{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,8]],"date-time":"2026-04-08T19:02:32Z","timestamp":1775674952174,"version":"3.50.1"},"reference-count":30,"publisher":"Society of Nuclear Medicine","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Nucl Med"],"accepted":{"date-parts":[[2025,3,12]]},"published-print":{"date-parts":[[2025,5]]},"DOI":"10.2967\/jnumed.124.268519","type":"journal-article","created":{"date-parts":[[2025,4,3]],"date-time":"2025-04-03T18:02:09Z","timestamp":1743703329000},"page":"764-770","source":"Crossref","is-referenced-by-count":2,"title":["Validating the Utility of Supervised Clustering Algorithm for Precise [<sup>11<\/sup>C]DPA-713 PET Brain Image Quantification"],"prefix":"10.2967","volume":"66","author":[{"given":"Youjin","family":"Lee","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thanh D.","family":"Nguyen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yong","family":"Du","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jennifer M.","family":"Coughlin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sara A.","family":"Zein","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nicolas A.","family":"Karakatsanis","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sadek","family":"Nehmeh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Martin G.","family":"Pomper","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Susan A.","family":"Gauthier","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yeona","family":"Kang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1602","published-online":{"date-parts":[[2025,4,3]]},"reference":[{"key":"2025050105251686000_66.5.764.1","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1186\/s40035-020-00221-2","article-title":"Neuroinflammation in neurodegenerative disorders: the roles of microglia and astrocytes","volume":"9","author":"Kwon","year":"2020","journal-title":"Transl Neurodegener."},{"key":"2025050105251686000_66.5.764.2","doi-asserted-by":"publisher","DOI":"10.1016\/j.semcdb.2019.05.004"},{"key":"2025050105251686000_66.5.764.3","doi-asserted-by":"crossref","first-page":"3391","DOI":"10.3892\/mmr.2016.4948","article-title":"Role of neuroinflammation in neurodegenerative diseases","volume":"13","author":"Chen","year":"2016","journal-title":"Mol Med Rep."},{"key":"2025050105251686000_66.5.764.4","doi-asserted-by":"publisher","DOI":"10.1007\/s00259-020-05166-2"},{"key":"2025050105251686000_66.5.764.5","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbi.2023.07.023"},{"key":"2025050105251686000_66.5.764.6","doi-asserted-by":"crossref","first-page":"940","DOI":"10.1016\/S1474-4422(20)30346-X","article-title":"PET imaging of neuroinflammation in neurological disorders","volume":"19","author":"Kreisl","year":"2020","journal-title":"Lancet Neurol."},{"key":"2025050105251686000_66.5.764.7","doi-asserted-by":"publisher","DOI":"10.2967\/jnumed.109.063206"},{"key":"2025050105251686000_66.5.764.8","doi-asserted-by":"publisher","DOI":"10.1097\/00004647-199807000-00002"},{"key":"2025050105251686000_66.5.764.9","doi-asserted-by":"crossref","first-page":"1636","DOI":"10.1007\/s00259-022-06057-4","article-title":"Non-invasive kinetic modelling approaches for quantitative analysis of brain PET studies","volume":"50","author":"van der Weijden","year":"2023","journal-title":"Eur J Nucl Med Mol Imaging."},{"key":"2025050105251686000_66.5.764.10","first-page":"158","article-title":"Reference and target region modeling of [11C]-(R)-PK11195 brain studies","volume":"48","author":"Turkheimer","year":"2007","journal-title":"J Nucl Med."},{"key":"2025050105251686000_66.5.764.11","doi-asserted-by":"publisher","DOI":"10.1007\/s00259-021-05309-z"},{"key":"2025050105251686000_66.5.764.12","doi-asserted-by":"publisher","DOI":"10.1007\/s11307-009-0211-6"},{"key":"2025050105251686000_66.5.764.13","doi-asserted-by":"publisher","DOI":"10.2967\/jnumed.109.062265"},{"key":"2025050105251686000_66.5.764.14","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1177\/0271678X17699223","article-title":"11C-DPA-713 has much greater specific binding to translocator protein 18 kDa (TSPO) in human brain than 11C-(R)-PK11195","volume":"38","author":"Kobayashi","year":"2018","journal-title":"J Cereb Blood Flow Metab."