{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,28]],"date-time":"2026-07-28T21:00:07Z","timestamp":1785272407155,"version":"3.55.0"},"reference-count":36,"publisher":"Society of Nuclear Medicine","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Nucl Med"],"accepted":{"date-parts":[[2025,10,2]]},"published-print":{"date-parts":[[2026,2]]},"DOI":"10.2967\/jnumed.125.270660","type":"journal-article","created":{"date-parts":[[2025,11,13]],"date-time":"2025-11-13T16:10:15Z","timestamp":1763050215000},"page":"297-303","source":"Crossref","is-referenced-by-count":1,"title":["In Vivo PET Imaging of [\n                    <sup>18<\/sup>\n                    F]CHDI-385, a Radioligand for Mutant Huntingtin Aggregates in a Mouse Model of Huntington Disease"],"prefix":"10.2967","volume":"67","author":[{"given":"Franziska","family":"Zajicek","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Filipe","family":"Elvas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alan","family":"Miranda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jordy","family":"Akkermans","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeroen","family":"Verhaeghe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Celia","family":"Dominguez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert","family":"Doot","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vinod","family":"Khetarpal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonathan","family":"Bard","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Longbin","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steven","family":"Staelens","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniele","family":"Bertoglio","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1602","published-online":{"date-parts":[[2025,11,13]]},"reference":[{"key":"2026020205350906000_67.2.297.1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2016.02.003"},{"key":"2026020205350906000_67.2.297.2","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(93)90585-E"},{"key":"2026020205350906000_67.2.297.3","doi-asserted-by":"publisher","DOI":"10.1111\/ene.13413"},{"key":"2026020205350906000_67.2.297.4","doi-asserted-by":"publisher","DOI":"10.1007\/7854_2014_354"},{"key":"2026020205350906000_67.2.297.5","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(22)00121-1"},{"key":"2026020205350906000_67.2.297.6","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0189891"},{"key":"2026020205350906000_67.2.297.7","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0096854"},{"key":"2026020205350906000_67.2.297.8","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0213521"},{"key":"2026020205350906000_67.2.297.9","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jmedchem.1c00667"},{"key":"2026020205350906000_67.2.297.10","doi-asserted-by":"publisher","DOI":"10.1007\/s00259-021-05578-8"},{"key":"2026020205350906000_67.2.297.11","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jmedchem.0c00955"},{"key":"2026020205350906000_67.2.297.12","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-021-97334-z"},{"key":"2026020205350906000_67.2.297.13","doi-asserted-by":"crossref","first-page":"eabm3682","DOI":"10.1126\/scitranslmed.abm3682","article-title":"Development of a ligand for in vivo imaging of mutant huntingtin in Huntingtons disease","volume":"14","author":"Bertoglio","year":"2022","journal-title":"Sci Transl Med."},{"key":"2026020205350906000_67.2.297.14","doi-asserted-by":"publisher","DOI":"10.2967\/jnumed.123.265569"},{"key":"2026020205350906000_67.2.297.15","doi-asserted-by":"crossref","first-page":"641","DOI":"10.1021\/acs.jmedchem.2c01585","article-title":"Design and evaluation of [18F]CHDI-650 as a positron emission tomography ligand to image mutant huntingtin aggregates","volume":"66","author":"Liu","year":"2023","journal-title":"J Med Chem."},{"key":"2026020205350906000_67.2.297.16","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1007\/s00259-024-06880-x","article-title":"Preclinical evaluation of the novel [18F]CHDI-650 PET ligand for non-invasive quantification of mutant huntingtin aggregates in Huntingtons disease","volume":"52","author":"Zajicek","year":"2024","journal-title":"Eur J Nucl Med Mol Imaging."