{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,30]],"date-time":"2026-10-30T02:54:16Z","timestamp":1793328856157,"version":"4.5.0"},"reference-count":56,"publisher":"Society of Nuclear Medicine","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Nucl Med"],"accepted":{"date-parts":[[2020,10,21]]},"published-print":{"date-parts":[[2021,2]]},"DOI":"10.2967\/jnumed.120.244806","type":"journal-article","created":{"date-parts":[[2020,10,30]],"date-time":"2020-10-30T22:45:15Z","timestamp":1604097915000},"page":"160-167","source":"Crossref","is-referenced-by-count":252,"title":["The Latest Developments in Imaging of Fibroblast Activation Protein"],"prefix":"10.2967","volume":"62","author":[{"given":"Annette","family":"Altmann","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Uwe","family":"Haberkorn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jens","family":"Siveke","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1602","published-online":{"date-parts":[[2020,10,30]]},"reference":[{"key":"2025012107350624000_62.2.160.1","doi-asserted-by":"crossref","first-page":"3203","DOI":"10.3892\/mmr.2015.3197","article-title":"Fibroblast activation protein \u03b1 in tumor microenvironment: recent progression and implications","volume":"11","author":"Zi","year":"2015","journal-title":"Mol Med Rep."},{"key":"2025012107350624000_62.2.160.2","doi-asserted-by":"publisher","DOI":"10.1186\/s13058-016-0740-2"},{"key":"2025012107350624000_62.2.160.3","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-06-1746"},{"key":"2025012107350624000_62.2.160.4","doi-asserted-by":"publisher","DOI":"10.1097\/MPA.0b013e31816618ce"},{"key":"2025012107350624000_62.2.160.5","doi-asserted-by":"publisher","DOI":"10.1101\/gad.279737.116"},{"key":"2025012107350624000_62.2.160.6","doi-asserted-by":"publisher","DOI":"10.1038\/s41388-019-0765-y"},{"key":"2025012107350624000_62.2.160.7","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.91.12.5657"},{"key":"2025012107350624000_62.2.160.8","doi-asserted-by":"crossref","first-page":"e0116683","DOI":"10.1371\/journal.pone.0116683","article-title":"Fibroblast activation protein overexpression and clinical implications in solid tumors: a meta-analysis","volume":"10","author":"Liu","year":"2015","journal-title":"PLoS One."},{"key":"2025012107350624000_62.2.160.9","doi-asserted-by":"crossref","first-page":"1933","DOI":"10.2741\/4682","article-title":"Targeting fibroblast activation protein in cancer: prospects and caveats","volume":"23","author":"Busek","year":"2018","journal-title":"Front Biosci (Landmark Ed)."},{"key":"2025012107350624000_62.2.160.10","doi-asserted-by":"crossref","first-page":"4343","DOI":"10.1038\/s41388-018-0275-3","article-title":"Pro-tumorigenic roles of fibroblast activation protein in cancer: back to the basics","volume":"37","author":"Pur\u00e9","year":"2018","journal-title":"Oncogene."},{"key":"2025012107350624000_62.2.160.11","doi-asserted-by":"publisher","DOI":"10.1002\/prca.201300095"},{"key":"2025012107350624000_62.2.160.12","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/S0925-4439(97)00032-X","article-title":"Molecular cloning of seprase: a serine integral membrane protease from human melanoma","volume":"1361","author":"Goldstein","year":"1997","journal-title":"Biochim Biophys Acta."},{"key":"2025012107350624000_62.2.160.13","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-05-1245"},{"key":"2025012107350624000_62.2.160.14","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1016\/j.ejphar.2017.05.022","article-title":"Effects of the fibroblast activation protein inhibitor, PT100, in a murine model of pulmonary fibrosis","volume":"809","author":"Egger","year":"2017","journal-title":"Eur J Pharmacol."},{"key":"2025012107350624000_62.2.160.15","doi-asserted-by":"publisher","DOI":"10.1111\/jth.12396"},{"key":"2025012107350624000_62.2.160.16","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1016\/j.yjmcc.2015.08.016","article-title":"Fibroblast activation protein alpha expression identifies activated fibroblasts after myocardial infarction","volume":"87","author":"Tillmanns","year":"2015","journal-title":"J Mol Cell Cardiol."},{"key":"2025012107350624000_62.2.160.17","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-017-09790-1"},{"key":"2025012107350624000_62.2.160.18","doi-asserted-by":"crossref","first-page":"1220","DOI":"10.2174\/156652412803833607","article-title":"Fibroblast activation protein in remodeling tissues","volume":"12","author":"Jacob","year":"2012","journal-title":"Curr Mol Med."