{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T15:54:56Z","timestamp":1791474896193,"version":"4.3.4"},"reference-count":47,"publisher":"Society of Nuclear Medicine","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Nucl Med"],"accepted":{"date-parts":[[2026,9,15]]},"DOI":"10.2967\/jnumed.126.272755","type":"journal-article","created":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T15:20:26Z","timestamp":1791472826000},"page":"jnumed.126.272755","source":"Crossref","is-referenced-by-count":0,"title":["Enzyme-Responsive Linkers Enable In\u00a0Vivo Clearance of Circulating Radioimmunoconjugates"],"prefix":"10.2967","author":[{"given":"Swarbhanu","family":"Sarkar","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonathan M.","family":"Pham","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andres","family":"Fernandez del Castillo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lily H.","family":"Min","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Estela","family":"Noguera-Ortega","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephen J.","family":"Schuster","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark A.","family":"Sellmyer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1602","published-online":{"date-parts":[[2026,10,8]]},"reference":[{"key":"2026100808202075000_jnumed.126.272755v1.1","doi-asserted-by":"publisher","DOI":"10.1038\/nrc3925"},{"key":"2026100808202075000_jnumed.126.272755v1.2","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1016\/j.biomaterials.2018.06.021","article-title":"Pretargeting in nuclear imaging and radionuclide therapy: improving efficacy of theranostics and nanomedicines","volume":"179","author":"St\u00e9en","year":"2018","journal-title":"Biomaterials."},{"key":"2026100808202075000_jnumed.126.272755v1.3","doi-asserted-by":"publisher","DOI":"10.2967\/jnumed.117.189944"},{"key":"2026100808202075000_jnumed.126.272755v1.4","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1021\/acs.bioconjchem.9b00761","article-title":"Antibody pretargeting based on bioorthogonal click chemistry for cancer imaging and targeted radionuclide therapy","volume":"31","author":"Rondon","year":"2020","journal-title":"Bioconjug Chem."},{"key":"2026100808202075000_jnumed.126.272755v1.5","first-page":"140","article-title":"Pretargeted radioimmunotherapy with a single-chain antibody\/streptavidin construct and radiolabeled DOTA-biotin: strategies for reduction of the renal dose","volume":"47","author":"F\u00f6rster","year":"2006","journal-title":"J Nucl Med."},{"key":"2026100808202075000_jnumed.126.272755v1.6","doi-asserted-by":"publisher","DOI":"10.1007\/s00259-002-1090-0"},{"key":"2026100808202075000_jnumed.126.272755v1.7","doi-asserted-by":"publisher","DOI":"10.1016\/S1050-3862(99)00044-3"},{"key":"2026100808202075000_jnumed.126.272755v1.8","doi-asserted-by":"publisher","DOI":"10.1021\/bc970053e"},{"key":"2026100808202075000_jnumed.126.272755v1.9","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1186\/s13550-017-0344-6","article-title":"Pretargeting of internalizing trastuzumab and cetuximab with a 18F-tetrazine tracer in xenograft models","volume":"7","author":"Kein\u00e4nen","year":"2017","journal-title":"EJNMMI Res."},{"key":"2026100808202075000_jnumed.126.272755v1.10","doi-asserted-by":"crossref","first-page":"7600","DOI":"10.1021\/acs.molpharmaceut.5c01180","article-title":"Pretargeted immuno-PET enables monoclonal antibody imaging beyond the blood-brain barrier","volume":"22","author":"Gustavsson","year":"2025","journal-title":"Mol Pharm."},{"key":"2026100808202075000_jnumed.126.272755v1.11","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1016\/j.cbpa.2014.07.023","article-title":"Pretargeted imaging using bioorthogonal chemistry in mice","volume":"21","author":"Rossin","year":"2014","journal-title":"Curr Opin Chem Biol."},{"key":"2026100808202075000_jnumed.126.272755v1.12","doi-asserted-by":"publisher","DOI":"10.2967\/jnumed.112.115840"},{"key":"2026100808202075000_jnumed.126.272755v1.13","doi-asserted-by":"publisher","DOI":"10.1021\/acs.bioconjchem.5b00504"},{"key":"2026100808202075000_jnumed.126.272755v1.14","doi-asserted-by":"publisher","DOI":"10.7150\/thno.84865"},{"key":"2026100808202075000_jnumed.126.272755v1.15","doi-asserted-by":"crossref","first-page":"1543","DOI":"10.1021\/acs.bioconjchem.4c00337","article-title":"Scission-enhanced molecular imaging (SEMI)","volume":"35","author":"Quintana","year":"2024","journal-title":"Bioconjug Chem."