{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T18:13:34Z","timestamp":1792088014641,"version":"4.4.0"},"reference-count":39,"publisher":"Society of Nuclear Medicine","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Nucl Med"],"accepted":{"date-parts":[[2024,11,14]]},"published-print":{"date-parts":[[2025,1]]},"DOI":"10.2967\/jnumed.124.268457","type":"journal-article","created":{"date-parts":[[2025,1,3]],"date-time":"2025-01-03T16:15:26Z","timestamp":1735920926000},"page":"84-90","source":"Crossref","is-referenced-by-count":14,"title":["Mathematic Modeling of Tumor Growth During [\n                    <sup>177<\/sup>\n                    Lu]Lu-PSMA Therapy: Insights into Treatment Optimization"],"prefix":"10.2967","volume":"66","author":[{"given":"Nouran R.R.","family":"Zaid","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Remco","family":"Bastiaannet","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rob","family":"Hobbs","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"George","family":"Sgouros","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1602","published-online":{"date-parts":[[2025,1,3]]},"reference":[{"key":"2025010313152044000_66.1.84.1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2107322"},{"key":"2025010313152044000_66.1.84.2","doi-asserted-by":"crossref","first-page":"3095","DOI":"10.3390\/cancers13123095","article-title":"Renal safety of [177Lu]Lu-PSMA-617 radioligand therapy in patients with compromised baseline kidney function","volume":"13","author":"Rosar","year":"2021","journal-title":"Cancers (Basel)."},{"key":"2025010313152044000_66.1.84.3","doi-asserted-by":"publisher","DOI":"10.2967\/jnumed.122.265155"},{"key":"2025010313152044000_66.1.84.4","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1186\/s40658-023-00529-8","article-title":"Investigation of image-based lesion and kidney dosimetry protocols for 177Lu-PSMA-I&T therapy with and without a late SPECT\/CT acquisition","volume":"10","author":"Resch","year":"2023","journal-title":"EJNMMI Phys."},{"key":"2025010313152044000_66.1.84.5","doi-asserted-by":"crossref","first-page":"TPS211","DOI":"10.1200\/JCO.2022.40.6_suppl.TPS211","article-title":"PSMAfore: a phase 3 study to compare 177Lu-PSMA-617 treatment with a change in androgen receptor pathway inhibitor in taxane-na\u00efve patients with metastatic castration-resistant prostate cancer [abstract]","volume":"40(suppl)","author":"Sartor","year":"2022","journal-title":"JCO."},{"key":"2025010313152044000_66.1.84.6","doi-asserted-by":"crossref","first-page":"e121","DOI":"10.14694\/EdBook_AM.2014.34.e121","article-title":"The role of preclinical models in radiopharmaceutical therapy","volume":"34","author":"Sgouros","year":"2014","journal-title":"Am Soc Clin Oncol Educ Book."},{"key":"2025010313152044000_66.1.84.7","doi-asserted-by":"publisher","DOI":"10.2967\/jnumed.109.065706"},{"key":"2025010313152044000_66.1.84.8","doi-asserted-by":"crossref","first-page":"2132","DOI":"10.3390\/pharmaceutics13122132","article-title":"A physiologically based pharmacokinetic model for in\u00a0vivo alpha particle generators targeting neuroendocrine tumors in mice","volume":"13","author":"Zaid","year":"2021","journal-title":"Pharmaceutics."},{"key":"2025010313152044000_66.1.84.9","doi-asserted-by":"crossref","first-page":"e0162303","DOI":"10.1371\/journal.pone.0162303","article-title":"Investigating the effect of ligand amount and injected therapeutic activity: a simulation study for 177Lu-labeled PSMA-targeting peptides","volume":"11","author":"Kletting","year":"2016","journal-title":"PLoS One."},{"key":"2025010313152044000_66.1.84.10","doi-asserted-by":"crossref","first-page":"556","DOI":"10.1002\/mp.14622","article-title":"Important pharmacokinetic parameters for individualization of 177Lu\u2010PSMA therapy: a global sensitivity analysis for a physiologically\u2010based pharmacokinetic model","volume":"48","author":"Hardiansyah","year":"2021","journal-title":"Med Phys."},{"key":"2025010313152044000_66.1.84.11","doi-asserted-by":"publisher","DOI":"10.2967\/jnumed.120.245068"},{"key":"2025010313152044000_66.1.84.12","doi-asserted-by":"crossref","first-page":"108004","DOI":"10.1016\/j.cmpb.2023.108004","article-title":"Spatiotemporal modeling of radiopharmaceutical transport in solid tumors: application to 177Lu-PSMA therapy of prostate cancer","volume":"245","author":"Piranfar","year":"2024","journal-title":"Comput Methods Programs Biomed."},{"key":"2025010313152044000_66.1.84.13","doi-asserted-by":"crossref","first-page":"L9\u2013L13","DOI":"10.1088\/0031-9155\/50\/10\/L01","article-title":"The modified linear-quadratic model of Guerrero and Li can be derived from a mechanistic basis and exhibits linear-quadratic-linear behaviour","volume":"50","author":"Carlone","year":"2005","journal-title":"Phys Med Biol."},{"key":"2025010313152044000_66.1.84.14","doi-asserted-by":"publisher","DOI":"10.1259\/0007-1285-58-690-515"},{"key":"2025010313152044000_66.1.84.15","doi-asserted-by":"publisher","DOI":"10.2967\/jnumed.108.058651"},{"key":"2025010313152044000_66.1.84.16","doi-asserted-by":"crossref","first-page":"2721","DOI":"10.3390\/app10082721","article-title":"Review: mathematical modeling of prostate cancer and clinical application","volume":"10","author":"Phan","year":"2020","journal-title":"Appl Sci."