{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,12]],"date-time":"2026-09-12T04:53:23Z","timestamp":1789188803351,"version":"build-2803163510"},"reference-count":40,"publisher":"Society of Nuclear Medicine","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Nucl Med"],"accepted":{"date-parts":[[2024,11,19]]},"published-print":{"date-parts":[[2025,1]]},"DOI":"10.2967\/jnumed.124.267657","type":"journal-article","created":{"date-parts":[[2025,1,3]],"date-time":"2025-01-03T21:15:26Z","timestamp":1735938926000},"page":"14-19","source":"Crossref","is-referenced-by-count":7,"title":["Molecular Imaging of Cancer Stem Cells and Their Role in Therapy Resistance"],"prefix":"10.2967","volume":"66","author":[{"given":"Sofia N.","family":"dos Santos","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Timothy H.","family":"Witney","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1602","published-online":{"date-parts":[[2025,1,3]]},"reference":[{"key":"2025010313152036000_66.1.14.1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21763"},{"key":"2025010313152036000_66.1.14.2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2020.10.027"},{"key":"2025010313152036000_66.1.14.3","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2020.01280"},{"key":"2025010313152036000_66.1.14.4","doi-asserted-by":"publisher","DOI":"10.1038\/nm0797-730"},{"key":"2025010313152036000_66.1.14.5","doi-asserted-by":"publisher","DOI":"10.1016\/j.stem.2018.11.011"},{"key":"2025010313152036000_66.1.14.6","doi-asserted-by":"crossref","unstructured":"Duan X Hu H Wang L Chen L . Aldehyde dehydrogenase 1 family: a potential molecule target for diseases. Cell Biol Int. 2024","DOI":"10.1002\/cbin.12188"},{"key":"2025010313152036000_66.1.14.7","doi-asserted-by":"crossref","first-page":"762","DOI":"10.1038\/s41568-023-00612-3","article-title":"Advances in the structure, mechanism and targeting of chemoresistance-linked ABC transporters","volume":"23","author":"Sajid","year":"2023","journal-title":"Nat Rev Cancer."},{"key":"2025010313152036000_66.1.14.8","doi-asserted-by":"crossref","first-page":"1897","DOI":"10.3390\/cancers15061897","article-title":"DNA repair and therapeutic strategies in cancer stem cells","volume":"15","author":"Gillespie","year":"2023","journal-title":"Cancers (Basel)."},{"key":"2025010313152036000_66.1.14.9","doi-asserted-by":"crossref","first-page":"13","DOI":"10.3390\/cancers13020328","article-title":"The great escape: the power of cancer stem cells to evade programmed cell death","volume":"13","author":"Castelli","year":"2021","journal-title":"Cancers (Basel)."},{"key":"2025010313152036000_66.1.14.10","doi-asserted-by":"crossref","first-page":"775","DOI":"10.1016\/j.trecan.2020.03.011","article-title":"Emerging mechanisms by which EMT programs control stemness","volume":"6","author":"Wilson","year":"2020","journal-title":"Trends Cancer."},{"key":"2025010313152036000_66.1.14.11","doi-asserted-by":"publisher","DOI":"10.1038\/s41568-023-00642-x"},{"key":"2025010313152036000_66.1.14.12","doi-asserted-by":"crossref","first-page":"167164","DOI":"10.1016\/j.bbadis.2024.167164","article-title":"Metabolic adaptations in cancer stem cells: a key to therapy resistance","volume":"1870","author":"Masoudi","year":"2024","journal-title":"Biochim Biophys Acta Mol Basis Dis."},{"key":"2025010313152036000_66.1.14.13","doi-asserted-by":"crossref","first-page":"624","DOI":"10.1016\/j.trecan.2020.12.014","article-title":"The role of the microenvironment and immune system in regulating stem cell fate in cancer","volume":"7","author":"Ferguson","year":"2021","journal-title":"Trends Cancer."},{"key":"2025010313152036000_66.1.14.14","doi-asserted-by":"crossref","first-page":"1227884","DOI":"10.3389\/fonc.2023.1227884","article-title":"Hypoxia-induced cancer cell reprogramming: a review on how cancer stem cells arise","volume":"13","author":"Abd","year":"2023","journal-title":"Front Oncol."