},{"key":"2025050105251686000_66.5.764.15","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1186\/s13550-017-0334-8","article-title":"Comparison of four 11C-labeled PET ligands to quantify translocator protein 18 kDa (TSPO) in human brain: (R)-PK11195, PBR28, DPA-713, and ER176\u2014based on recent publications that measured specific-to-non-displaceable ratios","volume":"7","author":"Fujita","year":"2017","journal-title":"EJNMMI Res."},{"key":"2025050105251686000_66.5.764.16","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1186\/s13550-018-0455-8","article-title":"Test\u2013retest reliability and convergent validity of (R)-[11C] PK11195 outcome measures without arterial input function","volume":"8","author":"Plav\u00e9n-Sigray","year":"2018","journal-title":"EJNMMI Res."},{"key":"2025050105251686000_66.5.764.17","doi-asserted-by":"publisher","DOI":"10.2967\/jnumed.118.222927"},{"key":"2025050105251686000_66.5.764.18","doi-asserted-by":"publisher","DOI":"10.1177\/0271678x17692599"},{"key":"2025050105251686000_66.5.764.19","doi-asserted-by":"publisher","DOI":"10.3109\/14639239809001400"},{"key":"2025050105251686000_66.5.764.20","doi-asserted-by":"publisher","DOI":"10.1006\/nimg.1998.0395"},{"key":"2025050105251686000_66.5.764.21","doi-asserted-by":"publisher","DOI":"10.1097\/00004647-199609000-00008"},{"key":"2025050105251686000_66.5.764.22","doi-asserted-by":"publisher","DOI":"10.1038\/jcbfm.1990.127"},{"key":"2025050105251686000_66.5.764.23","doi-asserted-by":"publisher","DOI":"10.1037\/0033-2909.86.2.420"},{"key":"2025050105251686000_66.5.764.24","first-page":"307","article-title":"Measurement in medicine: the analysis of method comparison studies","volume":"32","author":"Altman","year":"1983","journal-title":"J R Stat Soc, Ser. D."},{"key":"2025050105251686000_66.5.764.25","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijnurstu.2009.10.001"},{"key":"2025050105251686000_66.5.764.26","doi-asserted-by":"crossref","first-page":"496","DOI":"10.1016\/j.acra.2015.12.020","article-title":"Statistical issues in testing conformance with the quantitative imaging biomarker alliance (QIBA) profile claims","volume":"23","author":"Obuchowski","year":"2016","journal-title":"Acad Radiol."},{"key":"2025050105251686000_66.5.764.27","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1007\/s00259-021-05601-y","article-title":"Imaging translocator protein expression with positron emission tomography","volume":"49","author":"Wimberley","year":"2021","journal-title":"Eur J Nucl Med Mol Imaging."},{"key":"2025050105251686000_66.5.764.28","doi-asserted-by":"publisher","DOI":"10.1042\/BST20150058"},{"key":"2025050105251686000_66.5.764.29","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1007\/s40336-015-0138-7","article-title":"Challenges of quantification of TSPO in the human brain","volume":"3","author":"Hinz","year":"2015","journal-title":"Clin Transl Imaging."},{"key":"2025050105251686000_66.5.764.30","doi-asserted-by":"crossref","first-page":"e0201289","DOI":"10.1371\/journal.pone.0201289","article-title":"Comparison of two different methods of image analysis for the assessment of microglial activation in patients with multiple sclerosis using (R)-[N-methyl-carbon-11] PK11195","volume":"13","author":"Kang","year":"2018","journal-title":"PLoS One."}],"container-title":["Journal of Nuclear Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.2967\/jnumed.124.268519","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,5,1]],"date-time":"2025-05-01T12:26:29Z","timestamp":1746102389000},"score":1,"resource":{"primary":{"URL":"http:\/\/jnm.snmjournals.org\/lookup\/doi\/10.2967\/jnumed.124.268519"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,4,3]]},"references-count":30,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2025,5,1]]},"published-print":{"date-parts":[[2025,5]]}},"alternative-id":["10.2967\/jnumed.124.268519"],"URL":"https:\/\/doi.org\/10.2967\/jnumed.124.268519","relation":{},"ISSN":["0161-5505","2159-662X"],"issn-type":[{"value":"0161-5505","type":"print"},{"value":"2159-662X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,4,3]]}}}