},{"key":"2025012107350624000_62.2.160.19","doi-asserted-by":"publisher","DOI":"10.4161\/cbt.6.11.4874"},{"key":"2025012107350624000_62.2.160.20","doi-asserted-by":"publisher","DOI":"10.1016\/j.clon.2009.04.007"},{"key":"2025012107350624000_62.2.160.21","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2407-9-263"},{"key":"2025012107350624000_62.2.160.22","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1021\/ml300410d","article-title":"Selective inhibitors of fibroblast activation protein (FAP) with a (4-quinolinoyl)-glycyl-2-cyanopyrrolidine scaffold","volume":"4","author":"Jansen","year":"2013","journal-title":"ACS Med Chem Lett."},{"key":"2025012107350624000_62.2.160.23","doi-asserted-by":"publisher","DOI":"10.1021\/jm500031w"},{"key":"2025012107350624000_62.2.160.24","doi-asserted-by":"publisher","DOI":"10.1158\/1535-7163.MCT-11-0340"},{"key":"2025012107350624000_62.2.160.25","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1016\/j.ejmech.2016.12.056","article-title":"A tumor-targeted activatable phthalocyanine-tetrapeptide-doxorubicin conjugate for synergistic chemo-photodynamic therapy","volume":"127","author":"Ke","year":"2017","journal-title":"Eur J Med Chem."},{"key":"2025012107350624000_62.2.160.26","doi-asserted-by":"publisher","DOI":"10.1373\/clinchem.2012.185363"},{"key":"2025012107350624000_62.2.160.27","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-07-5211"},{"key":"2025012107350624000_62.2.160.28","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-14-3041"},{"key":"2025012107350624000_62.2.160.29","doi-asserted-by":"publisher","DOI":"10.1172\/JCI26532"},{"key":"2025012107350624000_62.2.160.30","unstructured":"Zimmermann C, Babich JW, Joyal J, Marquis J, Wang J-C, inventors; Molecular Insight Pharmaceuticals, Inc., assignee. Selective seprase inhibitors. US patent 2010\/0098633 A1. April 22, 2010."},{"key":"2025012107350624000_62.2.160.31","doi-asserted-by":"publisher","DOI":"10.2967\/jnumed.118.210435"},{"key":"2025012107350624000_62.2.160.32","doi-asserted-by":"publisher","DOI":"10.2967\/jnumed.118.224469"},{"key":"2025012107350624000_62.2.160.33","doi-asserted-by":"publisher","DOI":"10.2967\/jnumed.118.210443"},{"key":"2025012107350624000_62.2.160.34","doi-asserted-by":"publisher","DOI":"10.2967\/jnumed.118.215913"},{"key":"2025012107350624000_62.2.160.35","doi-asserted-by":"publisher","DOI":"10.2967\/jnumed.119.227967"},{"key":"2025012107350624000_62.2.160.36","doi-asserted-by":"publisher","DOI":"10.2967\/jnumed.119.236786"},{"key":"2025012107350624000_62.2.160.37","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1186\/s41181-020-00102-z","article-title":"Targeting fibroblast activation protein (FAP): next generation PET radiotracers using squaramide coupled bifunctional DOTA and DATA(5m) chelators","volume":"5","author":"Moon","year":"2020","journal-title":"EJNMMI Radiopharm Chem."},{"key":"2025012107350624000_62.2.160.38","doi-asserted-by":"crossref","unstructured":"Toms J Kogler J Maschauer S . Targeting fibroblast activation protein: radiosynthesis and preclinical evaluation of an 18F-labeled FAP inhibitor. J Nucl Med. April 24, 2020 [Epub ahead of print].","DOI":"10.2967\/jnumed.120.242958"},{"key":"2025012107350624000_62.2.160.39","doi-asserted-by":"crossref","unstructured":"Giesel F Adeberg S Syed M . FAPI-74 PET\/CT using either 18F-AlF or cold-kit 68Ga-labeling: biodistribution, radiation dosimetry and tumor delineation in lung cancer patients . J Nucl Med. June 26, 2020 [Epub ahead of print].","DOI":"10.2967\/jnumed.120.245084"},{"key":"2025012107350624000_62.2.160.40","doi-asserted-by":"crossref","unstructured":"Lindner T Altmann A Kraemer S . Design and development of 99mTc labeled FAPI-tracers for SPECT-imaging and 188Re therapy . J Nucl Med. March 13, 2020 [Epub ahead of print].","DOI":"10.2967\/jnumed.119.239731"},{"key":"2025012107350624000_62.2.160.41","doi-asserted-by":"crossref","first-page":"1820","DOI":"10.1007\/s00259-020-04769-z","article-title":"Comparison of (68Ga)Ga-DOTA-FAPI-04 and (18F)FDG PET\/CT for the diagnosis of primary and metastatic lesions in patients with various types of cancer","volume":"47","author":"Chen","year":"2020","journal-title":"Eur J Nucl Med Mol Imaging."