},{"key":"2026100808202075000_jnumed.126.272755v1.16","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1186\/s13550-025-01213-x","article-title":"A biorthogonal chemistry approach for high-contrast antibody imaging of lymphoma at early time points","volume":"15","author":"Sarkar","year":"2025","journal-title":"EJNMMI Res."},{"key":"2026100808202075000_jnumed.126.272755v1.17","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1002\/ps.2780180304","article-title":"Acaricidal 1,2,4,5-tetrazines","volume":"18","author":"Brooker","year":"1987","journal-title":"Pestic Sci."},{"key":"2026100808202075000_jnumed.126.272755v1.18","doi-asserted-by":"crossref","first-page":"2853","DOI":"10.1021\/jacsau.3c00843","article-title":"Enabling universal access to rapid and stable tetrazine bioorthogonal probes through triazolyl-tetrazine formation","volume":"4","author":"Yang","year":"2024","journal-title":"JACS Au."},{"key":"2026100808202075000_jnumed.126.272755v1.19","first-page":"e06817","article-title":"Peer review of the pesticide risk assessment of the active substance clofentezine","volume":"19","author":"Alvarez","year":"2021","journal-title":"EFSA Journal."},{"key":"2026100808202075000_jnumed.126.272755v1.20","doi-asserted-by":"publisher","DOI":"10.1016\/j.cbpa.2013.07.031"},{"key":"2026100808202075000_jnumed.126.272755v1.21","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.2c01056"},{"key":"2026100808202075000_jnumed.126.272755v1.22","doi-asserted-by":"publisher","DOI":"10.1039\/c7cs00184c"},{"key":"2026100808202075000_jnumed.126.272755v1.23","doi-asserted-by":"crossref","unstructured":"Hermanson GT . Bioconjugate Techniques. 3rd ed. Academic Press; 2013:387\u2013394.","DOI":"10.1016\/B978-0-12-382239-0.00009-1"},{"key":"2026100808202075000_jnumed.126.272755v1.24","unstructured":"Gspt1-degrading compounds, anti-Cd33 antibodies and antibody-drug conjugates and uses thereof. World Intellectual Property Organization website. https:\/\/patentscope.wipo.int\/search\/en\/detail.jsf?docId=WO2025085489. Accessed September 23, 2026."},{"key":"2026100808202075000_jnumed.126.272755v1.25","doi-asserted-by":"crossref","first-page":"538","DOI":"10.1021\/acs.bioconjchem.8b00028","article-title":"Bioorthogonal masking of circulating antibody\u2013TCO groups using tetrazine-functionalized dextran polymers","volume":"29","author":"Meyer","year":"2018","journal-title":"Bioconjug Chem."},{"key":"2026100808202075000_jnumed.126.272755v1.26","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1021\/acschembio.0c00935","article-title":"A chemical approach for programmable protein outputs based on engineered cell interactions","volume":"16","author":"Jacome","year":"2021","journal-title":"ACS Chem Biol."},{"key":"2026100808202075000_jnumed.126.272755v1.27","doi-asserted-by":"publisher","DOI":"10.1021\/bc0600214"},{"key":"2026100808202075000_jnumed.126.272755v1.28","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1021\/ml100039h","article-title":"Expanded utility of the \u03b2-glucuronide linker: ADCs that deliver phenolic cytotoxic agents","volume":"1","author":"Jeffrey","year":"2010","journal-title":"ACS Med Chem Lett."},{"key":"2026100808202075000_jnumed.126.272755v1.29","doi-asserted-by":"crossref","first-page":"555","DOI":"10.1021\/acs.jmedchem.4c02344","article-title":"Evaluation of dynamic light scattering as an effective quality control method for aggregates in radiolabeled antibodies","volume":"68","author":"Nguyen","year":"2025","journal-title":"J Med Chem."},{"key":"2026100808202075000_jnumed.126.272755v1.30","doi-asserted-by":"crossref","first-page":"109051","DOI":"10.1016\/j.nucmedbio.2025.109051","article-title":"ImmunoPET for mesothelin positive tissues using bio-orthogonal in-vivo click chemistry","volume":"148\u2013149","author":"Pratt","year":"2025","journal-title":"Nucl Med Biol."