{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,20]],"date-time":"2025-11-20T13:17:34Z","timestamp":1763644654833,"version":"3.40.5"},"reference-count":27,"publisher":"Society of Nuclear Medicine","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Nucl Med"],"accepted":{"date-parts":[[2025,4,21]]},"DOI":"10.2967\/jnumed.125.269533","type":"journal-article","created":{"date-parts":[[2025,5,15]],"date-time":"2025-05-15T16:05:13Z","timestamp":1747325113000},"page":"jnumed.125.269533","source":"Crossref","is-referenced-by-count":1,"title":["Designed Ankyrin Repeat Protein\u2013Mediated Peptide Nucleic Acid\u2013Based Pretargeting: A Proof-of-Principle Study"],"prefix":"10.2967","author":[{"given":"Maryam","family":"Oroujeni","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kristina","family":"Westerlund","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eleftherios","family":"Papalanis","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alexander","family":"van Deventer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yongsheng","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jacob","family":"Clinton","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhengyue","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ivan","family":"Zelepukin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anna","family":"Orlova","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vladimir","family":"Tolmachev","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amelie","family":"Eriksson Karlstr\u00f6m","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1602","published-online":{"date-parts":[[2025,5,15]]},"reference":[{"key":"2025051509050788000_jnumed.125.269533v1.1","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1007\/978-1-4939-7893-9_23","article-title":"Advances in the application of designed ankyrin repeat proteins (DARPins) as research tools and protein therapeutics","volume":"1798","author":"Boersma","year":"2018","journal-title":"Methods Mol Biol."},{"key":"2025051509050788000_jnumed.125.269533v1.2","doi-asserted-by":"publisher","DOI":"10.2967\/jnumed.121.262542"},{"key":"2025051509050788000_jnumed.125.269533v1.3","doi-asserted-by":"crossref","first-page":"2815","DOI":"10.3390\/cancers16162815","article-title":"Phase I clinical evaluation of designed ankyrin repeat protein [99mTc]Tc(CO)3-(HE)3-Ec1 for visualization of EpCAM-expressing lung cancer","volume":"16","author":"Zelchan","year":"2024","journal-title":"Cancers (Basel)."},{"key":"2025051509050788000_jnumed.125.269533v1.4","doi-asserted-by":"publisher","DOI":"10.1186\/s41181-020-00094-w"},{"key":"2025051509050788000_jnumed.125.269533v1.5","doi-asserted-by":"crossref","first-page":"2673","DOI":"10.3390\/molecules25112673","article-title":"Influence of several compounds and drugs on the renal uptake of radiolabeled affibody molecules","volume":"25","author":"Garousi","year":"2020","journal-title":"Molecules."},{"key":"2025051509050788000_jnumed.125.269533v1.6","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1186\/s13550-020-0599-1","article-title":"On the prevention of kidney uptake of radiolabeled DARPins","volume":"10","author":"Altai","year":"2020","journal-title":"EJNMMI Res."},{"key":"2025051509050788000_jnumed.125.269533v1.7","doi-asserted-by":"publisher","DOI":"10.2967\/jnumed.115.162248"},{"key":"2025051509050788000_jnumed.125.269533v1.8","doi-asserted-by":"crossref","first-page":"93","DOI":"10.7150\/thno.12766","article-title":"Feasibility of Affibody molecule-based PNA-mediated radionuclide pretargeting of malignant tumors","volume":"6","author":"Honarvar","year":"2016","journal-title":"Theranostics."},{"key":"2025051509050788000_jnumed.125.269533v1.9","doi-asserted-by":"publisher","DOI":"10.1038\/365566a0"},{"key":"2025051509050788000_jnumed.125.269533v1.10","doi-asserted-by":"publisher","DOI":"10.1016\/0006-2952(94)90171-6"},{"key":"2025051509050788000_jnumed.125.269533v1.11","doi-asserted-by":"publisher","DOI":"10.2967\/jnumed.118.208348"},{"key":"2025051509050788000_jnumed.125.269533v1.12","doi-asserted-by":"publisher","DOI":"10.2967\/jnumed.121.262123"},{"key":"2025051509050788000_jnumed.125.269533v1.13","doi-asserted-by":"crossref","first-page":"1724","DOI":"10.1021\/acs.bioconjchem.5b00292","article-title":"Design, preparation, and characterization of PNA-based hybridization probes for Affibody-molecule-mediated pretargeting","volume":"26","author":"Westerlund","year":"2015","journal-title":"Bioconjugate Chem."