{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,8]],"date-time":"2026-01-08T19:19:29Z","timestamp":1767899969331,"version":"3.49.0"},"reference-count":41,"publisher":"Korean Neuropsychiatric Association","issue":"11","license":[{"start":{"date-parts":[[2023,11,21]],"date-time":"2023-11-21T00:00:00Z","timestamp":1700524800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"name":"Major Project of Sichuan for Science and Technology","award":["2022YFH0025"],"award-info":[{"award-number":["2022YFH0025"]}]}],"content-domain":{"domain":["psychiatryinvestigation.org"],"crossmark-restriction":true},"short-container-title":["Psychiatry Investig"],"published-print":{"date-parts":[[2023,11,25]]},"abstract":"<jats:p>Objective To verify effects of rs1061622 at tumor necrosis factor-\u03b1 receptor II (TNF-RII) gene (&lt;i&gt;TNF-RII&lt;\/i&gt;) on post-traumatic stress disorder (PTSD) and its interactive effects with PTSD on serum lipids levels in adolescents.Methods PTSD was measured by PTSD Checklist-Civilian Version (PCL-C) in 699 adolescent survivors at 6 months after Wenchuan earthquake in China. A polymerase chain reaction and restriction fragment length polymorphism assay were utilized for &lt;i&gt;TNF-RII&lt;\/i&gt; rs1061622 genotyping followed by verification using DNA sequencing. Serum triglycerides (TG), total cholesterol (TC), high-density lipoprotein cholesterol (HDL-C), and low-density lipoprotein cholesterol were tested using routine methods.Results G (deoxyguanine) allele carriers had higher PCL-C scores than TT (deoxythymidine) homozygotes in female subjects. Female adolescents had higher PCL-C scores than male subjects in TT homozygotes. Predictors of PTSD prevalence and severity were different between G allele carriers and TT homozygotes. Subjects with PTSD had lower TG, TG\/HDL-C, TC\/HDL-C, and higher HDL-C than adolescents without PTSD in male G allele carriers. G allele carriers had higher TG\/HDL-C and TC\/HDL-C than TT homozygotes in male adolescents without PTSD, and lower TG and TG\/HDL-C in male PTSD patients. G allele carriers had higher TG than TT homozygotes only in female adolescents without PTSD.Conclusion These results suggest reciprocal actions of &lt;i&gt;TNF-RII&lt;\/i&gt; rs1061622 with other factors on PTSD severity, interplays of &lt;i&gt;TNF-RII&lt;\/i&gt; rs1061622 with PTSD on serum lipid levels, and novel treatment strategies for PTSD and comorbidities of PTSD with hyperlipidemia among adolescents with different genetic backgrounds of &lt;i&gt;TNF-RII&lt;\/i&gt; rs1061622 after experiencing traumatic events.<\/jats:p>","DOI":"10.30773\/pi.2023.0089","type":"journal-article","created":{"date-parts":[[2023,11,22]],"date-time":"2023-11-22T01:45:58Z","timestamp":1700617558000},"page":"1045-1053","update-policy":"https:\/\/doi.org\/10.30773\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Associations of TNF-RII rs1061622 With Post-Traumatic Stress Disorder and Their Interplays on Serum Lipids Levels in 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