{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T04:13:36Z","timestamp":1790741616863,"version":"4.1.0"},"reference-count":27,"publisher":"Society of Nuclear Medicine","issue":"9","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Nucl Med"],"published-print":{"date-parts":[[2018,9]]},"DOI":"10.2967\/jnumed.118.207753","type":"journal-article","created":{"date-parts":[[2018,5,4]],"date-time":"2018-05-04T12:02:00Z","timestamp":1525435320000},"page":"1461-1466","source":"Crossref","is-referenced-by-count":21,"title":["Dual-Isotope Cryoimaging Quantitative Autoradiography: Investigating Antibody\u2013Drug Conjugate Distribution and Payload Delivery Through Imaging"],"prefix":"10.2967","volume":"59","author":[{"given":"Ohad","family":"Ilovich","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammed","family":"Qutaish","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jacob Y.","family":"Hesterman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kelly","family":"Orcutt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jack","family":"Hoppin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ildiko","family":"Polyak","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marc","family":"Seaman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adnan O.","family":"Abu-Yousif","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Donna","family":"Cvet","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel P.","family":"Bradley","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1602","published-online":{"date-parts":[[2018,5,4]]},"reference":[{"key":"2021051712122526000_59.9.1461.1","first-page":"113","article-title":"A therapeutic trial of maytansine","volume":"1","author":"Blum","year":"1978","journal-title":"Cancer Clin Trials."},{"key":"2021051712122526000_59.9.1461.2","doi-asserted-by":"publisher","DOI":"10.1007\/s002800050995"},{"key":"2021051712122526000_59.9.1461.3","doi-asserted-by":"publisher","DOI":"10.1021\/bc9002019"},{"key":"2021051712122526000_59.9.1461.4","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-62703-541-5_5"},{"key":"2021051712122526000_59.9.1461.5","doi-asserted-by":"publisher","DOI":"10.1016\/j.addr.2007.06.008"},{"key":"2021051712122526000_59.9.1461.6","doi-asserted-by":"crossref","first-page":"1421\u20131434","DOI":"10.1016\/j.addr.2008.04.012","article-title":"Antibody tumor penetration: transport opposed by systemic and antigen-mediated clearance","volume":"60","author":"Thurber","year":"2008","journal-title":"Adv Drug Deliv Rev."},{"key":"2021051712122526000_59.9.1461.7","doi-asserted-by":"publisher","DOI":"10.1002\/anie.201408103"},{"key":"2021051712122526000_59.9.1461.8","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2013-10-535088"},{"key":"2021051712122526000_59.9.1461.9","doi-asserted-by":"publisher","DOI":"10.1158\/1535-7163.MCT-13-0926"},{"key":"2021051712122526000_59.9.1461.10","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2014.57.8278"},{"key":"2021051712122526000_59.9.1461.11","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1016\/j.molonc.2010.09.002","article-title":"MALDI imaging mass spectrometry: painting molecular pictures","volume":"4","author":"Schwamborn","year":"2010","journal-title":"Mol Oncol."},{"key":"2021051712122526000_59.9.1461.12","doi-asserted-by":"crossref","first-page":"967","DOI":"10.1007\/s13361-015-1132-z","article-title":"Imaging MALDI MS of dosed brain tissues utilizing an alternative analyte pre-extraction approach","volume":"26","author":"Quiason","year":"2015","journal-title":"J Am Soc Mass Spectrom."},{"key":"2021051712122526000_59.9.1461.13","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1016\/j.pscychresns.2014.10.026","article-title":"[3H]Ifenprodil binding in post-mortem brains of Cloninger type 1 and 2 alcoholics: a whole-hemisphere autoradiography study","volume":"231","author":"Kupila","year":"2015","journal-title":"Psychiatry Res."