},{"key":"2025010313152044000_66.1.84.17","doi-asserted-by":"publisher","DOI":"10.1007\/s11538-015-0110-8"},{"key":"2025010313152044000_66.1.84.18","doi-asserted-by":"crossref","first-page":"4104","DOI":"10.3934\/mbe.2024181","article-title":"Gompertz models with periodical treatment and applications to prostate cancer","volume":"21","author":"Schultz","year":"2024","journal-title":"Math Biosci Eng."},{"key":"2025010313152044000_66.1.84.19","first-page":"473","article-title":"Implication of cell kinetic changes during the progression of human prostatic cancer","volume":"1","author":"Berges","year":"1995","journal-title":"Clin Cancer Res."},{"key":"2025010313152044000_66.1.84.20","doi-asserted-by":"crossref","first-page":"1543","DOI":"10.1016\/j.ijrobp.2018.07.2015","article-title":"Effectiveness of rotating shield brachytherapy for prostate cancer dose escalation and urethral sparing","volume":"102","author":"Adams","year":"2018","journal-title":"Int J Radiat Oncol Biol Phys."},{"key":"2025010313152044000_66.1.84.21","doi-asserted-by":"crossref","first-page":"1778","DOI":"10.1007\/s00259-022-05727-7","article-title":"EANM dosimetry committee recommendations for dosimetry of 177Lu-labelled somatostatin-receptor- and PSMA-targeting ligands","volume":"49","author":"Sj\u00f6green Gleisner","year":"2022","journal-title":"Eur J Nucl Med Mol Imaging."},{"key":"2025010313152044000_66.1.84.22","doi-asserted-by":"publisher","DOI":"10.2967\/jnumed.121.262713"},{"key":"2025010313152044000_66.1.84.23","doi-asserted-by":"publisher","DOI":"10.1186\/s13014-018-1040-z"},{"key":"2025010313152044000_66.1.84.24","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-03-2524"},{"key":"2025010313152044000_66.1.84.25","doi-asserted-by":"publisher","DOI":"10.1118\/1.4752213"},{"key":"2025010313152044000_66.1.84.26","doi-asserted-by":"publisher","DOI":"10.1118\/1.2836421"},{"key":"2025010313152044000_66.1.84.27","doi-asserted-by":"publisher","DOI":"10.2967\/jnumed.115.168443"},{"key":"2025010313152044000_66.1.84.28","doi-asserted-by":"publisher","DOI":"10.2967\/jnumed.123.265448"},{"key":"2025010313152044000_66.1.84.29","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/j.semradonc.2020.07.008","article-title":"Dosimetry for optimized, personalized radiopharmaceutical therapy","volume":"31","author":"Graves","year":"2021","journal-title":"Semin Radiat Oncol."},{"key":"2025010313152044000_66.1.84.30","doi-asserted-by":"publisher","DOI":"10.2967\/jnumed.116.178483"},{"key":"2025010313152044000_66.1.84.31","doi-asserted-by":"publisher","DOI":"10.2967\/jnumed.121.262069"},{"key":"2025010313152044000_66.1.84.32","doi-asserted-by":"crossref","first-page":"460","DOI":"10.1007\/s00259-021-05471-4","article-title":"Intra-therapeutic dosimetry of [177Lu]Lu-PSMA-617 in low-volume hormone-sensitive metastatic prostate cancer patients and correlation with treatment outcome","volume":"49","author":"Peters","year":"2022","journal-title":"Eur J Nucl Med Mol Imaging."},{"key":"2025010313152044000_66.1.84.33","first-page":"1861","article-title":"Application of the linear-quadratic model to radioimmunotherapy: further support for the advantage of longer-lived radionuclides","volume":"35","author":"Howell","year":"1994","journal-title":"J Nucl Med."},{"key":"2025010313152044000_66.1.84.34","doi-asserted-by":"publisher","DOI":"10.1016\/S0146-6453(03)00002-2"},{"key":"2025010313152044000_66.1.84.35","doi-asserted-by":"publisher","DOI":"10.2967\/jnumed.118.210377"},{"key":"2025010313152044000_66.1.84.36","doi-asserted-by":"publisher","DOI":"10.2967\/jnumed.122.264677"},{"key":"2025010313152044000_66.1.84.37","doi-asserted-by":"publisher","DOI":"10.1007\/s00259-023-06255-8"},{"key":"2025010313152044000_66.1.84.38","doi-asserted-by":"publisher","DOI":"10.2967\/jnumed.123.265986"},{"key":"2025010313152044000_66.1.84.39","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1016\/j.eururo.2020.05.004","article-title":"Efficacy and safety of 177Lu-labeled prostate-specific membrane antigen radionuclide treatment in patients with diffuse bone marrow involvement: a multicenter retrospective study","volume":"78","author":"Gafita","year":"2020","journal-title":"Eur Urol."}],"container-title":["Journal of Nuclear Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.2967\/jnumed.124.268457","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,1,3]],"date-time":"2025-01-03T16:16:28Z","timestamp":1735920988000},"score":1,"resource":{"primary":{"URL":"http:\/\/jnm.snmjournals.org\/lookup\/doi\/10.2967\/jnumed.124.268457"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,1]]},"references-count":39,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2025,1,3]]},"published-print":{"date-parts":[[2025,1]]}},"alternative-id":["10.2967\/jnumed.124.268457"],"URL":"https:\/\/doi.org\/10.2967\/jnumed.124.268457","relation":{},"ISSN":["0161-5505","2159-662X"],"issn-type":[{"value":"0161-5505","type":"print"},{"value":"2159-662X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,1]]}}}