{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,7]],"date-time":"2026-09-07T21:49:03Z","timestamp":1788817743114,"version":"build-2803163510"},"reference-count":30,"publisher":"Society of Nuclear Medicine","issue":"10","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Nucl Med"],"accepted":{"date-parts":[[2025,7,28]]},"published-print":{"date-parts":[[2025,10]]},"DOI":"10.2967\/jnumed.125.270186","type":"journal-article","created":{"date-parts":[[2025,8,21]],"date-time":"2025-08-21T14:15:21Z","timestamp":1755785721000},"page":"1612-1621","source":"Crossref","is-referenced-by-count":6,"title":["Efficacy and Safety of [<sup>177<\/sup>Lu]Lu-DOTAGA.Glu.(FAPi)<sub>2<\/sub> Therapy in Patients with Sarcoma"],"prefix":"10.2967","volume":"66","author":[{"given":"Sanjana","family":"Ballal","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammad","family":"Sakir","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kunal R.","family":"Chandekar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sameer","family":"Rastogi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Madhav P.","family":"Yadav","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frank","family":"Roesch","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Madhavi","family":"Tripathi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcel","family":"Martin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chandrasekhar","family":"Bal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1602","published-online":{"date-parts":[[2025,8,21]]},"reference":[{"key":"2025100106250830000_66.10.1612.1","unstructured":"Fletcher CD Hogendoorn PC Mertens F . World Health Organization Classification of Tumours of Soft Tissue and Bone. 4th ed. International Agency for Research on Cancer Press; 2013:1\u2013467."},{"key":"2025100106250830000_66.10.1612.2","doi-asserted-by":"crossref","unstructured":"Fein Levy CW . Rhabdomyosarcoma and other soft tissue sarcomas. In: Lanzkowsky P , ed. Lanzkowsky\u2019s Manual of Pediatric Hematology and Oncology. Elsevier; 2016:505\u2013523.","DOI":"10.1016\/B978-0-12-801368-7.00026-0"},{"key":"2025100106250830000_66.10.1612.3","unstructured":"Surveillance, Epidemiology and End Results program. National Cancer Institute website. https:\/\/seer.cancer.gov\/statfacts\/. Accessed August 6, 2025."},{"key":"2025100106250830000_66.10.1612.4","doi-asserted-by":"publisher","DOI":"10.1038\/s41571-021-00546-5"},{"key":"2025100106250830000_66.10.1612.5","doi-asserted-by":"crossref","first-page":"699","DOI":"10.3892\/ol.2014.1788","article-title":"Impact of fibroblast activation protein on osteosarcoma cell lines in\u00a0vitro","volume":"7","author":"Ding","year":"2014","journal-title":"Oncol Lett."},{"key":"2025100106250830000_66.10.1612.6","doi-asserted-by":"crossref","first-page":"1412","DOI":"10.2967\/jnumed.118.214361","article-title":"Fibroblast-activating protein: targeting the roots of the tumor microenvironment","volume":"59","author":"Siveke","year":"2018","journal-title":"J Nucl Med"},{"key":"2025100106250830000_66.10.1612.7","doi-asserted-by":"publisher","DOI":"10.1002\/jso.23368"},{"key":"2025100106250830000_66.10.1612.8","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.85.9.3110"},{"key":"2025100106250830000_66.10.1612.9","doi-asserted-by":"publisher","DOI":"10.1038\/nrc.2016.73"},{"key":"2025100106250830000_66.10.1612.10","doi-asserted-by":"publisher","DOI":"10.1038\/s41568-019-0238-1"},{"key":"2025100106250830000_66.10.1612.11","doi-asserted-by":"publisher","DOI":"10.1038\/s41573-018-0004-1"},{"key":"2025100106250830000_66.10.1612.12","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-319-78127-3_6"},{"key":"2025100106250830000_66.10.1612.13","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2559.2009.03399.x"},{"key":"2025100106250830000_66.10.1612.14","doi-asserted-by":"crossref","first-page":"2480493","DOI":"10.1155\/2023\/2480493","article-title":"Fibroblast activation protein expression in sarcomas","volume":"2023","author":"Crane","year":"2023","journal-title":"Sarcoma."},{"key":"2025100106250830000_66.10.1612.15","doi-asserted-by":"publisher","DOI":"10.2967\/jnumed.121.262096"},{"key":"2025100106250830000_66.10.1612.16","doi-asserted-by":"publisher","DOI":"10.2967\/jnumed.123.267248"},{"key":"2025100106250830000_66.10.1612.17","doi-asserted-by":"crossref","first-page":"942","DOI":"10.1007\/s00259-020-04990-w","article-title":"A theranostic approach of [68Ga]Ga-DOTA.SA.FAPi PET\/CT-guided [177Lu]Lu-DOTA.SA.FAPi radionuclide therapy in an end-stage breast cancer patient: new frontier in targeted radionuclide therapy","volume":"48","author":"Ballal","year":"2021","journal-title":"Eur J Nucl Med Mol Imaging."