{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T05:44:04Z","timestamp":1790401444311,"version":"4.1.0"},"reference-count":53,"publisher":"Society of Nuclear Medicine","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Nucl Med"],"published-print":{"date-parts":[[2022,1]]},"DOI":"10.2967\/jnumed.120.254961","type":"journal-article","created":{"date-parts":[[2021,4,16]],"date-time":"2021-04-16T14:18:23Z","timestamp":1618582703000},"page":"108-116","source":"Crossref","is-referenced-by-count":97,"title":["Direct Comparison of the Tau PET Tracers<sup>18<\/sup>F-Flortaucipir and<sup>18<\/sup>F-MK-6240 in Human Subjects"],"prefix":"10.2967","volume":"63","author":[{"given":"Alexandra","family":"Gogola","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Davneet S.","family":"Minhas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Victor L.","family":"Villemagne","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ann D.","family":"Cohen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James M.","family":"Mountz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tharick A.","family":"Pascoal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charles M.","family":"Laymon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N. Scott","family":"Mason","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Milos D.","family":"Ikonomovic","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chester A.","family":"Mathis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Beth E.","family":"Snitz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Oscar L.","family":"Lopez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William E.","family":"Klunk","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brian J.","family":"Lopresti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1602","published-online":{"date-parts":[[2021,4,16]]},"reference":[{"key":"2022032309401373000_63.1.108.1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1566067"},{"key":"2022032309401373000_63.1.108.2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2016.01.028"},{"key":"2022032309401373000_63.1.108.3","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/aww027"},{"key":"2022032309401373000_63.1.108.4","doi-asserted-by":"publisher","DOI":"10.1038\/s41380-018-0342-8"},{"key":"2022032309401373000_63.1.108.5","doi-asserted-by":"publisher","DOI":"10.1186\/s13024-017-0162-3"},{"key":"2022032309401373000_63.1.108.6","doi-asserted-by":"publisher","DOI":"10.1002\/ana.24546"},{"key":"2022032309401373000_63.1.108.7","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1053\/j.semnuclmed.2016.09.006","article-title":"A\u03b2-amyloid and tau imaging in dementia","volume":"47","author":"Villemagne","year":"2017","journal-title":"Semin Nucl Med."},{"key":"2022032309401373000_63.1.108.8","doi-asserted-by":"publisher","DOI":"10.3233\/JAD-122059"},{"key":"2022032309401373000_63.1.108.9","doi-asserted-by":"crossref","first-page":"4778","DOI":"10.1021\/acs.jmedchem.6b00166","article-title":"Discovery of 6-(fluoro-18F)-3-(1H-pyrrolo[2,3-C]pyridin-1-yl)isoquinolin-5-amine (18F-MK-6240): a positron emission tomography (PET) imaging agent for quantification of neurofibrillary tangles (NFTs)","volume":"59","author":"Walji","year":"2016","journal-title":"J Med Chem."},{"key":"2022032309401373000_63.1.108.10","doi-asserted-by":"crossref","first-page":"829","DOI":"10.1001\/jamaneurol.2020.0528","article-title":"Positron emission tomography imaging with 18F-flortaucipir and postmortem assessment of Alzheimer disease neuropathologic changes","volume":"77","author":"Fleisher","year":"2020","journal-title":"JAMA Neurol."},{"key":"2022032309401373000_63.1.108.11","doi-asserted-by":"publisher","DOI":"10.1016\/0197-4580(95)00021-6"},{"key":"2022032309401373000_63.1.108.12","doi-asserted-by":"crossref","first-page":"1151","DOI":"10.1001\/jama.2018.12917","article-title":"Discriminative accuracy of 18F-flortaucipir positron emission tomography for Alzheimer disease vs other neurodegenerative disorders","volume":"320","author":"Ossenkoppele","year":"2018","journal-title":"JAMA."