{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T03:58:51Z","timestamp":1787025531372,"version":"build-2736575974"},"reference-count":19,"publisher":"American Mosquito Control Association","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,3]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    The Asian tiger mosquito,\n                    <jats:italic>Aedes albopictus<\/jats:italic>\n                    , is an important vector of chikungunya, dengue, yellow fever, and Zika viruses. Vector control remains an important means for the prevention and control of vector-borne diseases. The development of insecticide resistance has become a serious threat to the efficacy of insecticide-based control programs. To understand the resistance status and the underlying genetic mechanism in mosquitoes in Guangyuan City of Sichuan Province, China, we investigated the susceptibility of\n                    <jats:italic>Ae. albopictus<\/jats:italic>\n                    to four commonly used insecticides. We found that all the examined populations were susceptible to malathion and propoxur. However,\n                    <jats:italic>Ae. albopictus<\/jats:italic>\n                    populations in Guangyuan showed a possible resistance to the two tested pyrethroids (beta-cypermethrin and deltamethrin). Notably, phenotypic resistance to deltamethrin was detected in 2 of the 7 populations. The potential of resistance to pyrethroids was confirmed by the presence of knockdown resistance (\n                    <jats:italic>kdr<\/jats:italic>\n                    ) related mutations in the voltage-gated sodium channel. Four\n                    <jats:italic>kdr<\/jats:italic>\n                    mutations (V1016G, I1532T, F1534L, and F1534S) were identified to be present alone or in combination, and their distribution displayed significant spatial heterogeneity. These findings are helpful for making evidence-based mosquito control strategies and highlight the need to regularly monitor the dynamics of pyrethroid resistance in this city.\n                  <\/jats:p>","DOI":"10.2987\/23-7155","type":"journal-article","created":{"date-parts":[[2024,1,20]],"date-time":"2024-01-20T06:10:24Z","timestamp":1705731024000},"page":"20-25","source":"Crossref","is-referenced-by-count":4,"title":["Insecticide Susceptibility and KDR Mutations in Aedes albopictus Collected from Seven Districts of Guangyuan city, Northern Sichuan, China"],"prefix":"10.2987","volume":"40","author":[{"given":"QIONGYAO","family":"ZHAO","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"YONGCHAO","family":"JIA","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"XIAOQIANG","family":"LU","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"YANCHUN","family":"LIU","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"ZHONGYI","family":"YIN","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"YANFANG","family":"ZHANG","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"YU","family":"FU","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"XING","family":"LUO","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"ZICAI","family":"CHU","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"XINGHUI","family":"QIU","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1569","reference":[{"key":"i1943-6270-40-1-20-ref02","series-title":"Nucleic Acids Res","first-page":"1792","article-title":"MUSCLE: multiple sequence alignment with high accuracy and high throughput","volume":"32","author":"Edgar","year":"2004","unstructured":"Edgar\n              RC.\n            \n          \n          2004.\nMUSCLE: multiple sequence alignment with high accuracy and high throughput.\nNucleic Acids Res32:\n1792\u20131797.\nhttp:\/\/dx.doi.org\/10.1093\/nar\/gkh340"},{"key":"i1943-6270-40-1-20-ref03","series-title":"Infectious Dis Poverty","first-page":"1","article-title":"Correlation between adult pyrethroid resistance and knockdown resistance (kdr) mutations in Aedes albopictus (Diptera: Culicidae) field populations in China","volume":"7","author":"Gao","year":"2018","unstructured":"Gao\n              J,\n            \n            \n              Chen\n              H,\n            \n            \n              Shi\n              H,\n            \n            \n              Peng\n              H,\n            \n            \n              Ma\n              Y.\n            \n          \n          2018.\nCorrelation between adult pyrethroid resistance and knockdown resistance (kdr) mutations in Aedes albopictus (Diptera: Culicidae) field populations in China.\nInfectious Dis Poverty7:\n1\u20139.\nhttps:\/\/doi.org\/10.1186\/s40249-018-0471-y"},{"key":"i1943-6270-40-1-20-ref04","series-title":"Med Vet Entomol","first-page":"215","article-title":"Critical review of the vector status of Aedes albopictus","volume":"18","author":"Gratz","year":"2004","unstructured":"Gratz\n              NG.\n            \n          \n          2004.\nCritical review of the vector status of Aedes albopictus.\nMed Vet Entomol18:\n215\u2013227.