{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T21:02:31Z","timestamp":1791061351405,"version":"4.1.0"},"reference-count":41,"publisher":"Society of Nuclear Medicine","issue":"9","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Nucl Med"],"published-print":{"date-parts":[[2010,9]]},"DOI":"10.2967\/jnumed.110.075861","type":"journal-article","created":{"date-parts":[[2010,8,19]],"date-time":"2010-08-19T02:15:31Z","timestamp":1282184131000},"page":"1377-1385","source":"Crossref","is-referenced-by-count":211,"title":["Efficacy and Toxicity Related to Treatment of Hepatocellular Carcinoma with <sup>90<\/sup>Y-SIR Spheres: Radiobiologic Considerations"],"prefix":"10.2967","volume":"51","author":[{"given":"Lidia","family":"Strigari","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rosa","family":"Sciuto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sandra","family":"Rea","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Livio","family":"Carpanese","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giuseppe","family":"Pizzi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonella","family":"Soriani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giuseppe","family":"Iaccarino","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcello","family":"Benassi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giuseppe Maria","family":"Ettorre","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlo Ludovico","family":"Maini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1602","published-online":{"date-parts":[[2010,8,18]]},"reference":[{"key":"2021051712005077000_51.9.1377.1","doi-asserted-by":"publisher","DOI":"10.1159\/000050693"},{"key":"2021051712005077000_51.9.1377.2","doi-asserted-by":"crossref","first-page":"390","DOI":"10.7326\/0003-4819-108-3-390","article-title":"NIH conference: hepatocellular cancer","volume":"108","author":"Di Bisceglie","year":"1988","journal-title":"Ann Intern Med."},{"key":"2021051712005077000_51.9.1377.3","doi-asserted-by":"crossref","first-page":"S319","DOI":"10.1111\/j.1440-1746.1997.tb00516.x","article-title":"Non-surgical treatment of hepatocellular carcinoma","volume":"12","author":"Lin","year":"1997","journal-title":"J Gastroenterol Hepatol."},{"key":"2021051712005077000_51.9.1377.4","doi-asserted-by":"publisher","DOI":"10.1016\/S0167-8140(02)00061-0"},{"key":"2021051712005077000_51.9.1377.5","doi-asserted-by":"publisher","DOI":"10.1016\/S0360-3016(00)00519-8"},{"key":"2021051712005077000_51.9.1377.6","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2006.11.060"},{"key":"2021051712005077000_51.9.1377.7","doi-asserted-by":"publisher","DOI":"10.1088\/0031-9155\/41\/10\/001"},{"key":"2021051712005077000_51.9.1377.8","doi-asserted-by":"publisher","DOI":"10.1089\/cbr.2005.20.47"},{"key":"2021051712005077000_51.9.1377.9","doi-asserted-by":"publisher","DOI":"10.1118\/1.2198189"},{"key":"2021051712005077000_51.9.1377.10","unstructured":"Sirtex Medical Limited. SIR-Spheres Training Program, Physicians and Institutions. Available at: http:\/\/www.sirtex.com\/files\/TRN-US-0320for20US1.pdf. Accessed August 3, 2010."},{"key":"2021051712005077000_51.9.1377.11","doi-asserted-by":"publisher","DOI":"10.1118\/1.2266255"},{"key":"2021051712005077000_51.9.1377.12","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/92.3.205"},{"key":"2021051712005077000_51.9.1377.13","doi-asserted-by":"publisher","DOI":"10.1016\/S0168-8278(01)00130-1"},{"key":"2021051712005077000_51.9.1377.14","unstructured":"Jakobs T . Radiologic follow-up of patients treated with SIRT. Paper presented at: Liver-Directed Radiotherapy with Microspheres: A Clinical Symposium; February 11\u201312, 2006; Barcelona, Spain."},{"key":"2021051712005077000_51.9.1377.15","doi-asserted-by":"publisher","DOI":"10.1007\/s00259-008-0857-3"},{"key":"2021051712005077000_51.9.1377.16","doi-asserted-by":"publisher","DOI":"10.1097\/01.coc.0000236210.41199.91"},{"key":"2021051712005077000_51.9.1377.17","doi-asserted-by":"publisher","DOI":"10.1088\/0031-9155\/53\/19\/001"},{"key":"2021051712005077000_51.9.1377.18","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1016\/S0167-8140(83)80021-8","article-title":"A new isoeffect curve for change in dose per fraction","volume":"1","author":"Withers","year":"1983","journal-title":"Radiother Oncol."},{"key":"2021051712005077000_51.9.1377.19","doi-asserted-by":"publisher","DOI":"10.1016\/S0360-3016(02)02846-8"},{"key":"2021051712005077000_51.9.1377.20","doi-asserted-by":"crossref","first-page":"1454","DOI":"10.1016\/j.ijrobp.2008.07.024","article-title":"A mathematical model for evaluating the incidence of acute rectal toxicity during conventional or hypo-fractionated radiotherapy courses for prostate cancer","volume":"73","author":"Strigari","year":"2009","journal-title":"Int J Radiat Oncol Biol Phys."