{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,31]],"date-time":"2026-10-31T14:42:06Z","timestamp":1793457726313,"version":"4.5.0"},"reference-count":31,"publisher":"Society of Nuclear Medicine","issue":"10","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Nucl Med"],"accepted":{"date-parts":[[2025,7,28]]},"published-print":{"date-parts":[[2025,10]]},"DOI":"10.2967\/jnumed.125.269495","type":"journal-article","created":{"date-parts":[[2025,8,28]],"date-time":"2025-08-28T16:35:12Z","timestamp":1756398912000},"page":"1639-1645","source":"Crossref","is-referenced-by-count":9,"title":["Randomized Phase 2 Trial of an Extended and Flexible Dosing Schedule of <sup>177<\/sup>Lu-PSMA Molecular Radiotherapy in Patients with Metastatic Castration-Resistant Prostate Cancer (FLEX-MRT): Study Protocol"],"prefix":"10.2967","volume":"66","author":[{"given":"Adrien","family":"Holzgreve","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Astrid","family":"Delker","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zachary","family":"Ells","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julia","family":"Brosch-Lenz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lena M.","family":"Unterrainer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John","family":"Nikitas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shaojun","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria M.","family":"Contreras","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hamzah","family":"Alam","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rejah M.","family":"Nabong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephanie","family":"Lira","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arseniy","family":"Vasilyev","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lillian","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tristan","family":"Grogan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Elashoff","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Catherine A.","family":"Meyer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Magnus","family":"Dahlbom","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Johannes","family":"Czernin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J\u00e9r\u00e9mie","family":"Calais","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1602","published-online":{"date-parts":[[2025,8,28]]},"reference":[{"key":"2025100106250828000_66.10.1639.1","doi-asserted-by":"publisher","DOI":"10.1038\/d41573-022-00068-4"},{"key":"2025100106250828000_66.10.1639.2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2107322"},{"key":"2025100106250828000_66.10.1639.3","doi-asserted-by":"crossref","first-page":"597","DOI":"10.1016\/S1470-2045(23)00158-4","article-title":"Health-related quality of life and pain outcomes with [177Lu]Lu-PSMA-617 plus standard of care versus standard of care in patients with metastatic castration-resistant prostate cancer (VISION): a multicentre, open-label, randomised, phase 3 trial","volume":"24","author":"Fizazi","year":"2023","journal-title":"Lancet Oncol."},{"key":"2025100106250828000_66.10.1639.4","doi-asserted-by":"publisher","DOI":"10.2967\/jnumed.122.264293"},{"key":"2025100106250828000_66.10.1639.5","doi-asserted-by":"publisher","DOI":"10.2967\/jnumed.118.215715"},{"key":"2025100106250828000_66.10.1639.6","doi-asserted-by":"crossref","first-page":"4151","DOI":"10.1007\/s00259-024-06825-4","article-title":"Efficacy and safety of rechallenge [177Lu]Lu-PSMA-617 RLT after initial partial remission in patients with mCRPC: evaluation of a prospective registry (REALITY study)","volume":"51","author":"Rosar","year":"2024","journal-title":"Eur J Nucl Med Mol Imaging."},{"key":"2025100106250828000_66.10.1639.7","doi-asserted-by":"publisher","DOI":"10.2967\/jnumed.123.267321"},{"key":"2025100106250828000_66.10.1639.8","doi-asserted-by":"publisher","DOI":"10.2967\/jnumed.119.236414"},{"key":"2025100106250828000_66.10.1639.9","doi-asserted-by":"crossref","first-page":"1073","DOI":"10.1007\/s00259-018-4222-x","article-title":"Outcome and safety of rechallenge [177Lu]Lu-PSMA-617 in patients with metastatic prostate cancer","volume":"46","author":"Yordanova","year":"2019","journal-title":"Eur J Nucl Med Mol Imaging."},{"key":"2025100106250828000_66.10.1639.10","doi-asserted-by":"crossref","first-page":"17588359231156392","DOI":"10.1177\/17588359231156392","article-title":"Patient outcomes following a response biomarker-guided approach to treatment using 177Lu-PSMA-I&T in men with metastatic castrate-resistant prostate cancer (Re-SPECT)","volume":"15","author":"Emmett","year":"2023","journal-title":"Ther Adv Med Oncol."