{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T00:08:47Z","timestamp":1780445327679,"version":"3.54.1"},"reference-count":42,"publisher":"Society of Nuclear Medicine","issue":"10","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Nucl Med"],"published-print":{"date-parts":[[2022,10]]},"DOI":"10.2967\/jnumed.121.263039","type":"journal-article","created":{"date-parts":[[2022,2,17]],"date-time":"2022-02-17T21:10:21Z","timestamp":1645132221000},"page":"1570-1578","source":"Crossref","is-referenced-by-count":24,"title":["Tracking Innate Immune Activation in a Mouse Model of Parkinson\u2019s Disease Using TREM1 and TSPO PET Tracers"],"prefix":"10.2967","volume":"63","author":[{"given":"Katherine L.","family":"Lucot","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marc Y.","family":"Stevens","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T. Adam","family":"Bonham","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E. Carmen","family":"Azevedo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aisling M.","family":"Chaney","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ebony D.","family":"Webber","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Poorva","family":"Jain","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jessica L.","family":"Klockow","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isaac M.","family":"Jackson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mackenzie L.","family":"Carlson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edward E.","family":"Graves","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas J.","family":"Montine","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michelle L.","family":"James","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1602","published-online":{"date-parts":[[2022,2,17]]},"reference":[{"key":"2022100315301342000_63.10.1570.1","doi-asserted-by":"publisher","DOI":"10.1007\/s00401-014-1343-6"},{"key":"2022100315301342000_63.10.1570.2","doi-asserted-by":"publisher","DOI":"10.1111\/jnc.13517"},{"key":"2022100315301342000_63.10.1570.3","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.neuro.28.061604.135718"},{"key":"2022100315301342000_63.10.1570.4","doi-asserted-by":"publisher","DOI":"10.1002\/ana.25557"},{"key":"2022100315301342000_63.10.1570.5","doi-asserted-by":"publisher","DOI":"10.1038\/s41582-020-0344-4"},{"key":"2022100315301342000_63.10.1570.6","doi-asserted-by":"publisher","DOI":"10.1016\/j.nbd.2020.105028"},{"key":"2022100315301342000_63.10.1570.7","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.38.8.1285"},{"key":"2022100315301342000_63.10.1570.8","doi-asserted-by":"publisher","DOI":"10.1289\/ehp.6361"},{"key":"2022100315301342000_63.10.1570.9","doi-asserted-by":"publisher","DOI":"10.1016\/0304-3940(94)90746-3"},{"key":"2022100315301342000_63.10.1570.10","doi-asserted-by":"publisher","DOI":"10.1016\/0304-3940(94)90508-8"},{"key":"2022100315301342000_63.10.1570.11","doi-asserted-by":"publisher","DOI":"10.1016\/0304-3940(94)90684-X"},{"key":"2022100315301342000_63.10.1570.12","doi-asserted-by":"publisher","DOI":"10.1016\/j.neulet.2006.12.003"},{"key":"2022100315301342000_63.10.1570.13","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(09)70062-6"},{"key":"2022100315301342000_63.10.1570.14","doi-asserted-by":"publisher","DOI":"10.1016\/j.expneurol.2007.07.004"},{"key":"2022100315301342000_63.10.1570.15","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410240415"},{"key":"2022100315301342000_63.10.1570.16","doi-asserted-by":"publisher","DOI":"10.2967\/jnumed.115.167858"},{"key":"2022100315301342000_63.10.1570.17","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.0996-15.2015"},{"key":"2022100315301342000_63.10.1570.18","doi-asserted-by":"publisher","DOI":"10.2967\/jnumed.118.209155"},{"key":"2022100315301342000_63.10.1570.19","doi-asserted-by":"crossref","first-page":"1422","DOI":"10.7150\/thno.17666","article-title":"[18F]GE-180 PET detects reduced microglia activation after LM11A-31 therapy in a mouse model of Alzheimer\u2019s disease","volume":"7","author":"James","year":"2017","journal-title":"Theranostics."},{"key":"2022100315301342000_63.10.1570.20","doi-asserted-by":"publisher","DOI":"10.1007\/s00259-014-2939-8"},{"key":"2022100315301342000_63.10.1570.21","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1007\/s11307-016-0984-3","article-title":"Comparative evaluation of three TSPO PET radiotracers in a LPS-induced model of mild neuroinflammation in rats","volume":"19","author":"Sridharan","year":"2017","journal-title":"Mol Imaging Biol."