},{"key":"2021051712005077000_51.9.1377.21","doi-asserted-by":"publisher","DOI":"10.2307\/2533958"},{"key":"2021051712005077000_51.9.1377.22","unstructured":"Child CG Turcotte JG . Surgery and portal hypertension. In: Child CG , ed. The Liver and Portal Hypertension. Philadelphia, PA: Saunders; 1964:50\u201364."},{"key":"2021051712005077000_51.9.1377.23","doi-asserted-by":"publisher","DOI":"10.1088\/0031-9155\/53\/20\/008"},{"key":"2021051712005077000_51.9.1377.24","doi-asserted-by":"crossref","first-page":"1085","DOI":"10.1097\/01.RVI.0000177063.92678.21","article-title":"The effect of catheter directed CT angiography on yttrium-90 radioembolization treatment of hepatocellular carcinoma","volume":"16","author":"Rhee","year":"2005","journal-title":"J Vasc Interv Radiol."},{"key":"2021051712005077000_51.9.1377.25","doi-asserted-by":"publisher","DOI":"10.1016\/0360-3016(95)00039-3"},{"key":"2021051712005077000_51.9.1377.26","doi-asserted-by":"publisher","DOI":"10.1097\/01.RVI.00001142592.89564.F9"},{"key":"2021051712005077000_51.9.1377.27","first-page":"351","article-title":"Extra-hepatic embolisation of Y-90 microspheres from selective internal radiation therapy (SIRT) of the liver","volume":"35","author":"Thamboo","year":"2003","journal-title":"Pathology."},{"key":"2021051712005077000_51.9.1377.28","doi-asserted-by":"publisher","DOI":"10.1007\/BF01084369"},{"key":"2021051712005077000_51.9.1377.29","first-page":"200","article-title":"Radiation hepatitis","volume":"93","author":"Ingold","year":"1965","journal-title":"AJR."},{"key":"2021051712005077000_51.9.1377.30","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1016\/0360-3016(91)90171-Y","article-title":"Tolerance of normal tissue to therapeutic irradiation","volume":"21","author":"Emami","year":"1991","journal-title":"Int J Radiat Oncol Biol Phys."},{"key":"2021051712005077000_51.9.1377.31","doi-asserted-by":"publisher","DOI":"10.1002\/jso.2930420313"},{"key":"2021051712005077000_51.9.1377.32","doi-asserted-by":"crossref","first-page":"994","DOI":"10.1038\/bjc.1994.436","article-title":"Treatment of inoperative hepatocellular carcinoma with intra-arterial yttrium-90 microspheres: a phase 1 and 2 study","volume":"70","author":"Lau","year":"1994","journal-title":"Br J Cancer."},{"key":"2021051712005077000_51.9.1377.33","doi-asserted-by":"publisher","DOI":"10.1016\/0277-5379(89)90109-0"},{"key":"2021051712005077000_51.9.1377.34","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19880401)61:7<1336::AID-CNCR2820610711>3.0.CO;2-K"},{"key":"2021051712005077000_51.9.1377.35","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2005.11.034"},{"key":"2021051712005077000_51.9.1377.36","first-page":"1673","article-title":"Treatment of nonresectable hepatocellular carcinoma with intrahepatic 90Y-microspheres","volume":"41","author":"Dancey","year":"2000","journal-title":"J Nucl Med."},{"key":"2021051712005077000_51.9.1377.37","doi-asserted-by":"publisher","DOI":"10.1002\/hep.20465"},{"key":"2021051712005077000_51.9.1377.38","doi-asserted-by":"publisher","DOI":"10.2214\/AJR.06.0706"},{"key":"2021051712005077000_51.9.1377.39","doi-asserted-by":"crossref","first-page":"800","DOI":"10.1016\/j.ijrobp.2007.03.056","article-title":"Use of yttrium-90 microspheres in the treatment of unresectable hepatic metastases from breast cancer","volume":"69","author":"Coldwell","year":"2007","journal-title":"Int J Radiat Oncol Biol Phys."},{"key":"2021051712005077000_51.9.1377.40","doi-asserted-by":"publisher","DOI":"10.1016\/0360-3016(89)90972-3"},{"key":"2021051712005077000_51.9.1377.41","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1016\/0360-3016(89)90462-8","article-title":"Optimization of radiation therapy IV: a dose-volume histogram reduction algorithm","volume":"17","author":"Lyman","year":"1989","journal-title":"Int J Radiat Oncol Biol Phys."}],"container-title":["Journal of Nuclear Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.2967\/jnumed.110.075861","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,5,17]],"date-time":"2021-05-17T19:26:42Z","timestamp":1621279602000},"score":1,"resource":{"primary":{"URL":"http:\/\/jnm.snmjournals.org\/lookup\/doi\/10.2967\/jnumed.110.075861"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,8,18]]},"references-count":41,"journal-issue":{"issue":"9","published-online":{"date-parts":[[2010,9,1]]},"published-print":{"date-parts":[[2010,9]]}},"alternative-id":["10.2967\/jnumed.110.075861"],"URL":"https:\/\/doi.org\/10.2967\/jnumed.110.075861","relation":{},"ISSN":["0161-5505","2159-662X"],"issn-type":[{"value":"0161-5505","type":"print"},{"value":"2159-662X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2010,8,18]]}}}