{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,19]],"date-time":"2026-02-19T06:26:27Z","timestamp":1771482387504,"version":"3.50.1"},"reference-count":33,"publisher":"Society of Nuclear Medicine","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Nucl Med"],"published-print":{"date-parts":[[2015,2]]},"DOI":"10.2967\/jnumed.114.147488","type":"journal-article","created":{"date-parts":[[2015,1,16]],"date-time":"2015-01-16T03:59:56Z","timestamp":1421380796000},"page":"317-322","source":"Crossref","is-referenced-by-count":18,"title":["<sup>123<\/sup>I-Iododexetimide Preferentially Binds to the Muscarinic Receptor Subtype M<sub>1<\/sub>In Vivo"],"prefix":"10.2967","volume":"56","author":[{"given":"Geor","family":"Bakker","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wilhelmina A.","family":"Vingerhoets","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jan\u2013Peter van","family":"Wieringen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kora","family":"de Bruin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jos","family":"Eersels","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jan","family":"de Jong","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Youssef","family":"Chahid","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bart P.","family":"Rutten","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Susan","family":"DuBois","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Megan","family":"Watson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Adrian J.","family":"Mogg","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hongling","family":"Xiao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael","family":"Crabtree","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David A.","family":"Collier","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christian C.","family":"Felder","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vanessa N.","family":"Barth","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lisa M.","family":"Broad","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Oswald J.","family":"Bloemen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Th\u00e9r\u00e8se A.","family":"van Amelsvoort","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jan","family":"Booij","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1602","published-online":{"date-parts":[[2015,1,15]]},"reference":[{"key":"2021051712071750000_56.2.317.1","doi-asserted-by":"publisher","DOI":"10.1016\/S0891-0618(03)00068-1"},{"key":"2021051712071750000_56.2.317.2","doi-asserted-by":"crossref","unstructured":"Birks J . Cholinesterase inhibitors for Alzheimer\u2019s disease. Cochrane Database Syst Rev. 2006;CD005593.","DOI":"10.1002\/14651858.CD005593"},{"key":"2021051712071750000_56.2.317.3","doi-asserted-by":"crossref","first-page":"55","DOI":"10.3389\/fncel.2013.00055","article-title":"Cholinergic connectivity: its implications for psychiatric disorders","volume":"7","author":"Scarr","year":"2013","journal-title":"Front Cell Neurosci."},{"key":"2021051712071750000_56.2.317.4","doi-asserted-by":"crossref","unstructured":"McKinzie DL Bymaster FP . Muscarinic mechanisms in psychotic disorders. Handb Exp Pharmacol. 2012:233\u2013265.","DOI":"10.1007\/978-3-642-25758-2_9"},{"key":"2021051712071750000_56.2.317.5","doi-asserted-by":"publisher","DOI":"10.1016\/j.drudis.2013.09.005"},{"key":"2021051712071750000_56.2.317.6","doi-asserted-by":"publisher","DOI":"10.1176\/appi.ajp.2008.06091591"},{"key":"2021051712071750000_56.2.317.7","doi-asserted-by":"publisher","DOI":"10.1016\/0306-4522(87)90006-6"},{"key":"2021051712071750000_56.2.317.8","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0900903106"},{"key":"2021051712071750000_56.2.317.9","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.3930-09.2009"},{"key":"2021051712071750000_56.2.317.10","doi-asserted-by":"publisher","DOI":"10.1017\/S1461145712000752"},{"key":"2021051712071750000_56.2.317.11","doi-asserted-by":"crossref","first-page":"1148","DOI":"10.1016\/S0022-3565(25)23162-7","article-title":"Regional distribution of M1, M2 and non-M1, non-M2 subtypes of muscarinic binding sites in rat brain","volume":"255","author":"Ehlert","year":"1990","journal-title":"J Pharmacol Exp Ther."