},{"key":"2025010313152036000_66.1.14.15","doi-asserted-by":"publisher","DOI":"10.1038\/nrc2499"},{"key":"2025010313152036000_66.1.14.16","doi-asserted-by":"crossref","first-page":"4906934","DOI":"10.1155\/2022\/4906934","article-title":"Celecoxib-induced modulation of colon cancer CD133 expression occurs through AKT inhibition and is monitored by 89Zr immuno-PET","volume":"2022","author":"Jung","year":"2022","journal-title":"Mol Imaging."},{"key":"2025010313152036000_66.1.14.17","doi-asserted-by":"publisher","DOI":"10.2967\/jnumed.121.263511"},{"key":"2025010313152036000_66.1.14.18","doi-asserted-by":"crossref","first-page":"1402","DOI":"10.1021\/acs.molpharmaceut.3c01063","article-title":"Evaluating CD133 as a radiotheranostic target in small-cell lung cancer","volume":"21","author":"Sarrett","year":"2024","journal-title":"Mol Pharm."},{"key":"2025010313152036000_66.1.14.19","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1186\/s13550-024-01091-9","article-title":"Zr-labeled immunoPET targeting the cancer stem cell antigen CD133 using fully-human antibody constructs","volume":"14","author":"Wyszatko","year":"2024","journal-title":"EJNMMI Res."},{"key":"2025010313152036000_66.1.14.20","doi-asserted-by":"crossref","first-page":"334","DOI":"10.1021\/acsomega.1c04711","article-title":"Development of a stable peptide-based PET tracer for detecting CD133-expressing cancer cells","volume":"7","author":"Hu","year":"2022","journal-title":"ACS Omega."},{"key":"2025010313152036000_66.1.14.21","doi-asserted-by":"crossref","first-page":"9061","DOI":"10.2147\/IJN.S262786","article-title":"89Zr-labeled multifunctional liposomes conjugate chitosan for PET-trackable triple-negative breast cancer stem cell targeted therapy","volume":"15","author":"Yang","year":"2020","journal-title":"Int J Nanomedicine."},{"key":"2025010313152036000_66.1.14.22","doi-asserted-by":"crossref","first-page":"3876","DOI":"10.1038\/s41598-021-83496-3","article-title":"89Zr anti-CD44 immuno-PET monitors CD44 expression on splenic myeloid cells and HT29 colon cancer cells","volume":"11","author":"Park","year":"2021","journal-title":"Sci Rep."},{"key":"2025010313152036000_66.1.14.23","doi-asserted-by":"publisher","DOI":"10.2967\/jnumed.120.249557"},{"key":"2025010313152036000_66.1.14.24","doi-asserted-by":"crossref","first-page":"956","DOI":"10.1021\/acs.bioconjchem.2c00164","article-title":"Pretargeted PET imaging with a TCO-conjugated anti-CD44v6 chimeric mAb U36 and [89Zr]Zr-DFO-PEG5-Tz","volume":"33","author":"Lumen","year":"2022","journal-title":"Bioconjug Chem."},{"key":"2025010313152036000_66.1.14.25","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1186\/s13550-020-0597-3","article-title":"Indium-111-labeled CD166-targeted peptide as a potential nuclear imaging agent for detecting colorectal cancer stem-like cells in a xenograft mouse model","volume":"10","author":"Guan","year":"2020","journal-title":"EJNMMI Res."},{"key":"2025010313152036000_66.1.14.26","doi-asserted-by":"crossref","first-page":"1139","DOI":"10.1021\/acs.bioconjchem.1c00188","article-title":"EpCAM-targeting aptamer radiotracer for tumor-specific PET imaging","volume":"32","author":"Li","year":"2021","journal-title":"Bioconjug Chem."},{"key":"2025010313152036000_66.1.14.27","doi-asserted-by":"crossref","first-page":"1810","DOI":"10.1007\/s00259-021-05670-z","article-title":"Preclinical evaluation of [99mTc]Tc-labeled anti-EpCAM nanobody for EpCAM receptor expression imaging by immuno-SPECT\/CT","volume":"49","author":"Liu","year":"2022","journal-title":"Eur J Nucl Med Mol Imaging."},{"key":"2025010313152036000_66.1.14.28","doi-asserted-by":"crossref","first-page":"1594","DOI":"10.2967\/jnumed.120.241877","article-title":"The biodistribution of a CD3 and EpCAM bispecific T-cell engager is driven by the CD3 arm","volume":"61","author":"Suurs","year":"2020","journal-title":"J Nucl Med."},{"key":"2025010313152036000_66.1.14.29","doi-asserted-by":"crossref","first-page":"2345","DOI":"10.1002\/chem.201805473","article-title":"Mapping aldehyde dehydrogenase 1A1 activity using an [18F]substrate-based approach","volume":"25","author":"Pereira","year":"2019","journal-title":"Chemistry."