},{"key":"2025100106250830000_66.10.1612.18","doi-asserted-by":"crossref","first-page":"1212","DOI":"10.3390\/ph14121212","article-title":"First-in-human results on the biodistribution, pharmacokinetics, and dosimetry of [177Lu]Lu-DOTA.SA.FAPi and [177Lu]Lu-DOTAGA.(SA.FAPi)2","volume":"14","author":"Ballal","year":"2021","journal-title":"Pharmaceuticals (Basel)."},{"key":"2025100106250830000_66.10.1612.19","doi-asserted-by":"crossref","first-page":"1889","DOI":"10.3390\/cancers15061889","article-title":"Novel generation of FAP inhibitor-based homodimers for improved application in radiotheranostics","volume":"15","author":"Martin","year":"2023","journal-title":"Cancers (Basel)."},{"key":"2025100106250830000_66.10.1612.20","first-page":"65","article-title":"Novel fibroblast activation protein inhibitor-based targeted theranostics for radioiodine-refractory differentiated thyroid cancer patients: a pilot study","volume":"32","author":"Ballal","year":"2022","journal-title":"Thyroid."},{"key":"2025100106250830000_66.10.1612.21","doi-asserted-by":"crossref","first-page":"805","DOI":"10.1007\/s00259-023-06482-z","article-title":"Therapeutic potential of [177Lu]Lu-DOTAGA-FAPi dimers in metastatic breast cancer patients with limited treatment options: efficacy and safety assessment","volume":"51","author":"Yadav","year":"2024","journal-title":"Eur J Nucl Med Mol Imaging."},{"key":"2025100106250830000_66.10.1612.22","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1007\/s13139-023-00814-5","article-title":"[177Lu]Lu-DOTAGA.Glu.(FAPi)2 radionuclide therapy: a new treatment option for patients with glioblastoma multiforme","volume":"58","author":"Ballal","year":"2024","journal-title":"Nucl Med Mol Imaging."},{"key":"2025100106250830000_66.10.1612.23","doi-asserted-by":"publisher","DOI":"10.2967\/jnumed.121.262468"},{"key":"2025100106250830000_66.10.1612.24","doi-asserted-by":"crossref","first-page":"4346","DOI":"10.1158\/1078-0432.CCR-22-1432","article-title":"Safety and efficacy of 90Y-FAPI-46 radioligand therapy in patients with advanced sarcoma and other cancer entities","volume":"28","author":"Fendler","year":"2022","journal-title":"Clin Cancer Res."},{"key":"2025100106250830000_66.10.1612.25","doi-asserted-by":"publisher","DOI":"10.2967\/jnumed.120.259192"},{"key":"2025100106250830000_66.10.1612.26","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1007\/s00259-024-06795-7","article-title":"Feasibility and therapeutic potential of [177Lu]Lu-FAPI-2286 in patients with advanced metastatic sarcoma","volume":"52","author":"Banihashemian","year":"2024","journal-title":"Eur J Nucl Med Mol Imaging."},{"key":"2025100106250830000_66.10.1612.27","doi-asserted-by":"publisher","DOI":"10.2967\/jnumed.124.268386"},{"key":"2025100106250830000_66.10.1612.28","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejca.2008.10.026"},{"key":"2025100106250830000_66.10.1612.29","doi-asserted-by":"crossref","first-page":"576","DOI":"10.1148\/radiol.2016142043","article-title":"Practical PERCIST: a simplified guide to PET Response Criteria in Solid Tumors 1.0","volume":"280","author":"O","year":"2016","journal-title":"Radiology."},{"key":"2025100106250830000_66.10.1612.30","doi-asserted-by":"crossref","first-page":"4026","DOI":"10.1007\/s00259-024-06809-4","article-title":"Evaluating [225Ac]Ac-FAPI-46 for the treatment of soft-tissue sarcoma in mice","volume":"51","author":"Taddio","year":"2024","journal-title":"Eur J Nucl Med Mol Imaging."}],"container-title":["Journal of Nuclear Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.2967\/jnumed.125.270186","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T13:25:41Z","timestamp":1759325141000},"score":1,"resource":{"primary":{"URL":"http:\/\/jnm.snmjournals.org\/lookup\/doi\/10.2967\/jnumed.125.270186"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,8,21]]},"references-count":30,"journal-issue":{"issue":"10","published-online":{"date-parts":[[2025,10,1]]},"published-print":{"date-parts":[[2025,10]]}},"alternative-id":["10.2967\/jnumed.125.270186"],"URL":"https:\/\/doi.org\/10.2967\/jnumed.125.270186","relation":{},"ISSN":["0161-5505","2159-662X"],"issn-type":[{"value":"0161-5505","type":"print"},{"value":"2159-662X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,8,21]]}}}