},{"key":"2026020205350906000_67.2.297.17","doi-asserted-by":"crossref","unstructured":"Zajicek F Everix L Van Eetveldt A . Preclinical evaluation of [11C]CHDI-009R for quantification of mutant huntingtin aggregates. https:\/\/www.biorxiv.org\/content\/10.1101\/2025.06.17.660088v2. Accessed October 20, 2025.","DOI":"10.21203\/rs.3.rs-6820127\/v1"},{"key":"2026020205350906000_67.2.297.18","doi-asserted-by":"crossref","first-page":"14818","DOI":"10.1021\/acs.jmedchem.5c01005","article-title":"Isoindolinone-based PET tracers for imaging mutant huntingtin aggregates","volume":"68","author":"Liu","year":"2025","journal-title":"J Med Chem."},{"key":"2026020205350906000_67.2.297.19","unstructured":"iMagemHTT: FIH evaluation of novel mutant huntingtin PET radioligands 11C CHDI-00485180-R and 11C CHDI-00485626. National Library of Medicine website. https:\/\/ClinicalTrials.gov\/show\/NCT03810898. Accessed October 20, 2025."},{"key":"2026020205350906000_67.2.297.20","doi-asserted-by":"publisher","DOI":"10.1007\/s00259-022-05945-z"},{"key":"2026020205350906000_67.2.297.21","doi-asserted-by":"crossref","unstructured":"Delva A Koole M Serdons K . PET imaging with [11C]CHDI-00485180-R, designed as radioligand for aggregated mutant huntingtin, in people with Huntingtons disease. Eur J Nucl Med Mol Imaging. June 18, 2025 [Epub ahead of print].","DOI":"10.1007\/s00259-025-07394-w"},{"key":"2026020205350906000_67.2.297.22","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0049838"},{"key":"2026020205350906000_67.2.297.23","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0050717"},{"key":"2026020205350906000_67.2.297.24","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0069782"},{"key":"2026020205350906000_67.2.297.25","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1186\/s41181-019-0079-y","article-title":"Fast and efficient copper-mediated 18F-fluorination of arylstannanes, aryl boronic acids, and aryl boronic esters without azeotropic drying","volume":"4","author":"Lahdenpohja","year":"2019","journal-title":"EJNMMI Radiopharm Chem."},{"key":"2026020205350906000_67.2.297.26","doi-asserted-by":"publisher","DOI":"10.1177\/0271678X19864081"},{"key":"2026020205350906000_67.2.297.27","doi-asserted-by":"crossref","first-page":"045001","DOI":"10.1088\/2057-1976\/ab8c13","article-title":"Validation of a spatially variant resolution model for small animal brain PET studies","volume":"6","author":"Miranda","year":"2020","journal-title":"Biomed Phys Eng Express."},{"key":"2026020205350906000_67.2.297.28","doi-asserted-by":"publisher","DOI":"10.1093\/bja\/aef182"},{"key":"2026020205350906000_67.2.297.29","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0206613"},{"key":"2026020205350906000_67.2.297.30","doi-asserted-by":"publisher","DOI":"10.2967\/jnumed.108.057174"},{"key":"2026020205350906000_67.2.297.31","doi-asserted-by":"crossref","first-page":"551","DOI":"10.1146\/annurev-bioeng-062117-121056","article-title":"Human positron emission tomography neuroimaging","volume":"21","author":"Hooker","year":"2019","journal-title":"Annu Rev Biomed Eng."},{"key":"2026020205350906000_67.2.297.32","first-page":"1836","article-title":"SUV: standard uptake or silly useless value","volume":"36","author":"Keyes","year":"1995","journal-title":"J Nucl Med."},{"key":"2026020205350906000_67.2.297.33","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1007\/s40336-014-0067-x","article-title":"Deriving physiological information from PET images: from SUV to compartmental modelling","volume":"2","author":"Bertoldo","year":"2014","journal-title":"Clin Transl Imaging."},{"key":"2026020205350906000_67.2.297.34","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awae063"},{"key":"2026020205350906000_67.2.297.35","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awz115"},{"key":"2026020205350906000_67.2.297.36","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2019.01.039"}],"container-title":["Journal of Nuclear Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.2967\/jnumed.125.270660","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,28]],"date-time":"2026-07-28T20:19:07Z","timestamp":1785269947000},"score":1,"resource":{"primary":{"URL":"http:\/\/jnm.snmjournals.org\/lookup\/doi\/10.2967\/jnumed.125.270660"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,11,13]]},"references-count":36,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2026,2,2]]},"published-print":{"date-parts":[[2026,2]]}},"alternative-id":["10.2967\/jnumed.125.270660"],"URL":"https:\/\/doi.org\/10.2967\/jnumed.125.270660","relation":{},"ISSN":["0161-5505","2159-662X"],"issn-type":[{"value":"0161-5505","type":"print"},{"value":"2159-662X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,11,13]]}}}