},{"key":"2025051509050788000_jnumed.125.269533v1.14","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.nucmedbio.2017.07.003","article-title":"Evaluation of Affibody molecule-based PNA-mediated radionuclide pretargeting: development of an optimized conjugation protocol and 177Lu labeling","volume":"54","author":"Altai","year":"2017","journal-title":"Nucl Med Biol."},{"key":"2025051509050788000_jnumed.125.269533v1.15","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmb.2007.03.028"},{"key":"2025051509050788000_jnumed.125.269533v1.16","doi-asserted-by":"publisher","DOI":"10.1038\/nbt916"},{"key":"2025051509050788000_jnumed.125.269533v1.17","doi-asserted-by":"crossref","first-page":"4246","DOI":"10.3390\/ijms25084246","article-title":"Preclinical evaluation of HER2-targeting DARPin G3: impact of albumin-binding domain (ABD) fusion","volume":"25","author":"Deyev","year":"2024","journal-title":"Int J Mol Sci."},{"key":"2025051509050788000_jnumed.125.269533v1.18","doi-asserted-by":"crossref","first-page":"4038","DOI":"10.1007\/s00259-024-06840-5","article-title":"Evaluation of a novel 177Lu-labelled therapeutic Affibody molecule with a deimmunized ABD domain and improved biodistribution profile","volume":"51","author":"Liu","year":"2024","journal-title":"Eur J Nucl Med Mol Imaging."},{"key":"2025051509050788000_jnumed.125.269533v1.19","doi-asserted-by":"publisher","DOI":"10.2967\/jnumed.121.262186"},{"key":"2025051509050788000_jnumed.125.269533v1.20","doi-asserted-by":"publisher","DOI":"10.2967\/jnumed.115.159145"},{"key":"2025051509050788000_jnumed.125.269533v1.21","doi-asserted-by":"publisher","DOI":"10.2967\/jnumed.124.267624"},{"key":"2025051509050788000_jnumed.125.269533v1.22","doi-asserted-by":"publisher","DOI":"10.1021\/acs.bioconjchem.3c00286"},{"key":"2025051509050788000_jnumed.125.269533v1.23","doi-asserted-by":"crossref","first-page":"9405","DOI":"10.1038\/s41598-019-45795-8","article-title":"Optimal composition and position of histidine-containing tags improves biodistribution of 99mTc-labeled DARPin G3","volume":"9","author":"Vorobyeva","year":"2019","journal-title":"Sci Rep."},{"key":"2025051509050788000_jnumed.125.269533v1.24","doi-asserted-by":"publisher","DOI":"10.1016\/j.str.2013.08.020"},{"key":"2025051509050788000_jnumed.125.269533v1.25","doi-asserted-by":"crossref","first-page":"833","DOI":"10.3390\/pharmaceutics15030833","article-title":"Targeted two-step delivery of oncotheranostic nano-PLGA for HER2-positive tumor imaging and therapy in\u00a0vivo: improved effectiveness compared to one-step strategy","volume":"15","author":"Shipunova","year":"2023","journal-title":"Pharmaceutics."},{"key":"2025051509050788000_jnumed.125.269533v1.26","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1016\/j.biochi.2024.09.011","article-title":"The Barnase-Barstar-based pre-targeting strategy for enhanced antitumor therapy in\u00a0vivo","volume":"228","author":"Proshkina","year":"2025","journal-title":"Biochimie."},{"key":"2025051509050788000_jnumed.125.269533v1.27","doi-asserted-by":"publisher","DOI":"10.1158\/1535-7163.MCT-09-0195"}],"container-title":["Journal of Nuclear Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.2967\/jnumed.125.269533","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,5,15]],"date-time":"2025-05-15T16:05:15Z","timestamp":1747325115000},"score":1,"resource":{"primary":{"URL":"http:\/\/jnm.snmjournals.org\/lookup\/doi\/10.2967\/jnumed.125.269533"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,5,15]]},"references-count":27,"alternative-id":["10.2967\/jnumed.125.269533"],"URL":"https:\/\/doi.org\/10.2967\/jnumed.125.269533","relation":{},"ISSN":["0161-5505","2159-662X"],"issn-type":[{"value":"0161-5505","type":"print"},{"value":"2159-662X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,5,15]]}}}