{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,2]],"date-time":"2026-03-02T14:38:14Z","timestamp":1772462294886,"version":"3.50.1"},"reference-count":45,"publisher":"Society of Nuclear Medicine","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Nucl Med"],"accepted":{"date-parts":[[2025,12,2]]},"published-print":{"date-parts":[[2026,3]]},"DOI":"10.2967\/jnumed.125.270594","type":"journal-article","created":{"date-parts":[[2025,12,30]],"date-time":"2025-12-30T16:16:18Z","timestamp":1767111378000},"page":"410-415","source":"Crossref","is-referenced-by-count":0,"title":["Tetraspanin-8 as a Tumor-Selective Immuno-PET Target in Hepatocellular Carcinoma"],"prefix":"10.2967","volume":"67","author":[{"given":"Julia","family":"Sheehan-Klenk","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hima","family":"Makala","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joon-Yong","family":"Chung","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Woonghee","family":"Lee","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kwamena E.","family":"Baidoo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Divya","family":"Nambiar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nada","family":"Alani","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stephen M.","family":"Hewitt","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuki","family":"Ueda","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Satoshi","family":"Omiya","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Freddy E.","family":"Escorcia","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1602","published-online":{"date-parts":[[2025,12,30]]},"reference":[{"key":"2026030205300702000_67.3.410.1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21660"},{"key":"2026030205300702000_67.3.410.2","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.14132361"},{"key":"2026030205300702000_67.3.410.3","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.32723"},{"key":"2026030205300702000_67.3.410.4","doi-asserted-by":"publisher","DOI":"10.1002\/hep.31288"},{"key":"2026030205300702000_67.3.410.5","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2019.07.060"},{"key":"2026030205300702000_67.3.410.6","first-page":"172","article-title":"Hepatocellular carcinoma incidence and mortality in the USA by sex, age, and race: a nationwide analysis of two decades","volume":"12","author":"Abboud","year":"2024","journal-title":"J Clin Transl Hepatol."},{"key":"2026030205300702000_67.3.410.7","doi-asserted-by":"publisher","DOI":"10.1067\/j.cpradiol.2023.10.007"},{"key":"2026030205300702000_67.3.410.8","unstructured":"Cancer stat facts: liver and intrahepatic bile duct cancer. National Cancer Institute: Surveillance, Epidemiology, and End Results Program website. https:\/\/seer.cancer.gov\/statfacts\/html\/livibd.html. Updated 2025. Accessed August 17, 2025."},{"key":"2026030205300702000_67.3.410.9","doi-asserted-by":"publisher","DOI":"10.1102\/1470-7330.2012.0044"},{"key":"2026030205300702000_67.3.410.10","doi-asserted-by":"crossref","first-page":"544","DOI":"10.2214\/AJR.16.16414","article-title":"MRI of small hepatocellular carcinoma: typical features are less frequent below a size cutoff of 1.5 cm","volume":"208","author":"Choi","year":"2017","journal-title":"AJR."},{"key":"2026030205300702000_67.3.410.11","doi-asserted-by":"publisher","DOI":"10.4103\/0256-4947.75771"},{"key":"2026030205300702000_67.3.410.12","doi-asserted-by":"crossref","first-page":"1289","DOI":"10.3748\/wjg.v25.i11.1289","article-title":"Emerging role of 18F-fluorodeoxyglucose positron emission tomography for guiding management of hepatocellular carcinoma","volume":"25","author":"Lee","year":"2019","journal-title":"World J Gastroenterol."},{"key":"2026030205300702000_67.3.410.13","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1186\/s40644-023-00626-y","article-title":"Head-to-head comparison of 18F-FAPI and 18F-FDG PET\/CT in staging and therapeutic management of hepatocellular carcinoma","volume":"23","author":"Zhang","year":"2023","journal-title":"Cancer Imaging."},{"key":"2026030205300702000_67.3.410.14","doi-asserted-by":"crossref","first-page":"e6780","DOI":"10.1002\/cam4.6780","article-title":"Establishing a robust radioligand therapy program: a practical approach for North American centers","volume":"13","author":"Mittra","year":"2024","journal-title":"Cancer Med."},{"key":"2026030205300702000_67.3.410.15","doi-asserted-by":"crossref","first-page":"916693","DOI":"10.3389\/fmed.2022.916693","article-title":"ImmunoPET: antibody-based PET imaging in solid tumors","volume":"9","author":"Manafi-Farid","year":"2022","journal-title":"Front Med (Lausanne)."},{"key":"2026030205300702000_67.3.410.16","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1607427"},{"key":"2026030205300702000_67.3.410.17","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2107322"},{"key":"2026030205300702000_67.3.410.18","doi-asserted-by":"publisher","DOI":"10.2967\/jnumed.122.265171"},{"key":"2026030205300702000_67.3.410.19","doi-asserted-by":"publisher","DOI":"10.2967\/jnumed.121.262562"},{"key":"2026030205300702000_67.3.410.20","doi-asserted-by":"publisher","DOI":"10.2967\/jnumed.123.266766"},{"key":"2026030205300702000_67.3.410.21","doi-asserted-by":"crossref","first-page":"4","DOI":"10.3390\/molecules26010004","article-title":"Glypican-3-targeted alpha particle therapy for hepatocellular carcinoma","volume":"26","author":"Bell","year":"2020","journal-title":"Molecules."