},{"key":"2022032309401373000_63.1.108.13","doi-asserted-by":"publisher","DOI":"10.2967\/jnumed.115.170027"},{"key":"2022032309401373000_63.1.108.14","doi-asserted-by":"publisher","DOI":"10.2967\/jnumed.117.200691"},{"key":"2022032309401373000_63.1.108.15","doi-asserted-by":"crossref","first-page":"486","DOI":"10.3389\/fneur.2019.00486","article-title":"Alzheimer\u2019s Disease Neuroimaging Initiative. Quantitative 18F-AV1451 brain tau PET imaging in cognitively normal older adults, mild cognitive impairment, and Alzheimer\u2019s disease patients","volume":"10","author":"Zhao","year":"2019","journal-title":"Front Neurol."},{"key":"2022032309401373000_63.1.108.16","doi-asserted-by":"publisher","DOI":"10.2967\/jnumed.118.224113"},{"key":"2022032309401373000_63.1.108.17","doi-asserted-by":"publisher","DOI":"10.2967\/jnumed.115.171678"},{"key":"2022032309401373000_63.1.108.18","doi-asserted-by":"publisher","DOI":"10.2967\/jnumed.118.208215"},{"key":"2022032309401373000_63.1.108.19","doi-asserted-by":"publisher","DOI":"10.1186\/s13195-018-0402-y"},{"key":"2022032309401373000_63.1.108.20","doi-asserted-by":"crossref","first-page":"2099","DOI":"10.1007\/s00259-019-04419-z","article-title":"Evaluation of pharmacokinetic modeling strategies for in-vivo quantification of tau with the radiotracer 18F-MK-6240 in human subjects","volume":"46","author":"Guehl","year":"2019","journal-title":"Eur J Nucl Med Mol Imaging."},{"key":"2022032309401373000_63.1.108.21","doi-asserted-by":"publisher","DOI":"10.2967\/jnumed.118.209650"},{"key":"2022032309401373000_63.1.108.22","doi-asserted-by":"crossref","first-page":"2179","DOI":"10.1177\/0271678X19887781","article-title":"Test-retest characteristic of 18F-MK-6240 quantitative outcomes in cognitively normal adults and subjects with Alzheimer\u2019s disease","volume":"40","author":"Salinas","year":"2020","journal-title":"J Cereb Blood Flow Metab."},{"key":"2022032309401373000_63.1.108.23","doi-asserted-by":"crossref","first-page":"2818","DOI":"10.1093\/brain\/awaa180","article-title":"18F-MK-6240 PET for early and late detection of neurofibrillary tangles","volume":"143","author":"Pascoal","year":"2020","journal-title":"Brain."},{"key":"2022032309401373000_63.1.108.24","doi-asserted-by":"publisher","DOI":"10.1016\/j.jalz.2011.03.004"},{"key":"2022032309401373000_63.1.108.25","doi-asserted-by":"crossref","first-page":"831","DOI":"10.3389\/fneur.2019.00831","article-title":"18F-FDG, 11C-PIB, and 18F-AV-1451 PET imaging of neurodegeneration in two subjects with a history of repetitive trauma and cognitive decline","volume":"10","author":"Okonkwo","year":"2019","journal-title":"Front Neurol."},{"key":"2022032309401373000_63.1.108.26","doi-asserted-by":"publisher","DOI":"10.2967\/jnumed.108.057612"},{"key":"2022032309401373000_63.1.108.27","doi-asserted-by":"publisher","DOI":"10.1093\/cercor\/bhg087"},{"key":"2022032309401373000_63.1.108.28","doi-asserted-by":"publisher","DOI":"10.2967\/jnumed.116.175273"},{"key":"2022032309401373000_63.1.108.29","doi-asserted-by":"publisher","DOI":"10.1002\/ana.24517"},{"key":"2022032309401373000_63.1.108.30","first-page":"206","article-title":"Hyperostosis frontalis interna: case report and review of literature","volume":"34","author":"She","year":"2004","journal-title":"Ann Clin Lab Sci."},{"key":"2022032309401373000_63.1.108.31","doi-asserted-by":"publisher","DOI":"10.1002\/ajhb.21156"},{"key":"2022032309401373000_63.1.108.32","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1096-8644(199907)109:3<303::AID-AJPA3>3.0.CO;2-I"},{"key":"2022032309401373000_63.1.108.33","doi-asserted-by":"publisher","DOI":"10.1007\/s00259-014-2753-3"},{"key":"2022032309401373000_63.1.108.34","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp-2012-302548"},{"key":"2022032309401373000_63.1.108.35","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4939-7704-8_13"},{"key":"2022032309401373000_63.1.108.36","doi-asserted-by":"publisher","DOI":"10.1007\/s00259-012-2088-x"},{"key":"2022032309401373000_63.1.108.37","doi-asserted-by":"publisher","DOI":"10.2967\/jnumed.118.210518"},{"key":"2022032309401373000_63.1.108.38","doi-asserted-by":"publisher","DOI":"10.1016\/j.jalz.2014.07.003"},{"key":"2022032309401373000_63.1.108.39","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.2990-05.2005"},{"key":"2022032309401373000_63.1.108.40","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.23-06-02086.2003"},{"key":"2022032309401373000_63.1.108.41","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1186\/s40478-016-0315-6","article-title":"An autoradiographic evaluation of AV-1451 tau PET in dementia","volume":"4","author":"Lowe","year":"2016","journal-title":"Acta Neuropathol Commun."