},{"key":"2022100315301342000_63.10.1570.22","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmcl.2011.12.084"},{"key":"2022100315301342000_63.10.1570.23","doi-asserted-by":"publisher","DOI":"10.3390\/ijms20133161"},{"key":"2022100315301342000_63.10.1570.24","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.164.10.4991"},{"key":"2022100315301342000_63.10.1570.25","doi-asserted-by":"publisher","DOI":"10.1038\/s41590-019-0421-2"},{"key":"2022100315301342000_63.10.1570.26","first-page":"1506b","article-title":"Imaging the invaders: TREM1 as a novel PET imaging biomarker of peripheral infiltrating myeloid cells and potential therapeutic target in multiple sclerosis [abstract]","volume":"60","author":"Chaney","year":"2019","journal-title":"J Nucl Med."},{"key":"2022100315301342000_63.10.1570.27","first-page":"199","article-title":"TREM1-PET imaging of pro-inflammatory myeloid cells distinguishes active disease from remission in multiple sclerosis [abstract]","volume":"61","author":"Chaney","year":"2020","journal-title":"J Nucl Med."},{"key":"2022100315301342000_63.10.1570.28","doi-asserted-by":"publisher","DOI":"10.1602\/neurorx.2.3.484"},{"key":"2022100315301342000_63.10.1570.29","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1003900"},{"key":"2022100315301342000_63.10.1570.30","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1016\/j.bbr.2018.02.014","article-title":"Graded 6-OHDA-induced dopamine depletion in the nigrostriatal pathway evokes progressive pathological neuronal activities in the subthalamic nucleus of a hemi-parkinsonian mouse","volume":"344","author":"Park","year":"2018","journal-title":"Behav Brain Res."},{"key":"2022100315301342000_63.10.1570.31","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbr.2015.01.053"},{"key":"2022100315301342000_63.10.1570.32","first-page":"1271","article-title":"89Zr immuno-PET: comprehensive procedures for the production of 89Zr-labeled monoclonal antibodies","volume":"44","author":"Verel","year":"2003","journal-title":"J Nucl Med."},{"key":"2022100315301342000_63.10.1570.33","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(19)31817-3"},{"key":"2022100315301342000_63.10.1570.34","doi-asserted-by":"publisher","DOI":"10.1007\/s13311-017-0566-3"},{"key":"2022100315301342000_63.10.1570.35","first-page":"57243","article-title":"PET imaging of neuroinflammation using [11C]DPA-713 in a mouse model of ischemic stroke","volume":"136","author":"Chaney","year":"2018","journal-title":"J Vis Exp."},{"key":"2022100315301342000_63.10.1570.36","doi-asserted-by":"publisher","DOI":"10.1097\/j.pain.0000000000001607"},{"key":"2022100315301342000_63.10.1570.37","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.3558-14.2015"},{"key":"2022100315301342000_63.10.1570.38","doi-asserted-by":"publisher","DOI":"10.1046\/j.1460-9568.2002.01938.x"},{"key":"2022100315301342000_63.10.1570.39","doi-asserted-by":"publisher","DOI":"10.1210\/en.2015-1795"},{"key":"2022100315301342000_63.10.1570.40","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1002\/jnr.24185","article-title":"Updates on immunity and inflammation in Parkinson disease pathology","volume":"96","author":"Joshi","year":"2018","journal-title":"J Neurosci Res."},{"key":"2022100315301342000_63.10.1570.41","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.1860-14.2014"},{"key":"2022100315301342000_63.10.1570.42","doi-asserted-by":"publisher","DOI":"10.2967\/jnumed.109.062265"}],"container-title":["Journal of Nuclear Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.2967\/jnumed.121.263039","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,10,3]],"date-time":"2022-10-03T22:35:18Z","timestamp":1664836518000},"score":1,"resource":{"primary":{"URL":"http:\/\/jnm.snmjournals.org\/lookup\/doi\/10.2967\/jnumed.121.263039"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,2,17]]},"references-count":42,"journal-issue":{"issue":"10","published-online":{"date-parts":[[2022,10,3]]},"published-print":{"date-parts":[[2022,10]]}},"alternative-id":["10.2967\/jnumed.121.263039"],"URL":"https:\/\/doi.org\/10.2967\/jnumed.121.263039","relation":{},"ISSN":["0161-5505","2159-662X"],"issn-type":[{"value":"0161-5505","type":"print"},{"value":"2159-662X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,2,17]]}}}