},{"key":"2025010313152036000_66.1.14.30","doi-asserted-by":"crossref","first-page":"561","DOI":"10.1039\/D2CB00040G","article-title":"A prodrug strategy for the in\u00a0vivo imaging of aldehyde dehydrogenase activity","volume":"3","author":"Pereira","year":"2022","journal-title":"RSC Chem Biol."},{"key":"2025010313152036000_66.1.14.31","doi-asserted-by":"crossref","first-page":"5371","DOI":"10.1039\/C9CC01831J","article-title":"Mapping aldehydic load in\u00a0vivo by positron emission tomography with [18F]NA3BF3","volume":"55","author":"Kirby","year":"2019","journal-title":"Chem Commun (Camb)."},{"key":"2025010313152036000_66.1.14.32","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1053\/j.semnuclmed.2023.09.002","article-title":"Advances in PET imaging of the CXCR4 receptor: [68Ga]Ga-PentixaFor","volume":"54","author":"Lindenberg","year":"2024","journal-title":"Semin Nucl Med."},{"key":"2025010313152036000_66.1.14.33","doi-asserted-by":"crossref","first-page":"1612","DOI":"10.3390\/molecules24081612","article-title":"[18F]fluoroethyltriazolyl monocyclam derivatives as imaging probes for the chemokine receptor CXCR4","volume":"24","author":"Amor-Coarasa","year":"2019","journal-title":"Molecules."},{"key":"2025010313152036000_66.1.14.34","doi-asserted-by":"crossref","first-page":"2525037","DOI":"10.1155\/2020\/2525037","article-title":"Tc-CXCR4-L for imaging of the chemokine-4 receptor associated with brain tumor invasiveness: biokinetics, radiation dosimetry, and proof of concept in humans","volume":"2020","author":"Vallejo-Armenta","year":"2020","journal-title":"Contrast Media Mol Imaging."},{"key":"2025010313152036000_66.1.14.35","doi-asserted-by":"crossref","first-page":"3937","DOI":"10.1007\/s00259-023-06395-x","article-title":"[99mTc]Tc-PentixaTec: development, extensive pre-clinical evaluation, and first human experience","volume":"50","author":"Konrad","year":"2023","journal-title":"Eur J Nucl Med Mol Imaging."},{"key":"2025010313152036000_66.1.14.36","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1038\/s41392-024-01851-y","article-title":"Cancer stem cells: advances in knowledge and implications for cancer therapy","volume":"9","author":"Chu","year":"2024","journal-title":"Signal Transduct Target Ther."},{"key":"2025010313152036000_66.1.14.37","doi-asserted-by":"publisher","DOI":"10.2967\/jnumed.119.226134"},{"key":"2025010313152036000_66.1.14.38","doi-asserted-by":"crossref","first-page":"8484","DOI":"10.1021\/acs.jmedchem.3c00131","article-title":"Development of a new class of CXCR4-targeting radioligands based on the endogenous antagonist EPI-X4 for oncological applications","volume":"66","author":"Gaonkar","year":"2023","journal-title":"J Med Chem."},{"key":"2025010313152036000_66.1.14.39","doi-asserted-by":"crossref","first-page":"592","DOI":"10.1097\/RLU.0000000000005194","article-title":"Chemokine receptor 4-targeted PET\/CT with 68Ga-pentixather detects more lesions than 68Ga-pentixafor PET\/CT in multiple myeloma","volume":"49","author":"Yang","year":"2024","journal-title":"Clin Nucl Med."},{"key":"2025010313152036000_66.1.14.40","doi-asserted-by":"crossref","first-page":"567","DOI":"10.1021\/acs.bioconjchem.4c00167","article-title":"18F-radiolabeling and evaluation of an AMD3465 derivative for PET imaging of CXCR4 in a mouse breast tumor model","volume":"35","author":"Li","year":"2024","journal-title":"Bioconjug Chem."}],"container-title":["Journal of Nuclear Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.2967\/jnumed.124.267657","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,1,3]],"date-time":"2025-01-03T21:15:48Z","timestamp":1735938948000},"score":1,"resource":{"primary":{"URL":"http:\/\/jnm.snmjournals.org\/lookup\/doi\/10.2967\/jnumed.124.267657"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,1]]},"references-count":40,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2025,1,3]]},"published-print":{"date-parts":[[2025,1]]}},"alternative-id":["10.2967\/jnumed.124.267657"],"URL":"https:\/\/doi.org\/10.2967\/jnumed.124.267657","relation":{},"ISSN":["0161-5505","2159-662X"],"issn-type":[{"value":"0161-5505","type":"print"},{"value":"2159-662X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,1]]}}}