{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T19:03:13Z","timestamp":1787166193079,"version":"build-2736575974"},"reference-count":37,"publisher":"Canadian Society of Respiratory Therapists","license":[{"start":{"date-parts":[[2025,5,13]],"date-time":"2025-05-13T00:00:00Z","timestamp":1747094400000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"abstract":"<jats:sec id=\"introduction\">\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Adequate respiratory support with mechanical lung ventilation (MLV) is crucial for maintaining gas exchange and pulmonary circulation hemodynamics in patients with severe lung diseases in the perioperative period. However, the selection of optimal parameters for ventilation is often a serious problem, which can lead to the development of complications and worsening of treatment outcomes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"purpose\">\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>This study aimed to evaluate the effectiveness of the developed method of individual calculation of ventilator parameters to optimize respiratory support in patients with various lung diseases undergoing surgical intervention.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"methods\">\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This study used a prospective clinical approach to optimize mechanical lung ventilation by calculating individualized ventilatory parameters based on each patient\u2019s lung function during surgery.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"results\">\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The results showed that in patients with unilateral lesions, the application of the developed method achieved PaO2 94.1\u00b16.7 mmHg and PaCO2 36.2\u00b14.5 mmHg, mean pulmonary artery pressure 25.8\u00b13.6 mmHg, as well as cardiac output 4.8\u00b10.8 l\/min and oxygen transport 489\u00b177 ml\/min at the final post-operative stage. Even in bilateral diffuse lesions, individualized ventilatory parameters provided PaO2 79.6\u00b111.3 mmHg and reduced bronchial resistance to 11.4\u00b13.6 cmH2O\/l\/sec after surgery. Despite gross respiratory dysfunction, the personalized approach maintained PaO2 79.2\u00b19.7 mmHg and PaCO2 46.1\u00b16.3 mmHg postoperatively in patients with congenital pulmonary malformations such as cystic hypoplasia.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"conclusion\">\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>This study demonstrates the high efficacy of personalized approaches to respiratory support management to improve patient outcomes and reduce the risk of complications in patients with lung disease in the perioperative period.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.29390\/001c.137289","type":"journal-article","created":{"date-parts":[[2025,5,13]],"date-time":"2025-05-13T12:40:03Z","timestamp":1747140003000},"source":"Crossref","is-referenced-by-count":1,"title":["Individualized parameters for mechanical ventilation during thoracic operations: Optimizing respiratory support"],"prefix":"10.29390","volume":"61","author":[{"given":"Mukhtar","family":"Batyrkhanov","sequence":"first","affiliation":[{"name":"Kazakh-Russian Medical University","department":["Department of Surgery with Courses In Reanimatology and Anesthesiology"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dilyara","family":"Mukhtarkhanova","sequence":"additional","affiliation":[{"name":"Asfendiyarov Kazakh National Medical University","department":["Department of Cardiology"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"11956","published-online":{"date-parts":[[2025,5,13]]},"reference":[{"issue":"2","key":"ref1","doi-asserted-by":"publisher","first-page":"113","DOI":"10.5455\/aim.2015.23.113-115","article-title":"Bathing epilepsy: Report of three Caucasian cases","volume":"23","author":"F. 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