},{"key":"2021051712071750000_56.2.317.12","doi-asserted-by":"publisher","DOI":"10.1016\/0024-3205(87)90031-2"},{"key":"2021051712071750000_56.2.317.13","doi-asserted-by":"crossref","first-page":"1888","DOI":"10.1046\/j.1471-4159.1995.64041888.x","article-title":"Differential regulation of molecular subtypes of muscarinic receptors in Alzheimer\u2019s disease","volume":"64","author":"Flynn","year":"1995","journal-title":"J Neurochem."},{"key":"2021051712071750000_56.2.317.14","doi-asserted-by":"publisher","DOI":"10.1038\/nn992"},{"key":"2021051712071750000_56.2.317.15","doi-asserted-by":"publisher","DOI":"10.1016\/j.tics.2006.09.005"},{"key":"2021051712071750000_56.2.317.16","doi-asserted-by":"publisher","DOI":"10.1007\/s00213-011-2171-1"},{"key":"2021051712071750000_56.2.317.17","doi-asserted-by":"publisher","DOI":"10.1021\/jm00125a021"},{"key":"2021051712071750000_56.2.317.18","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-4159.1979.tb00366.x"},{"key":"2021051712071750000_56.2.317.19","first-page":"1332","article-title":"Human dosimetry and biodistribution of iodine-123-iododexetimide: a SPECT imaging agent for cholinergic muscarinic neuroreceptors","volume":"36","author":"Boundy","year":"1995","journal-title":"J Nucl Med."},{"key":"2021051712071750000_56.2.317.20","doi-asserted-by":"publisher","DOI":"10.1038\/jcbfm.1992.80"},{"key":"2021051712071750000_56.2.317.21","doi-asserted-by":"publisher","DOI":"10.1016\/0006-2952(73)90196-2"},{"key":"2021051712071750000_56.2.317.22","doi-asserted-by":"publisher","DOI":"10.1007\/BF00169040"},{"key":"2021051712071750000_56.2.317.23","doi-asserted-by":"publisher","DOI":"10.1016\/S0920-9964(98)00146-7"},{"key":"2021051712071750000_56.2.317.24","doi-asserted-by":"publisher","DOI":"10.1007\/s002130000679"},{"key":"2021051712071750000_56.2.317.25","doi-asserted-by":"publisher","DOI":"10.1016\/j.jneumeth.2007.10.028"},{"key":"2021051712071750000_56.2.317.26","doi-asserted-by":"publisher","DOI":"10.2967\/jnumed.113.132340"},{"key":"2021051712071750000_56.2.317.27","doi-asserted-by":"publisher","DOI":"10.1016\/j.nucmedbio.2011.11.006"},{"key":"2021051712071750000_56.2.317.28","doi-asserted-by":"publisher","DOI":"10.1016\/j.jocn.2004.06.012"},{"key":"2021051712071750000_56.2.317.29","first-page":"602","article-title":"Demonstration of a reduction in muscarinic receptor binding in early Alzheimer\u2019s disease using iodine-123 dexetimide single-photon emission tomography","volume":"24","author":"Claus","year":"1997","journal-title":"Eur J Nucl Med."},{"key":"2021051712071750000_56.2.317.30","first-page":"L103","article-title":"Age-related changes in pulmonary muscarinic receptor binding properties","volume":"265","author":"Wills-Karp","year":"1993","journal-title":"Am J Physiol."},{"key":"2021051712071750000_56.2.317.31","doi-asserted-by":"publisher","DOI":"10.1038\/sj.npp.1300027"},{"key":"2021051712071750000_56.2.317.32","doi-asserted-by":"crossref","first-page":"985","DOI":"10.1017\/S1092852900014048","article-title":"Muscarinic agonists for the treatment of cognition in schizophrenia","volume":"13","author":"Sellin","year":"2008","journal-title":"CNS Spectr."},{"key":"2021051712071750000_56.2.317.33","doi-asserted-by":"publisher","DOI":"10.1016\/j.mad.2005.09.024"}],"container-title":["Journal of Nuclear Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.2967\/jnumed.114.147488","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,5,16]],"date-time":"2025-05-16T23:39:23Z","timestamp":1747438763000},"score":1,"resource":{"primary":{"URL":"http:\/\/jnm.snmjournals.org\/lookup\/doi\/10.2967\/jnumed.114.147488"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,1,15]]},"references-count":33,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2015,2,2]]},"published-print":{"date-parts":[[2015,2]]}},"alternative-id":["10.2967\/jnumed.114.147488"],"URL":"https:\/\/doi.org\/10.2967\/jnumed.114.147488","relation":{},"ISSN":["0161-5505","2159-662X"],"issn-type":[{"value":"0161-5505","type":"print"},{"value":"2159-662X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,1,15]]}}}