{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,12]],"date-time":"2026-09-12T06:27:13Z","timestamp":1789194433078,"version":"build-2803163510"},"reference-count":28,"publisher":"Society of Nuclear Medicine","issue":"9","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Nucl Med"],"accepted":{"date-parts":[[2025,7,14]]},"published-print":{"date-parts":[[2025,9]]},"DOI":"10.2967\/jnumed.125.270132","type":"journal-article","created":{"date-parts":[[2025,8,7]],"date-time":"2025-08-07T17:20:15Z","timestamp":1754587215000},"page":"1365-1371","source":"Crossref","is-referenced-by-count":9,"title":["[<sup>64<\/sup>Cu]Cu-NOTA-EV-F(ab\u2032)<sub>2<\/sub> Enables Same-Day Immuno-PET Imaging of Nectin-4 in Triple-Negative Breast and Urothelial Bladder Cancers"],"prefix":"10.2967","volume":"66","author":[{"given":"Wenpeng","family":"Huang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liming","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fangfang","family":"Chao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qi","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jason C.","family":"Mixdorf","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonathan W.","family":"Engle","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jessica C.","family":"Hsu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lei","family":"Kang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weibo","family":"Cai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1602","published-online":{"date-parts":[[2025,8,7]]},"reference":[{"key":"2025090310401689000_66.9.1365.1","doi-asserted-by":"crossref","first-page":"115545","DOI":"10.1016\/j.bcp.2023.115545","article-title":"Triple-negative breast cancer: epidemiology, molecular mechanisms, and modern vaccine-based treatment strategies","volume":"212","author":"Karim","year":"2023","journal-title":"Biochem Pharmacol."},{"key":"2025090310401689000_66.9.1365.2","doi-asserted-by":"crossref","unstructured":"Abidoye O Jain P Singh P . Lines of therapy for locally advanced\/metastatic urothelial carcinoma: the new paradigm. JCO Oncol Pract. 2025:OP-24-00758.","DOI":"10.1200\/OP-24-00758"},{"key":"2025090310401689000_66.9.1365.3","doi-asserted-by":"publisher","DOI":"10.1016\/j.semcancer.2020.06.005"},{"key":"2025090310401689000_66.9.1365.4","doi-asserted-by":"crossref","first-page":"e250250","DOI":"10.1001\/jamanetworkopen.2025.0250","article-title":"Enfortumab vedotin with or without pembrolizumab in metastatic urothelial carcinoma: a systematic review and meta-analysis","volume":"8","author":"Yajima","year":"2025","journal-title":"JAMA Netw Open."},{"key":"2025090310401689000_66.9.1365.5","doi-asserted-by":"crossref","first-page":"3468","DOI":"10.1021\/acs.molpharmaceut.5c00469","article-title":"ImmunoPET imaging of nectin4 expression in gastric and bladder cancer using [64Cu]Cu-NOTA-Padcev","volume":"22","author":"Huang","year":"2025","journal-title":"Mol Pharmaceutics."},{"key":"2025090310401689000_66.9.1365.6","doi-asserted-by":"crossref","first-page":"3223","DOI":"10.1007\/s00259-025-07167-5","article-title":"ImmunoPET imaging of Trop2 expression in triple-negative breast cancer using [64Cu]Cu-NOTA-Trodelvy-F(ab\u2032)2","volume":"52","author":"Huang","year":"2025","journal-title":"Eur J Nucl Med Mol Imaging."},{"key":"2025090310401689000_66.9.1365.7","doi-asserted-by":"publisher","DOI":"10.3390\/v6062268"},{"key":"2025090310401689000_66.9.1365.8","doi-asserted-by":"publisher","DOI":"10.1016\/j.canlet.2016.02.049"},{"key":"2025090310401689000_66.9.1365.9","doi-asserted-by":"crossref","first-page":"176129","DOI":"10.1016\/j.ejphar.2023.176129","article-title":"Nectin-4 has emerged as a compelling target for breast cancer","volume":"960","author":"Wang","year":"2023","journal-title":"Eur J Pharmacol."},{"key":"2025090310401689000_66.9.1365.10","doi-asserted-by":"crossref","first-page":"2865","DOI":"10.3390\/cancers15102865","article-title":"Nectin-4 as a predictive marker for poor prognosis of endometrial cancer with mismatch repair impairment","volume":"15","author":"Chang","year":"2023","journal-title":"Cancers (Basel)."},{"key":"2025090310401689000_66.9.1365.11","doi-asserted-by":"publisher","DOI":"10.1186\/s13046-015-0144-7"},{"key":"2025090310401689000_66.9.1365.12","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-09-0016"},{"key":"2025090310401689000_66.9.1365.13","doi-asserted-by":"crossref","first-page":"200","DOI":"10.3389\/fmed.2019.00200","article-title":"Nectin-4 expression is an independent prognostic biomarker and associated with better survival in triple-negative breast cancer","volume":"6","author":"Zeindler","year":"2019","journal-title":"Front Med (Lausanne)."