\nhttps:\/\/doi.org\/10.1111\/j.0269-283X.2004.00513.x"},{"key":"i1943-6270-40-1-20-ref05","series-title":"Parasites Infect Dis","first-page":"41","article-title":"Monitoring and analysis of drug resistance of Aedes albopictus in Guangyuan in 2015","volume":"16","author":"Jia","year":"2018","unstructured":"Jia\n              Y,\n            \n            \n              Yang\n              Y,\n            \n            \n              Luo\n              X,\n            \n            \n              Zhao\n              J.\n            \n          \n          2018.\nMonitoring and analysis of drug resistance of Aedes albopictus in Guangyuan in 2015.\nParasites Infect Dis16:\n41\u201343. (\nIn Chinese)"},{"key":"i1943-6270-40-1-20-ref06","series-title":"Euro Surveill","first-page":"1700847","article-title":"First detection of a vssc allele V1016G conferring a high level of insecticide resistance in Aedes albopictus collected from Europe (Italy) and Asia (Vietnam), 2016: a new emerging threat to controlling arboviral diseases","volume":"24","author":"Kasai","year":"2019","unstructured":"Kasai\n              S,\n            \n            \n              Caputo\n              B,\n            \n            \n              Tsunoda\n              T,\n            \n            \n              Cuong\n              TC,\n            \n            \n              Maekawa\n              Y,\n            \n            \n              Lam-Phua\n              S G,\n            \n            \n              Pichler\n              V,\n            \n            \n              Itokawa\n              K,\n            \n            \n              Murota\n              K,\n            \n            \n              Komagata\n              O,\n            \n            \n              Yoshida\n              C,\n            \n            \n              Chung\n              HH,\n            \n            \n              Bellini\n              R,\n            \n            \n              Tsuda\n              Y,\n            \n            \n              Teng\n              HJ,\n            \n            \n              de Lima\n              JL,\n            \n            \n              Alves\n              LC,\n            \n            \n              Ng\n              LC,\n            \n            \n              Minakawa\n              N,\n            \n            \n              Yen\n              NT,\n            \n            \n              Phong\n              TV,\n            \n            \n              Sawabe\n              K,\n            \n            \n              Tomita\n              T.\n            \n          \n          2019.\nFirst detection of a vssc allele V1016G conferring a high level of insecticide resistance in Aedes albopictus collected from Europe (Italy) and Asia (Vietnam), 2016: a new emerging threat to controlling arboviral diseases.\nEuro Surveill24:\n1700847.\nhttps:\/\/doi.org\/10.2807\/1560-7917.ES.2019.24.5.1700847"},{"key":"i1943-6270-40-1-20-ref07","series-title":"Jpn J Infect Dis","first-page":"217","article-title":"First detection of a putative knockdown resistance gene in major mosquito vector, Aedes albopictus","volume":"64","author":"Kasai","year":"2011","unstructured":"Kasai\n              S,\n            \n            \n              Ng\n              LC,\n            \n            \n              Lam-Phua\n              SG,\n            \n            \n              Tang\n              CS,\n            \n            \n              Itokawa\n              K,\n            \n            \n              Komagata\n              O,\n            \n            \n              Kobayashi\n              M,\n      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in urban Aedes albopictus populations in southern China","volume":"11","author":"Li","year":"2018","unstructured":"Li\n              Y,\n            \n            \n              Xu\n              J,\n            \n            \n              Zhong\n              D,\n            \n            \n              Zhang\n              H,\n            \n            \n              Yang\n              W,\n            \n            \n              Zhou\n              G,\n            \n            \n              Su\n              X,\n            \n            \n              Wu\n              Y,\n            \n            \n              Wu\n              K,\n            \n            \n              Cai\n              S,\n            \n            \n              Yan\n              G,\n            \n            \n              Chen\n              X.\n            \n          \n          2018.\nEvidence for multiple-insecticide resistance in urban Aedes albopictus populations in southern China.\nParasit Vectors.\n11:\n1\u201310.\nhttps:\/\/doi.org\/10.1186\/s13071-017-2581-y"},{"key":"i1943-6270-40-1-20-ref10","series-title":"Sci Total Environ","first-page":"203","article-title":"Modeling the present and future distribution of arbovirus vectors Aedes aegypti and Aedes albopictus under climate change scenarios in Mainland China","volume":"664","author":"Liu","year":"2019","unstructured":"Liu\n              B,\n            \n            \n              Gao\n              Z,\n            \n            \n              Ma\n              J,\n            \n            \n              Jia\n              Z,\n            \n            \n              Xiao\n              J,\n            \n            \n              Haat\n              MA,\n            \n            \n              Wang\n              H.