{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,14]],"date-time":"2026-04-14T04:56:44Z","timestamp":1776142604360,"version":"3.50.1"},"reference-count":20,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023]]},"abstract":"<jats:sec>\n            <jats:title>Background:<\/jats:title>\n            <jats:p>Prolonged post-operative ileus is associated with increased risk of other complications, length of hospital stays and health care related costs. Chewing gum has been shown to reduce duration of ileus in many elective surgeries, but there is a paucity of randomised controlled trials (RCTs) on its effect on duration of ileus among patients undergoing emergency surgery, specifically patients with peritonitis. The aim of this study is to determine the effect of chewing gum on duration of postoperative ileus following laparotomy for gastroduodenal perforations.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Methods:<\/jats:title>\n            <jats:p>This will be a randomised controlled trial done in 3 hospitals. Fifty-two patients will be randomised to 2 groups. Group A will receive chewing gum in addition to routine care, whereas group B will receive routine care only. The duration of post-operative ileus in the two groups which is the primary outcome, will be compared using the independent samples t-test in SPSS version 22. The length of hospital stay, in-hospital morbidity and mortality will be the secondary outcomes. This trial has been approved by Kampala International University research and Ethics committee (Ref No. <jats:bold>KIU-2021-60<\/jats:bold>) and Uganda national council of science and technology (Ref No. <jats:bold>HS1665ES<\/jats:bold>). Retrospective registration with the research registry has also been done (UIN: researchregistry8565).<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Highlights<\/jats:title>\n          <\/jats:sec>","DOI":"10.29337\/ijsp.188","type":"journal-article","created":{"date-parts":[[2023,2,7]],"date-time":"2023-02-07T04:35:57Z","timestamp":1675744557000},"page":"9-17","source":"Crossref","is-referenced-by-count":9,"title":["Effect of Chewing Gum on Duration of Postoperative Ileus Following Laparotomy for Gastroduodenal Perforations: Protocol for a Randomized Controlled Trial"],"prefix":"10.1097","volume":"27","author":[{"given":"Joshua","family":"Muhumuza","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Selamo Fabrice","family":"Molen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"William","family":"Mauricio","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jorge Soria","family":"La O","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jethro","family":"Atumanyire","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nyenke Bassara","family":"Godefroy","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Musa Abbas","family":"Waziri","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stephen Mbae","family":"Kithinji","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kiyaka Magugu","family":"Sonye","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mugisho Munyerenkana","family":"Leocadie","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Franck Katembo","family":"Sikakulya","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"ByaMungu Pahari","family":"Kagenderezo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Musafiri Simba","family":"Lionel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mumin","family":"Farah","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Herman","family":"Lule","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"276","reference":[{"issue":"3","key":"R2-2-20231013","doi-asserted-by":"crossref","first-page":"508","DOI":"10.1007\/s11605-017-3622-8","article-title":"Perioperative factors predicting prolonged postoperative ileus after major abdominal surgery","volume":"22","author":"Sugawara","year":"2018","journal-title":"J. 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Res"},{"issue":"2","key":"R20-2-20231013","doi-asserted-by":"crossref","first-page":"109","DOI":"10.22442\/jlumhs.191820611","article-title":"Chewing aid in routine postoperative orders-does it reduce postoperative ileus after cesarean section? A randomized control trial","volume":"18","author":"Ali","year":"2019","journal-title":"J. Liaquat Univ. Med. Heal. Sci"},{"issue":"2","key":"R21-2-20231013","doi-asserted-by":"crossref","first-page":"147","DOI":"10.11569\/wcjd.v25.i2.147","article-title":"Gum chewing for promoting intestinal function recovery after colorectal cancer surgery: A meta-analysis","volume":"25","author":"ZunJia","year":"2017","journal-title":"World Chinese J. 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Doct"},{"issue":"8","key":"R26-2-20231013","doi-asserted-by":"crossref","first-page":"672","DOI":"10.1016\/j.ijsu.2011.09.004","article-title":"CONSORT 2010 statement: Updated guidelines for reporting parallel group randomised trials","volume":"9","author":"Schulz","year":"2011","journal-title":"Int. J. Surg"},{"issue":"1","key":"R27-2-20231013","first-page":"51","article-title":"How to calculate sample size in randomized controlled trial?","volume":"1","author":"Zhong","year":"2009","journal-title":"J. Thorac. Dis"},{"issue":"1","key":"R28-2-20231013","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s13104-015-0996-0","article-title":"Effects of chewing gum against postoperative ileus after pancreaticoduodenectomy \u2013 A randomized controlled trial","volume":"8","author":"Andersson","year":"2015","journal-title":"BMC Res. Notes"},{"issue":"6","key":"R29-2-20231013","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1093\/bjs\/znac052","article-title":"Core outcome set for clinical studies of postoperative ileus after intestinal surgery","volume":"109","year":"2022","journal-title":"Br. J. Surg"},{"issue":"2","key":"R30-2-20231013","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1097\/01.sla.0000133083.54934.ae","article-title":"Classification of surgical complications: A new proposal with evaluation in a cohort of 6336 patients and results of a survey","volume":"240","author":"Dindo","year":"2004","journal-title":"Annals of Surgery"}],"container-title":["International Journal of Surgery Protocols"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.lww.com\/10.29337\/ijsp.188","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,13]],"date-time":"2023-10-13T16:00:56Z","timestamp":1697212856000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.lww.com\/10.29337\/ijsp.188"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023]]},"references-count":20,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2023]]}},"URL":"https:\/\/doi.org\/10.29337\/ijsp.188","relation":{},"ISSN":["2468-3574"],"issn-type":[{"value":"2468-3574","type":"print"}],"subject":[],"published":{"date-parts":[[2023]]}}}