{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,20]],"date-time":"2026-04-20T21:44:55Z","timestamp":1776721495234,"version":"3.51.2"},"reference-count":22,"publisher":"Colegio Mexicano de Inmunologia Clinica y Alergia, A. C.","issue":"1","license":[{"start":{"date-parts":[[2026,3,31]],"date-time":"2026-03-31T00:00:00Z","timestamp":1774915200000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Rev Alerg Mex"],"abstract":"<jats:p>OBJETIVO: Establecer el diagn\u00f3stico de angioedema hereditario mediante estudios de laboratorio y caracterizar a los pacientes con esta enfermedad por primera vez en Paraguay.\nM\u00c9TODOS: Estudio observacional, descriptivo y transversal, emprendido de 2023 a 2024 en pacientes mayores de un a\u00f1o, con s\u00edntomas cl\u00ednicos de angioedema hereditario y familiares asintom\u00e1ticos registrados en la Asociaci\u00f3n AEH-Paraguay, y 20 donadores sanos. Se determin\u00f3 el C1-INH cuantitativo por inmunodifusi\u00f3n radial y C1-INH funcional por ELISA. Se evaluaron caracter\u00edsticas cl\u00ednicas y sociodemogr\u00e1ficas.\nRESULTADOS: Se incluyeron 60 pacientes, 40 conformaron el grupo de estudio (26 con s\u00edntomas cl\u00ednicos de angioedema hereditario y 14 familiares asintom\u00e1ticos) y 20 el de referencia. El 53% (21\/40) fueron mujeres y 15\/40 eran menores de edad (1\u201316 a\u00f1os). Se observaron valores de C1-INH cuantitativo y funcional disminuidos (AEH-1) en 21\/40 pacientes y 4\/40 con C1-INH funcional disminuido (AEH-2). En este grupo (n = 25), 20 ten\u00edan edema y 5 eran familiares asintom\u00e1ticos; adem\u00e1s 6 pacientes de este grupo contaban con diagn\u00f3stico de laboratorio previo y 19 fueron nuevos casos detectados. Los edemas m\u00e1s frecuentes aparecieron en las extremidades, rostro, abdomen y laringe (n = 9). El 56% (14\/25) refiri\u00f3 tener alg\u00fan familiar fallecido con antecedente de edema. El estr\u00e9s y la pubertad fueron los principales factores desencadenantes y la edad de inicio tuvo una mediana de 13 a\u00f1os. Seis pacientes refirieron tratamiento profil\u00e1ctico; las crisis al a\u00f1o reportaron una mediana de 6, y 14 d\u00edas para incapacidad por edema.\nCONCLUSI\u00d3N: Estudiamos el C1-INH en pacientes con edema recurrente y familiares asintom\u00e1ticos, detectando 19 casos nuevos y caracterizando 25 pacientes con angioedema hereditario. Este es el primer abordaje diagn\u00f3stico en Paraguay y reportamos los primeros datos pueden ser \u00fatiles para el sistema de salud p\u00fablica en el desarrollo de pol\u00edticas que contemplen el diagn\u00f3stico y tratamiento de pacientes con angioedema hereditario.\nPALABRAS CLAVE: Paraguay; Angioedema hereditario; Prote\u00edna C1-INH; Edema; Diagn\u00f3stico; ELISA; Salud p\u00fablica.<\/jats:p>","DOI":"10.29262\/ram.v73i1.1570","type":"journal-article","created":{"date-parts":[[2026,3,31]],"date-time":"2026-03-31T02:38:45Z","timestamp":1774924725000},"page":"40-47","source":"Crossref","is-referenced-by-count":0,"title":["&lt;b&gt;Detecci\u00f3n de angioedema hereditario: primer abordaje de diagn\u00f3stico por estudios de laboratorio y caracterizaci\u00f3n de pacientes en Paraguay&lt;\/b&gt;","&lt;b&gt;Detection of hereditary angioedema: first approach to laboratory diagnosis and patient characterization in Paraguay&lt;\/b&gt;"],"prefix":"10.29262","volume":"73","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3287-4717","authenticated-orcid":false,"given":"Diana","family":"Sanabria Mart\u00ednez","sequence":"first","affiliation":[{"name":"Instituto de Investigaciones en Ciencias de la Salud, Universidad Nacional de Asunci\u00f3n, San Lorenzo, Paraguay."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0270-2837","authenticated-orcid":false,"given":"Sara","family":"Benegas","sequence":"additional","affiliation":[{"name":"Instituto de Investigaciones en Ciencias de la Salud, Universidad Nacional de Asunci\u00f3n, San Lorenzo, Paraguay."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2575-3079","authenticated-orcid":false,"given":"Ana","family":"Godoy","sequence":"additional","affiliation":[{"name":"Instituto de Investigaciones en Ciencias de la Salud, Universidad Nacional de Asunci\u00f3n, San Lorenzo, Paraguay."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1013-3942","authenticated-orcid":false,"given":"Vivian","family":"Gim\u00e9nez","sequence":"additional","affiliation":[{"name":"Instituto de Investigaciones en Ciencias de la Salud, Universidad Nacional de Asunci\u00f3n, San Lorenzo, Paraguay."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"11808","published-online":{"date-parts":[[2026,3,31]]},"reference":[{"key":"66954","doi-asserted-by":"crossref","unstructured":"1. Maurer M, Magerl M, Betschel S, et al. The international WAO\/EAACI guideline for the management of hereditary angioedema\u2014The 2021 revision and update. Eur J Allergy Clin Immunol. 2022; 77 (7): 1961-1990. doi:10.1111\/all.15214","DOI":"10.1111\/all.15214"},{"key":"66955","doi-asserted-by":"crossref","unstructured":"2. de Maat S, Joseph K, Maas C, Kaplan AP. Blood Clotting and the Pathogenesis of Types I and II Hereditary Angioedema. Clin Rev Allergy Immunol. 2021; 60 (3): 348-356. doi:10.1007\/s12016-021-08837-6","DOI":"10.1007\/s12016-021-08837-6"},{"key":"66956","doi-asserted-by":"crossref","unstructured":"3. Maas C, L\u00f3pez-Lera A. Hereditary Angioedema: Insights into inflammation and allergy. Mol Immunol. 2019; 112: 378-386. doi:10.1016\/j.molimm.2019.06.017","DOI":"10.1016\/j.molimm.2019.06.017"},{"key":"66957","doi-asserted-by":"crossref","unstructured":"4. Cicardi M, Zuraw BL. Angioedema Due to Bradykinin Dysregulation. 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