\n            \n          \n          2019.\nModeling the present and future distribution of arbovirus vectors Aedes aegypti and Aedes albopictus under climate change scenarios in Mainland China.\nSci Total Environ664203\u2013214.\nhttps:\/\/doi.org\/10.1016\/jscitotenv.2019.01.301"},{"key":"i1943-6270-40-1-20-ref11","series-title":"Chin J Vector Biol Control","first-page":"705","article-title":"Bionomic characteristics of dengue vector Aedes mosquitoes in Guangyuan of Sichuan province, China, 2018-2020","volume":"32","author":"Luo","year":"2021","unstructured":"Luo\n              X,\n            \n            \n              Liu\n              Y,\n            \n            \n              Jia\n              Y.\n            \n          \n          2021.\nBionomic characteristics of dengue vector Aedes mosquitoes in Guangyuan of Sichuan province, China, 2018-2020.\nChin J Vector Biol Control32:\n705\u2013709.\nhttps:\/\/doi.org\/10.11853\/j.issn.1003.8280.2021.06.010"},{"key":"i1943-6270-40-1-20-ref12","series-title":"PLoS One","first-page":"91","article-title":"Insecticide resistance status of United States populations of Aedes albopictus and mechanisms involved","author":"Marcombe","year":"2014","unstructured":"Marcombe\n              S,\n            \n            \n              Farajollahi\n              A,\n            \n            \n              Healy\n              SP,\n            \n            \n              Clark\n              GG,\n            \n            \n              Fonseca\n              DM.\n            \n          \n          2014.\nInsecticide resistance status of United States populations of Aedes albopictus and mechanisms involved.\nPLoS One91\u201310.\nhttps:\/\/doi.org\/10.1371\/journal.pone.0101992"},{"key":"i1943-6270-40-1-20-ref13","series-title":"PLoS Negl Trop Dis","first-page":"1","article-title":"Contemporary status of insecticide resistance in the major Aedes vectors of arboviruses infecting humans","volume":"11","author":"Moyes","year":"2017","unstructured":"Moyes\n              CL,\n            \n            \n              Vontas\n              J,\n            \n            \n              Martins\n              AJ,\n            \n            \n              Ng\n              LC,\n            \n            \n              Koou\n              SY,\n            \n            \n              Dusfour\n              I,\n            \n            \n              Raghavendra\n              K,\n            \n            \n              Pinto\n              J,\n            \n            \n              Corbel\n              V,\n            \n            \n              David\n              JP,\n            \n            \n              Weetman\n              D.\n            \n          \n          2017.\nContemporary status of insecticide resistance in the major Aedes vectors of arboviruses infecting humans.\nPLoS Negl Trop Dis11:\n1\u201320.\nhttps:\/\/doi.org\/10.1371\/journal.pntd.0005625"},{"key":"i1943-6270-40-1-20-ref14","series-title":"Insects","first-page":"79","article-title":"A novel allele specific polymerase chain reaction (AS-PCR) assay to detect the V1016G knockdown resistance mutation confirms its widespread presence in Aedes albopictus populations from Italy","volume":"12","author":"Pichler","year":"2021","unstructured":"Pichler\n              V,\n            \n            \n              Mancini\n              E,\n            \n            \n              Micocci\n              M,\n            \n            \n              Calzetta\n              M,\n            \n            \n              Arnoldi\n              D,\n            \n            \n              Rizzoli\n              A,\n            \n            \n              Lencioni\n              V,\n            \n            \n              Paoli\n              F,\n            \n            \n              Bellini\n              R,\n            \n            \n              Veronesi\n              R,\n            \n            \n              Martini\n              S,\n            \n            \n              Drago,\n              A,\n            \n            \n              De Liberato\n              C,\n            \n            \n              Ermenegildi\n              A,\n            \n            \n              Pinto\n              J,\n            \n            \n              della Torre\n              A,\n            \n            \n              Caputo\n              B.\n            \n          \n          2021.\nA novel allele specific polymerase chain reaction (AS-PCR) assay to detect the V1016G knockdown resistance mutation confirms its widespread presence in Aedes albopictus populations from Italy.\nInsects12:\n79.\nhttps:\/\/doi.org\/10.3390\/insects12010079"},{"key":"i1943-6270-40-1-20-ref15","series-title":"Insect Mol Biol","first-page":"157","article-title":"Frequencies of the pyrethroid resistance alleles of Vsscl and CYP6D1 in house flies from the eastern United States","volume":"15","author":"Rinkevich","year":"2006","unstructured":"Rinkevich\n              FD,\n            \n            \n              Zhang\n              L,\n           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region of mitochondrial DNA in humans and chimpanzees.