},{"key":"2025090310401689000_66.9.1365.14","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2035807.Epub"},{"key":"2025090310401689000_66.9.1365.15","doi-asserted-by":"crossref","first-page":"122910","DOI":"10.1016\/j.lfs.2024.122910","article-title":"Nectin-4-directed antibody\u2013drug conjugates (ADCs): spotlight on preclinical and clinical evidence","volume":"352","author":"Khosravanian","year":"2024","journal-title":"Life Sci."},{"key":"2025090310401689000_66.9.1365.16","doi-asserted-by":"crossref","first-page":"863","DOI":"10.1080\/14712598.2021.1929168","article-title":"Targeting nectin-4 by antibody-drug conjugates for the treatment of urothelial carcinoma","volume":"21","author":"Wong","year":"2021","journal-title":"Expert Opin Biol Ther."},{"key":"2025090310401689000_66.9.1365.17","doi-asserted-by":"crossref","first-page":"2266","DOI":"10.1021\/acs.molpharmaceut.5c00069","article-title":"ImmunoPET imaging of Trop2 expression in bladder cancer using [64Cu]Cu-NOTA-Trodelvy","volume":"22","author":"Huang","year":"2025","journal-title":"Mol Pharmaceutics."},{"key":"2025090310401689000_66.9.1365.18","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1186\/s12951-022-01444-3","article-title":"Nectin-4-targeted immunoSPECT\/CT imaging and photothermal therapy of triple-negative breast cancer","volume":"20","author":"Shao","year":"2022","journal-title":"J Nanobiotechnology."},{"key":"2025090310401689000_66.9.1365.19","doi-asserted-by":"publisher","DOI":"10.2967\/jnumed.120.246595"},{"key":"2025090310401689000_66.9.1365.20","doi-asserted-by":"crossref","first-page":"1061","DOI":"10.2174\/1389201022666210810104226","article-title":"Antibody fragment and targeted colorectal cancer therapy: a global systematic review","volume":"23","author":"Ghani","year":"2022","journal-title":"Curr Pharm Biotechnol."},{"key":"2025090310401689000_66.9.1365.21","doi-asserted-by":"crossref","first-page":"1791","DOI":"10.1007\/s00259-024-07036-7","article-title":"CD38-specific immunoPET imaging for multiple myeloma diagnosis and therapeutic monitoring: preclinical and first-in-human studies","volume":"52","author":"Huang","year":"2025","journal-title":"Eur J Nucl Med Mol Imaging."},{"key":"2025090310401689000_66.9.1365.22","doi-asserted-by":"crossref","first-page":"2369","DOI":"10.1007\/s00259-025-07106-4","article-title":"Preclinical evaluation of zirconium-89 labeled anti-Trop2 antibody\u2013drug conjugate (Trodelvy) for imaging in gastric cancer and triple-negative breast cancer","volume":"52","author":"Huang","year":"2025","journal-title":"Eur J Nucl Med Mol Imaging."},{"key":"2025090310401689000_66.9.1365.23","doi-asserted-by":"publisher","DOI":"10.1007\/s00259-021-05593-9"},{"key":"2025090310401689000_66.9.1365.24","doi-asserted-by":"crossref","first-page":"110795","DOI":"10.1016\/j.apradiso.2023.110795","article-title":"Biochemical separation of cetuximab-Fab\u2032 from papain-digested antibody fragments and radiolabeling with 64Cu for potential use in radioimmunotheranostics","volume":"196","author":"Chakravarty","year":"2023","journal-title":"Appl Radiat Isot."},{"key":"2025090310401689000_66.9.1365.25","doi-asserted-by":"publisher","DOI":"10.1007\/s11307-016-0953-x"},{"key":"2025090310401689000_66.9.1365.26","doi-asserted-by":"crossref","first-page":"123756","DOI":"10.1016\/j.ijpharm.2023.123756","article-title":"An iodine-labelled antibody\u2013drug conjugate PET probe for noninvasive monitoring of nectin-4 expression in urothelial carcinoma","volume":"651","author":"Ren","year":"2024","journal-title":"Int J Pharm."},{"key":"2025090310401689000_66.9.1365.27","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1007\/s11307-019-01386-7","article-title":"[89Zr]A2cDb immuno-PET of prostate cancer in a human prostate stem cell antigen knock-in (hPSCA KI) syngeneic model","volume":"22","author":"Zettlitz","year":"2020","journal-title":"Mol Imaging Biol."},{"key":"2025090310401689000_66.9.1365.28","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-18-0123"}],"container-title":["Journal of Nuclear Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.2967\/jnumed.125.270132","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,9,3]],"date-time":"2025-09-03T17:41:00Z","timestamp":1756921260000},"score":1,"resource":{"primary":{"URL":"http:\/\/jnm.snmjournals.org\/lookup\/doi\/10.2967\/jnumed.125.270132"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,8,7]]},"references-count":28,"journal-issue":{"issue":"9","published-online":{"date-parts":[[2025,9,2]]},"published-print":{"date-parts":[[2025,9]]}},"alternative-id":["10.2967\/jnumed.125.270132"],"URL":"https:\/\/doi.org\/10.2967\/jnumed.125.270132","relation":{},"ISSN":["0161-5505","2159-662X"],"issn-type":[{"value":"0161-5505","type":"print"},{"value":"2159-662X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,8,7]]}}}