},{"key":"2026030205300702000_67.3.410.22","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1186\/s13550-018-0374-8","article-title":"I-124 codrituzumab imaging and biodistribution in patients with hepatocellular carcinoma","volume":"8","author":"Carrasquillo","year":"2018","journal-title":"EJNMMI Res."},{"key":"2026030205300702000_67.3.410.23","doi-asserted-by":"publisher","DOI":"10.1016\/j.it.2003.09.011"},{"key":"2026030205300702000_67.3.410.24","doi-asserted-by":"publisher","DOI":"10.1016\/j.tcb.2023.09.003"},{"key":"2026030205300702000_67.3.410.25","doi-asserted-by":"publisher","DOI":"10.1016\/j.tcb.2009.06.004"},{"key":"2026030205300702000_67.3.410.26","doi-asserted-by":"crossref","first-page":"9594","DOI":"10.12659\/MSM.919749","article-title":"A positive tetraspanin 8 (TSPAN8)\/beta-catenin regulatory loop enhances the stemness of colorectal cancer cells","volume":"25","author":"Zhan","year":"2019","journal-title":"Med Sci Monit."},{"key":"2026030205300702000_67.3.410.27","doi-asserted-by":"crossref","first-page":"4884","DOI":"10.1038\/s41388-021-01864-9","article-title":"SOX9 is a critical regulator of TSPAN8-mediated metastasis in pancreatic cancer","volume":"40","author":"Li","year":"2021","journal-title":"Oncogene."},{"key":"2026030205300702000_67.3.410.28","doi-asserted-by":"crossref","first-page":"193","DOI":"10.3390\/cells13020193","article-title":"Molecular regulation and oncogenic functions of TSPAN8","volume":"13","author":"Yang","year":"2024","journal-title":"Cells."},{"key":"2026030205300702000_67.3.410.29","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.9769"},{"key":"2026030205300702000_67.3.410.30","first-page":"638","article-title":"Tspan8 Is highly expressed in clear cell renal cell carcinoma and indicates poor prognosis","volume":"50","author":"Tang","year":"2020","journal-title":"Ann Clin Lab Sci."},{"key":"2026030205300702000_67.3.410.31","doi-asserted-by":"publisher","DOI":"10.1016\/S0168-8278(01)00183-0"},{"key":"2026030205300702000_67.3.410.32","doi-asserted-by":"crossref","first-page":"22034","DOI":"10.18632\/oncotarget.15787","article-title":"Tetraspanin 8 (TSPAN 8) as a potential target for radio-immunotherapy of colorectal cancer","volume":"8","author":"Maisonial-Besset","year":"2017","journal-title":"Oncotarget."},{"key":"2026030205300702000_67.3.410.33","doi-asserted-by":"publisher","DOI":"10.1038\/nprot.2010.13"},{"key":"2026030205300702000_67.3.410.34","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2017.05.046"},{"key":"2026030205300702000_67.3.410.35","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1217868110"},{"key":"2026030205300702000_67.3.410.36","doi-asserted-by":"publisher","DOI":"10.2967\/jnumed.125.270167"},{"key":"2026030205300702000_67.3.410.37","doi-asserted-by":"crossref","first-page":"S180","DOI":"10.1016\/j.ijrobp.2020.07.966","article-title":"ImmunoPET as stoichiometric sensor for glypican-3 in models of hepatocellular carcinoma","volume":"108","author":"Kelada","year":"2020","journal-title":"Int J Radiat Oncol Biol Phys."},{"key":"2026030205300702000_67.3.410.38","doi-asserted-by":"crossref","first-page":"708","DOI":"10.3389\/fonc.2019.00708","article-title":"The role of glypican-3 in regulating Wnt, YAP, and hedgehog in liver cancer","volume":"9","author":"Kolluri","year":"2019","journal-title":"Front Oncol."},{"key":"2026030205300702000_67.3.410.39","doi-asserted-by":"crossref","first-page":"3348","DOI":"10.62347\/TTNY4279","article-title":"Glypican-3 deficiency in liver cancer upregulates MAPK\/ERK pathway but decreases cell proliferation","volume":"14","author":"Chung","year":"2024","journal-title":"Am J Cancer Res."},{"key":"2026030205300702000_67.3.410.40","doi-asserted-by":"publisher","DOI":"10.1186\/s13578-022-00887-3"},{"key":"2026030205300702000_67.3.410.41","doi-asserted-by":"crossref","first-page":"753833","DOI":"10.3389\/fphys.2021.753833","article-title":"The contribution of liver sinusoidal endothelial cells to clearance of therapeutic antibody","volume":"12","author":"James","year":"2021","journal-title":"Front Physiol."},{"key":"2026030205300702000_67.3.410.42","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-17-1958"},{"key":"2026030205300702000_67.3.410.43","doi-asserted-by":"publisher","DOI":"10.2967\/jnumed.118.223636"},{"key":"2026030205300702000_67.3.410.44","doi-asserted-by":"publisher","DOI":"10.1016\/j.nucmedbio.2010.12.011"},{"key":"2026030205300702000_67.3.410.45","doi-asserted-by":"crossref","first-page":"360","DOI":"10.1016\/j.nucmedbio.2014.11.005","article-title":"The impact of weakly bound 89Zr on preclinical studies: non-specific accumulation in solid tumors and aspergillus infection","volume":"42","author":"Severin","year":"2015","journal-title":"Nucl Med Biol."}],"container-title":["Journal of Nuclear Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.2967\/jnumed.125.270594","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,2]],"date-time":"2026-03-02T13:31:21Z","timestamp":1772458281000},"score":1,"resource":{"primary":{"URL":"http:\/\/jnm.snmjournals.org\/lookup\/doi\/10.2967\/jnumed.125.270594"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,12,30]]},"references-count":45,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2026,3,2]]},"published-print":{"date-parts":[[2026,3]]}},"alternative-id":["10.2967\/jnumed.125.270594"],"URL":"https:\/\/doi.org\/10.2967\/jnumed.125.270594","relation":{},"ISSN":["0161-5505","2159-662X"],"issn-type":[{"value":"0161-5505","type":"print"},{"value":"2159-662X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,12,30]]}}}