},{"key":"2025012107350624000_62.2.160.42","doi-asserted-by":"crossref","unstructured":"Chen H Zhao L Ruan D . Usefulness of [68Ga]Ga-DOTA-FAPI-04 PET\/CT in patients presenting with inconclusive [18F]FDG PET\/CT findings. Eur J Nucl Med Mol Imaging. June 25, 2020 [Epub ahead of print].","DOI":"10.1007\/s00259-020-04940-6"},{"key":"2025012107350624000_62.2.160.43","doi-asserted-by":"crossref","unstructured":"Shi X Xing H Yang X . Fibroblast imaging of hepatic carcinoma with 68Ga-FAPI-04 PET\/CT: a pilot study in patients with suspected hepatic nodules. Eur J Nucl Med Mol Imaging. May 29, 2020 [Epub ahead of print].","DOI":"10.1007\/s00259-020-04882-z"},{"key":"2025012107350624000_62.2.160.44","doi-asserted-by":"crossref","first-page":"2569","DOI":"10.1007\/s00259-019-04444-y","article-title":"IDH-wildtype glioblastomas and grade III\/IV IDH-mutant gliomas show elevated tracer uptake in fibroblast activation protein-specific PET\/CT","volume":"46","author":"R\u00f6hrich","year":"2019","journal-title":"Eur J Nucl Med Mol Imaging."},{"key":"2025012107350624000_62.2.160.45","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1016\/j.radonc.2020.06.040","article-title":"Fibroblast activation protein (FAP) specific PET for advanced target volume delineation in glioblastoma","volume":"150","author":"Windisch","year":"2020","journal-title":"Radiother Oncol."},{"key":"2025012107350624000_62.2.160.46","doi-asserted-by":"crossref","first-page":"2836","DOI":"10.1007\/s00259-020-04859-y","article-title":"Fibroblast activation protein inhibitor (FAPI) PET for diagnostics and advanced targeted radiotherapy in head and neck cancers","volume":"47","author":"Syed","year":"2020","journal-title":"Eur J Nucl Med Mol Imaging."},{"key":"2025012107350624000_62.2.160.47","unstructured":"Koerber SA Staudinger F Kratochwil C . The role of FAPI-PET\/CT for patients with malignancies of the lower gastrointestinal tract: first clinical experience. J Nucl Med. February 14, 2020 [Epub ahead of print]."},{"key":"2025012107350624000_62.2.160.48","doi-asserted-by":"publisher","DOI":"10.2967\/jnumed.114.152959"},{"key":"2025012107350624000_62.2.160.49","doi-asserted-by":"publisher","DOI":"10.2967\/jnumed.115.162628"},{"key":"2025012107350624000_62.2.160.50","doi-asserted-by":"publisher","DOI":"10.2967\/jnumed.116.177931"},{"key":"2025012107350624000_62.2.160.51","doi-asserted-by":"crossref","unstructured":"Luo Y Pan Q Yang H . Fibroblast activation protein targeted PET\/CT with 68Ga-FAPI for imaging IgG4-related disease: comparison to 18F-FDG PET\/CT. J Nucl Med. June 8, 2020 [Epub ahead of print].","DOI":"10.2967\/jnumed.120.244723"},{"key":"2025012107350624000_62.2.160.52","doi-asserted-by":"crossref","unstructured":"Schmidkonz C Rauber S Atzinger A . Disentangling inflammatory from fibrotic disease activity by fibroblast activation protein imaging. Ann Rheum Dis. July 21, 2020 [Epub ahead of print].","DOI":"10.1055\/s-0041-1726701"},{"key":"2025012107350624000_62.2.160.53","doi-asserted-by":"publisher","DOI":"10.2967\/jnumed.119.226993"},{"key":"2025012107350624000_62.2.160.54","doi-asserted-by":"crossref","first-page":"1060","DOI":"10.1093\/eurheartj\/ehz736","article-title":"Cardiac fibroblast activation detected by positron emission tomography\/computed tomography as a possible sign of cardiotoxicity","volume":"41","author":"Totzeck","year":"2020","journal-title":"Eur Heart J."},{"key":"2025012107350624000_62.2.160.55","doi-asserted-by":"publisher","DOI":"10.2967\/jnumed.119.233122"},{"key":"2025012107350624000_62.2.160.56","doi-asserted-by":"publisher","DOI":"10.1038\/nrc.2016.73"}],"container-title":["Journal of Nuclear Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.2967\/jnumed.120.244806","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,1,21]],"date-time":"2025-01-21T11:07:19Z","timestamp":1737457639000},"score":1,"resource":{"primary":{"URL":"http:\/\/jnm.snmjournals.org\/lookup\/doi\/10.2967\/jnumed.120.244806"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,10,30]]},"references-count":56,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2021,1,19]]},"published-print":{"date-parts":[[2021,2]]}},"alternative-id":["10.2967\/jnumed.120.244806"],"URL":"https:\/\/doi.org\/10.2967\/jnumed.120.244806","relation":{},"ISSN":["0161-5505","2159-662X"],"issn-type":[{"value":"0161-5505","type":"print"},{"value":"2159-662X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,10,30]]}}}