},{"key":"2026100808202075000_jnumed.126.272755v1.31","doi-asserted-by":"crossref","first-page":"927","DOI":"10.1021\/bc025655z","article-title":"Conditionally cleavable radioimmunoconjugates: a novel approach for the release of radioisotopes from radioimmunoconjugates","volume":"14","author":"Beeson","year":"2003","journal-title":"Bioconjug Chem."},{"key":"2026100808202075000_jnumed.126.272755v1.32","doi-asserted-by":"publisher","DOI":"10.1016\/j.blre.2014.09.003"},{"key":"2026100808202075000_jnumed.126.272755v1.33","doi-asserted-by":"publisher","DOI":"10.1038\/clpt.1989.120"},{"key":"2026100808202075000_jnumed.126.272755v1.34","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.271.8.4461"},{"key":"2026100808202075000_jnumed.126.272755v1.35","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1021\/bc0602681","article-title":"Development of tissue plasminogen activator specific \u201con demand cleavable\u201d (ODC) linkers for radioimmunotherapy by screening one-bead-one-compound combinatorial peptide libraries","volume":"18","author":"Kumaresan","year":"2007","journal-title":"Bioconjug Chem."},{"key":"2026100808202075000_jnumed.126.272755v1.36","doi-asserted-by":"crossref","unstructured":"Kumaresan PR Luo J Lam KS . On-demand cleavable linkers for radioimmunotherapy. In: Bugge TH Antalis TM , eds. Proteases and Cancer: Methods and Protocols. Humana Press; 2009:191\u2013211.","DOI":"10.1007\/978-1-60327-003-8_11"},{"key":"2026100808202075000_jnumed.126.272755v1.37","doi-asserted-by":"crossref","first-page":"1313","DOI":"10.1021\/bc800024v","article-title":"Evaluation of ketone-oxime method for developing therapeutic on-demand cleavable immunoconjugates","volume":"19","author":"Kumaresan","year":"2008","journal-title":"Bioconjug Chem."},{"key":"2026100808202075000_jnumed.126.272755v1.38","doi-asserted-by":"publisher","DOI":"10.1016\/J.YMGME.2020.01.003"},{"key":"2026100808202075000_jnumed.126.272755v1.39","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/j.ymgme.2020.02.009","article-title":"Vestronidase alfa: Recombinant human \u03b2-glucuronidase as an enzyme replacement therapy for MPS VII","volume":"130","author":"Cadaoas","year":"2020","journal-title":"Mol Genet Metab."},{"key":"2026100808202075000_jnumed.126.272755v1.40","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjc.6602337"},{"key":"2026100808202075000_jnumed.126.272755v1.41","first-page":"732","article-title":"Glucarpidase (Voraxaze), a carboxypeptidase enzyme for methotrexate toxicity","volume":"38","author":"Rattu","year":"2013","journal-title":"P T."},{"key":"2026100808202075000_jnumed.126.272755v1.42","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.1996.14.7.2145"},{"key":"2026100808202075000_jnumed.126.272755v1.43","doi-asserted-by":"crossref","first-page":"403","DOI":"10.2147\/TCRM.S30135","article-title":"Glucarpidase to combat toxic levels of methotrexate in patients","volume":"8","author":"Green","year":"2012","journal-title":"Ther Clin Risk Manag."},{"key":"2026100808202075000_jnumed.126.272755v1.44","first-page":"1724","article-title":"Three new prodrugs for suicide gene therapy using carboxypeptidase G2 elicit bystander efficacy in two xenograft models","volume":"62","author":"Friedlos","year":"2002","journal-title":"Cancer Res."},{"key":"2026100808202075000_jnumed.126.272755v1.45","doi-asserted-by":"publisher","DOI":"10.1021\/jm0502182"},{"key":"2026100808202075000_jnumed.126.272755v1.46","doi-asserted-by":"publisher","DOI":"10.1038\/nrc2247"},{"key":"2026100808202075000_jnumed.126.272755v1.47","doi-asserted-by":"publisher","DOI":"10.1021\/jm020462i"}],"container-title":["Journal of Nuclear Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.2967\/jnumed.126.272755","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T15:20:30Z","timestamp":1791472830000},"score":1,"resource":{"primary":{"URL":"http:\/\/jnm.snmjournals.org\/lookup\/doi\/10.2967\/jnumed.126.272755"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,10,8]]},"references-count":47,"alternative-id":["10.2967\/jnumed.126.272755"],"URL":"https:\/\/doi.org\/10.2967\/jnumed.126.272755","relation":{},"ISSN":["0161-5505","2159-662X"],"issn-type":[{"value":"0161-5505","type":"print"},{"value":"2159-662X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,10,8]]}}}