\nMol Biol Evol10:\n512\u2013526."},{"key":"i1943-6270-40-1-20-ref17","series-title":"J Econ Entomol","first-page":"239","article-title":"A survey of insecticide resistance in Aedes albopictus (Diptera: Culicidae) during a 2014 Dengue fever outbreak in Guangzhou, China","volume":"110","author":"Wang","year":"2017","unstructured":"Wang\n              Y,\n            \n            \n              Liu\n              X,\n            \n            \n              Li\n              C,\n            \n            \n              Su\n              T,\n            \n            \n              Jin\n              J,\n            \n            \n              Guo\n              Y,\n            \n            \n              Ren\n              D,\n            \n            \n              Yang\n              Z,\n            \n            \n              Liu\n              Q,\n            \n            \n              Meng\n              F.\n            \n          \n          2017.\nA survey of insecticide resistance in Aedes albopictus (Diptera: Culicidae) during a 2014 Dengue fever outbreak in Guangzhou, China.\nJ Econ Entomol110:\n239\u2013244."},{"key":"i1943-6270-40-1-20-ref18","series-title":"Test procedures for insecticide resistance monitoring in malaria vector mosquitoes","author":"WHO [World Health Organization]","year":"2016","unstructured":"WHO [World Health Organization]\n          .\n2016.\nTest procedures for insecticide resistance monitoring in malaria vector mosquitoes,\n2nd edition.\nGeneva:\nWorld Health Organization."},{"key":"i1943-6270-40-1-20-ref19","series-title":"PLoS Negl Trop Dis","first-page":"1","article-title":"Multi-country survey revealed prevalent and novel F1534S mutation in voltage-gated sodium channel (VGSC) gene in Aedes albopictus","volume":"10","author":"Xu","year":"2016","unstructured":"Xu\n              J,\n            \n            \n              Bonizzoni\n              M,\n            \n            \n              Zhong\n              D,\n            \n            \n              Zhou\n              G,\n            \n            \n              Cai\n              S,\n            \n            \n              Li\n              Y,\n            \n            \n              Wang\n              X,\n            \n            \n              Lo\n              E,\n            \n            \n              Lee\n              R,\n            \n            \n              Sheen\n              R,\n            \n            \n              Duan\n              J,\n            \n            \n              Yan\n              G,\n            \n            \n              Chen\n              XG\n            \n          \n          2016.\nMulti-country survey revealed prevalent and novel F1534S mutation in voltage-gated sodium channel (VGSC) gene in Aedes albopictus.\nPLoS Negl Trop Dis10:\n1\u201312.\nhttps:\/\/doi.org\/10.1371\/journal.pntd.0004696"},{"key":"i1943-6270-40-1-20-ref20","series-title":"Parasit Vectors","first-page":"1","article-title":"Knockdown resistance (kdr) mutations within seventeen field populations of Aedes albopictus from Beijing China: first report of a novel V1016G mutation and evolutionary origins of kdr haplotypes","volume":"12","author":"Zhou","year":"2019","unstructured":"Zhou\n              X,\n            \n            \n              Yang\n              C,\n            \n            \n              Liu\n              N,\n            \n            \n              Li\n              M,\n            \n            \n              Tong\n              Y,\n            \n            \n              Zeng\n              X,\n            \n            \n              Qiu\n              X.\n            \n          \n          2019.\nKnockdown resistance (kdr) mutations within seventeen field populations of Aedes albopictus from Beijing China: first report of a novel V1016G mutation and evolutionary origins of kdr haplotypes.\nParasit Vectors12:\n1\u201316.\nhttps:\/\/doi.org\/10.1186\/s13071-019-3423-x"}],"container-title":["Journal of the American Mosquito Control Association"],"original-title":[],"link":[{"URL":"https:\/\/jamca.kglmeridian.com\/view\/journals\/moco\/40\/1\/article-p20.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/meridian.allenpress.com\/jamca\/article-pdf\/40\/1\/20\/3336206\/i1943-6270-40-1-20.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/jamca.kglmeridian.com\/downloadpdf\/journals\/moco\/40\/1\/article-p20.xml","content-type":"text\/html","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/jamca.kglmeridian.com\/downloadpdf\/journals\/moco\/40\/1\/article-p20.xml","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,5,15]],"date-time":"2025-05-15T20:42:07Z","timestamp":1747341727000},"score":1,"resource":{"primary":{"URL":"https:\/\/jamca.kglmeridian.com\/view\/journals\/moco\/40\/1\/article-p20.xml"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,3]]},"references-count":19,"journal-issue":{"issue":"1"},"URL":"https:\/\/doi.org\/10.2987\/23-7155","relation":{},"ISSN":["1943-6270","8756-971X"],"issn-type":[{"value":"1943-6270","type":"electronic"},{"value":"8756-971X","type":"print"}],"subject":[],"published":{"date-parts":[[2024,3]]}}}