additional","affiliation":[{"name":"Hospital Virgen del Roc\u00edo, Sevilla, Espa\u00f1a."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"11808","published-online":{"date-parts":[[2026,3,31]]},"reference":[{"key":"67058","doi-asserted-by":"crossref","unstructured":"1. Winnicki M, Shear NH. A systematic approach to systemic contact dermatitis and symmetric drug-related intertriginous and flexural exanthema (SDRIFE): a closer look at these conditions and an approach to intertriginous eruptions. Am J Clin Dermatol. 2011; 12 (3): 171-80. doi: 10.2165\/11539080-000000000-00000.","DOI":"10.2165\/11539080-000000000-00000"},{"key":"67059","doi-asserted-by":"crossref","unstructured":"2. Hausermann P, Harr T, Bircher AJ. Baboon syndrome resulting from systemic drugs: is there strife between SDRIFE and allergic contact dermatitis syndrome? Contact Dermatitis 2004; 51 (5-6): 297-310.","DOI":"10.1111\/j.0105-1873.2004.00445.x"},{"key":"67060","doi-asserted-by":"crossref","unstructured":"3. Bianchi L, Marietti R, Tramontana M, Hansel K, Stingeni L. Systemic allergic dermatitis from intra-articular triamcinolone acetonide: Report of two cases with unusual clinical manifestations. Contact Dermatitis. 2021; 84 (1): 54-56. doi: 10.1111\/cod.13667.","DOI":"10.1111\/cod.13667"},{"key":"67061","doi-asserted-by":"crossref","unstructured":"4. Baeck M, Goossens A. Systemic contact dermatitis to corticosteroids. Allergy 2012; 67: 1580-5.","DOI":"10.1111\/all.12041"}],"container-title":["Revista Alergia M\u00e9xico"],"original-title":[],"link":[{"URL":"https:\/\/www.revistaalergia.mx\/ojs\/index.php\/ram\/article\/download\/1564\/2879","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/revistaalergia.mx\/ojs\/index.php\/ram\/article\/download\/1564\/2855","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.revistaalergia.mx\/ojs\/index.php\/ram\/article\/download\/1564\/2886","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.revistaalergia.mx\/ojs\/index.php\/ram\/article\/download\/1564\/2854","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,20]],"date-time":"2026-04-20T20:57:07Z","timestamp":1776718627000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.revistaalergia.mx\/ojs\/index.php\/ram\/article\/view\/1564"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,3,31]]},"references-count":4,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2026,3,30]]}},"URL":"https:\/\/doi.org\/10.29262\/ram.v73i1.1564","relation":{},"ISSN":["2448-9190","0002-5151"],"issn-type":[{"value":"2448-9190","type":"electronic"},{"value":"0002-5151","type":"print"}],"subject":[],"published":{"date-parts":[[2026,3,31]]}}}