},{"key":"2021051712122526000_59.9.1461.14","doi-asserted-by":"crossref","first-page":"157923","DOI":"10.1155\/2014\/157923","article-title":"Evaluation of inhibitory effect of recreational drugs on dopaminergic terminal neuron by PET and whole-body autoradiography","volume":"2014","author":"Yeh","year":"2014","journal-title":"Biomed Res Int."},{"key":"2021051712122526000_59.9.1461.15","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1016\/j.apradiso.2013.03.091","article-title":"Acute effects of three club drugs on the striatum of rats: evaluation by quantitative autoradiography with [18F]FDOPA","volume":"77","author":"Fang","year":"2013","journal-title":"Appl Radiat Isot."},{"key":"2021051712122526000_59.9.1461.16","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1007\/s00441-014-2093-4","article-title":"Autoradiography techniques and quantification of drug distribution","volume":"360","author":"Solon","year":"2015","journal-title":"Cell Tissue Res."},{"key":"2021051712122526000_59.9.1461.17","doi-asserted-by":"publisher","DOI":"10.1021\/tx200509f"},{"key":"2021051712122526000_59.9.1461.18","doi-asserted-by":"crossref","first-page":"610","DOI":"10.1117\/12.596953","article-title":"Color histogram specification by histogram warping","volume":"5667","author":"Grundland","year":"2005","journal-title":"Proc SPIE."},{"key":"2021051712122526000_59.9.1461.19","doi-asserted-by":"crossref","first-page":"656","DOI":"10.1007\/s11307-016-1041-y","article-title":"Molecular simulation of receptor occupancy and tumor penetration of an antibody and smaller scaffolds: application to molecular imaging","volume":"19","author":"Orcutt","year":"2017","journal-title":"Mol Imaging Biol."},{"key":"2021051712122526000_59.9.1461.20","doi-asserted-by":"publisher","DOI":"10.2967\/jnumed.114.140038"},{"key":"2021051712122526000_59.9.1461.21","doi-asserted-by":"publisher","DOI":"10.1002\/elps.1150110503"},{"key":"2021051712122526000_59.9.1461.22","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-15-1795"},{"key":"2021051712122526000_59.9.1461.23","doi-asserted-by":"crossref","first-page":"e44","DOI":"10.1016\/j.nucmedbio.2014.01.009","article-title":"Biodistribution of a 67Ga-labeled anti-TNF VHH single-domain antibody containing a bacterial albumin-binding domain (Zag)","volume":"41","author":"Morais","year":"2014","journal-title":"Nucl Med Biol."},{"key":"2021051712122526000_59.9.1461.24","first-page":"355","article-title":"Production and quality control of [67Ga]-DOTA-trastuzumab for radioimmunoscintigraphy","volume":"12","author":"Alirezapour","year":"2013","journal-title":"Iran J Pharm Res."},{"key":"2021051712122526000_59.9.1461.25","doi-asserted-by":"publisher","DOI":"10.1007\/s00259-010-1392-6"},{"key":"2021051712122526000_59.9.1461.26","unstructured":"Walter SE . Drug Localization in Tissues and Cells. Chapel Hill, NC: IDDC Press; 2003:26\u201327."},{"key":"2021051712122526000_59.9.1461.27","doi-asserted-by":"crossref","first-page":"1623","DOI":"10.1021\/acs.molpharmaceut.6b01091","article-title":"Tracking antibody distribution with near-infrared fluorescent dyes: impact of dye structure and degree of labeling on plasma clearance","volume":"14","author":"Cilliers","year":"2017","journal-title":"Mol Pharm."}],"container-title":["Journal of Nuclear Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.2967\/jnumed.118.207753","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,5,17]],"date-time":"2021-05-17T20:30:16Z","timestamp":1621283416000},"score":1,"resource":{"primary":{"URL":"http:\/\/jnm.snmjournals.org\/lookup\/doi\/10.2967\/jnumed.118.207753"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,5,4]]},"references-count":27,"journal-issue":{"issue":"9","published-online":{"date-parts":[[2018,9,4]]},"published-print":{"date-parts":[[2018,9]]}},"alternative-id":["10.2967\/jnumed.118.207753"],"URL":"https:\/\/doi.org\/10.2967\/jnumed.118.207753","relation":{},"ISSN":["0161-5505","2159-662X"],"issn-type":[{"value":"0161-5505","type":"print"},{"value":"2159-662X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,5,4]]}}}