},{"key":"2025100106250828000_66.10.1639.11","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2022.21243"},{"key":"2025100106250828000_66.10.1639.12","doi-asserted-by":"publisher","DOI":"10.2967\/jnumed.122.264398"},{"key":"2025100106250828000_66.10.1639.13","doi-asserted-by":"publisher","DOI":"10.2967\/jnumed.121.263072"},{"key":"2025100106250828000_66.10.1639.14","doi-asserted-by":"publisher","DOI":"10.2967\/jnumed.122.264946"},{"key":"2025100106250828000_66.10.1639.15","doi-asserted-by":"publisher","DOI":"10.2967\/jnumed.122.264594"},{"key":"2025100106250828000_66.10.1639.16","doi-asserted-by":"publisher","DOI":"10.1016\/j.jbi.2008.08.010"},{"key":"2025100106250828000_66.10.1639.17","doi-asserted-by":"crossref","first-page":"12477","DOI":"10.18632\/oncotarget.7245","article-title":"Therapeutic response and side effects of repeated radioligand therapy with 177Lu-PSMA-DKFZ-617 of castrate-resistant metastatic prostate cancer","volume":"7","author":"Ahmadzadehfar","year":"2016","journal-title":"Oncotarget."},{"key":"2025100106250828000_66.10.1639.18","doi-asserted-by":"publisher","DOI":"10.2967\/jnumed.115.171397"},{"key":"2025100106250828000_66.10.1639.19","doi-asserted-by":"publisher","DOI":"10.2967\/jnumed.116.183194"},{"key":"2025100106250828000_66.10.1639.20","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1213755"},{"key":"2025100106250828000_66.10.1639.21","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1607427"},{"key":"2025100106250828000_66.10.1639.22","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2002.11.076"},{"key":"2025100106250828000_66.10.1639.23","doi-asserted-by":"publisher","DOI":"10.1007\/s00259-015-3174-7"},{"key":"2025100106250828000_66.10.1639.24","doi-asserted-by":"publisher","DOI":"10.1007\/s00259-015-3125-3"},{"key":"2025100106250828000_66.10.1639.25","doi-asserted-by":"publisher","DOI":"10.1016\/0360-3016(91)90171-Y"},{"key":"2025100106250828000_66.10.1639.26","doi-asserted-by":"publisher","DOI":"10.2967\/jnumed.121.262543"},{"key":"2025100106250828000_66.10.1639.27","doi-asserted-by":"publisher","DOI":"10.2967\/jnumed.122.264677"},{"key":"2025100106250828000_66.10.1639.28","doi-asserted-by":"crossref","first-page":"1185","DOI":"10.1007\/s00259-023-06536-2","article-title":"Early response monitoring during [177Lu]Lu-PSMA I&T therapy with quantitated SPECT\/CT predicts overall survival of mCRPC patients: subgroup analysis of a Swiss-wide prospective registry study","volume":"51","author":"Neubauer","year":"2024","journal-title":"Eur J Nucl Med Mol Imaging."},{"key":"2025100106250828000_66.10.1639.29","doi-asserted-by":"crossref","first-page":"2250","DOI":"10.1007\/s00259-023-06176-6","article-title":"SPECT at the speed of PET: a feasibility study of CZT-based whole-body SPECT\/CT in the post 177Lu-DOTATATE and 177Lu-PSMA617 setting","volume":"50","author":"Song","year":"2023","journal-title":"Eur J Nucl Med Mol Imaging."},{"key":"2025100106250828000_66.10.1639.30","doi-asserted-by":"crossref","first-page":"2784","DOI":"10.1007\/s00259-024-06718-6","article-title":"Same-day post-therapy imaging with a new generation whole-body digital SPECT\/CT in assessing treatment response to [177Lu]Lu-PSMA-617 in metastatic castration-resistant prostate cancer","volume":"51","author":"Song","year":"2024","journal-title":"Eur J Nucl Med Mol Imaging."},{"key":"2025100106250828000_66.10.1639.31","doi-asserted-by":"crossref","first-page":"1291253","DOI":"10.3389\/fnume.2023.1291253","article-title":"Quantitative imaging for 177Lu-PSMA treatment response monitoring and dosimetry","volume":"3","author":"Meyer","year":"2023","journal-title":"Front Nucl Med."}],"container-title":["Journal of Nuclear Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.2967\/jnumed.125.269495","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T13:25:29Z","timestamp":1759325129000},"score":1,"resource":{"primary":{"URL":"http:\/\/jnm.snmjournals.org\/lookup\/doi\/10.2967\/jnumed.125.269495"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,8,28]]},"references-count":31,"journal-issue":{"issue":"10","published-online":{"date-parts":[[2025,10,1]]},"published-print":{"date-parts":[[2025,10]]}},"alternative-id":["10.2967\/jnumed.125.269495"],"URL":"https:\/\/doi.org\/10.2967\/jnumed.125.269495","relation":{},"ISSN":["0161-5505","2159-662X"],"issn-type":[{"value":"0161-5505","type":"print"},{"value":"2159-662X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,8,28]]}}}