{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,6]],"date-time":"2026-07-06T20:21:28Z","timestamp":1783369288377,"version":"3.54.6"},"reference-count":0,"publisher":"Colegio Mexicano de Inmunologia Clinica y Alergia, A. C.","issue":"2","license":[{"start":{"date-parts":[[2026,6,30]],"date-time":"2026-06-30T00:00:00Z","timestamp":1782777600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Rev Alerg Mex"],"abstract":"<jats:p>OBJETIVO: Evaluar la asociaci\u00f3n de los polimorfismos del promotor del TNF-\u03b1 (rs361525, rs1800629) y la variante PTPN22 rs2476601 con la coexistencia de urticaria cr\u00f3nica espont\u00e1nea (UCE) y tiroiditis de Hashimoto (TH) en una poblaci\u00f3n mixta caribe\u00f1a colombiana.\nM\u00c9TODOS: Estudio retrospectivo de casos y controles, llevado a cabo en 86 pacientes con UCE confirmada (45 con UCE sola y 41 con UCE+TH). Se realiz\u00f3 la genotipificaci\u00f3n de polimorfismos de un solo nucle\u00f3tido (SNP) mediante ensayos TaqMan\u00ae. El equilibrio de Hardy-Weinberg (EHW), los genotipos y las frecuencias al\u00e9licas se analizaron mediante pruebas de chi-cuadrado y modelos de regresi\u00f3n log\u00edstica.\nRESULTADOS: El alelo G de PTPN22 mostr\u00f3 una asociaci\u00f3n protectora en el grupo UCE+TH (OR: 0,02; IC del 95%: 0,00\u20130,49; p = 0,015). Si bien los SNP de TNF-\u03b1 se ajustaron al equilibrio de Hardy-Weinberg (EHW), el PTPN22 present\u00f3 desviaciones en el grupo CSU+HT debido a la ausencia total de heterocigotos AG. No se encontr\u00f3 asociaci\u00f3n significativa entre los polimorfismos de TNF-\u03b1 y la HT, aunque el alelo G del TNF-\u03b1 rs361525 mostr\u00f3 una tendencia casi significativa (p = 0.061). El genotipo GG fue predominante en todos los SNP evaluados.\nCONCLUSIONES: En este estudio con poblaci\u00f3n mixta caribe\u00f1a colombiana se encontr\u00f3 una asociaci\u00f3n que genera hip\u00f3tesis entre el alelo G del PTPN22 rs2476601 y una menor probabilidad de HT concomitante en pacientes con CSU. Se requieren estudios m\u00e1s amplios y con suficiente potencia estad\u00edstica, que incorporen un ajuste riguroso de la ascendencia, para confirmar este hallazgo.\nPALABRAS CLAVE: Caribe Colombiano; Urticaria espont\u00e1nea cr\u00f3nica; TNF-\u03b1; PTPN22; Polimorfismos del promotor; Tiroiditis de Hashimoto; Alelo.\n\u00a0<\/jats:p>","DOI":"10.29262\/ram.v73i2.1585","type":"journal-article","created":{"date-parts":[[2026,7,6]],"date-time":"2026-07-06T19:57:50Z","timestamp":1783367870000},"page":"111-119","source":"Crossref","is-referenced-by-count":0,"title":["&lt;b&gt;Variantes gen\u00e9ticas del TNF-\u03b1 y PTPN22 y su relaci\u00f3n con tiroiditis de Hashimoto en pacientes con urticaria cr\u00f3nica espont\u00e1nea del Caribe Colombiano&lt;\/b&gt;","&lt;b&gt;Genetic variants of &lt;i&gt;TNF-\u03b1&lt;\/i&gt; and &lt;i&gt;PTPN22&lt;\/i&gt; and their association with Hashimoto\u2019s thyroiditis in patients with chronic spontaneous urticaria from the Colombian Caribbean.&lt;\/b&gt;"],"prefix":"10.29262","volume":"73","author":[{"given":"Carlos octavio","family":"Arroyo Movilla","sequence":"first","affiliation":[{"name":"UNIVERSIDAD DEL NORTE"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alex","family":"Dom\u00ednguez Vargas","sequence":"additional","affiliation":[{"name":"UNIVERSIDAD DEL NORTE"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luis","family":"Fang","sequence":"additional","affiliation":[{"name":"UNIVERSIDAD DEL NORTE"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana","family":"Moreno Woo","sequence":"additional","affiliation":[{"name":"UNIVERSIDAD DEL NORTE"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gloria","family":"Garavito de Egea","sequence":"additional","affiliation":[{"name":"UNIVERSIDAD DEL NORTE"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eduardo","family":"Egea Bermejo","sequence":"additional","affiliation":[{"name":"UNIVERSIDAD DEL NORTE"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"11808","published-online":{"date-parts":[[2026,6,30]]},"container-title":["Revista Alergia M\u00e9xico"],"original-title":[],"link":[{"URL":"https:\/\/revistaalergia.mx\/ojs\/index.php\/ram\/article\/download\/1585\/2888","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/revistaalergia.mx\/ojs\/index.php\/ram\/article\/download\/1585\/2888","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,6]],"date-time":"2026-07-06T19:57:51Z","timestamp":1783367871000},"score":1,"resource":{"primary":{"URL":"https:\/\/revistaalergia.mx\/ojs\/index.php\/ram\/article\/view\/1585"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,6,30]]},"references-count":0,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2026,6,30]]}},"URL":"https:\/\/doi.org\/10.29262\/ram.v73i2.1585","relation":{},"ISSN":["2448-9190","0002-5151"],"issn-type":[{"value":"2448-9190","type":"electronic"},{"value":"0002-5151","type":"print"}],"subject":[],"published":{"date-parts":[[2026,6,30]]}}}