},{"key":"2022032309401373000_63.1.108.42","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbadis.2004.09.008"},{"key":"2022032309401373000_63.1.108.43","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1016\/j.neulet.2019.04.022","article-title":"The complexity of tau in Alzheimer\u2019s disease","volume":"705","author":"Naseri","year":"2019","journal-title":"Neurosci Lett."},{"key":"2022032309401373000_63.1.108.44","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1186\/s40478-019-0686-6","article-title":"Autoradiography validation of novel tau PET tracer 18F-MK-6240 on human postmortem brain tissue","volume":"7","author":"Aguero","year":"2019","journal-title":"Acta Neuropathol Commun."},{"key":"2022032309401373000_63.1.108.45","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1002\/ana.24844","article-title":"Pathological correlations of 18F-AV-1451 imaging in non-Alzheimer tauopathies","volume":"81","author":"Marqui\u00e9","year":"2017","journal-title":"Ann Neurol."},{"key":"2022032309401373000_63.1.108.46","doi-asserted-by":"crossref","first-page":"596","DOI":"10.1021\/acschemneuro.0c00801","article-title":"Radiosynthesis, in\u00a0vitro and in\u00a0vivo evaluation of 18F-CBD-2115 as a first-in-class radiotracer for imaging 4R-tauopathies","volume":"12","author":"Lindberg","year":"2021","journal-title":"ACS Chem Neurosci."},{"key":"2022032309401373000_63.1.108.47","first-page":"781","article-title":"18F-AV-1451 positron emission tomography in Alzheimer\u2019s disease and progressive supranuclear palsy","volume":"140","author":"Passamonti","year":"2017","journal-title":"Brain."},{"key":"2022032309401373000_63.1.108.48","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/j.parkreldis.2017.12.016","article-title":"Pittsburgh compound B and AV-1451 positron emission tomography assessment of molecular pathologies of Alzheimer\u2019s disease in progressive supranuclear palsy","volume":"48","author":"Whitwell","year":"2018","journal-title":"Parkinsonism Relat Disord."},{"key":"2022032309401373000_63.1.108.49","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1002\/mds.26813","article-title":"Increased basal ganglia binding of 18F-AV-1451 in patients with progressive supranuclear palsy","volume":"32","author":"Smith","year":"2017","journal-title":"Mov Disord."},{"key":"2022032309401373000_63.1.108.50","doi-asserted-by":"publisher","DOI":"10.1007\/s00401-017-1681-2"},{"key":"2022032309401373000_63.1.108.51","doi-asserted-by":"publisher","DOI":"10.1007\/s00401-014-1349-0"},{"key":"2022032309401373000_63.1.108.52","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awy059"},{"key":"2022032309401373000_63.1.108.53","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3941\/jrcr.v13i8.3633","article-title":"Intracranial calcifications on CT: an updated review","volume":"13","author":"Saade","year":"2019","journal-title":"J Radiol Case Rep."}],"container-title":["Journal of Nuclear Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.2967\/jnumed.120.254961","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,2]],"date-time":"2023-11-02T06:20:39Z","timestamp":1698906039000},"score":1,"resource":{"primary":{"URL":"http:\/\/jnm.snmjournals.org\/lookup\/doi\/10.2967\/jnumed.120.254961"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,4,16]]},"references-count":53,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2022,1,3]]},"published-print":{"date-parts":[[2022,1]]}},"alternative-id":["10.2967\/jnumed.120.254961"],"URL":"https:\/\/doi.org\/10.2967\/jnumed.120.254961","relation":{},"ISSN":["0161-5505","2159-662X"],"issn-type":[{"value":"0161-5505","type":"print"},{"value":"2159-662X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,4,16]]}}}