{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,31]],"date-time":"2026-07-31T23:54:38Z","timestamp":1785542078799,"version":"3.56.0"},"reference-count":66,"publisher":"Korean Neuropsychiatric Association","issue":"11","license":[{"start":{"date-parts":[[2023,11,21]],"date-time":"2023-11-21T00:00:00Z","timestamp":1700524800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003710","name":"Korea Health Industry Development Institute","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003710","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003625","name":"Ministry of Health and Welfare","doi-asserted-by":"publisher","award":["HI22C0520"],"award-info":[{"award-number":["HI22C0520"]}],"id":[{"id":"10.13039\/501100003625","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"publisher","award":["2021M3E5D9025022"],"award-info":[{"award-number":["2021M3E5D9025022"]}],"id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["psychiatryinvestigation.org"],"crossmark-restriction":true},"short-container-title":["Psychiatry Investig"],"published-print":{"date-parts":[[2023,11,25]]},"abstract":"<jats:p>Objective This review aims to investigate the progression of neuroablation, along with documented clinical efficacy and safety, in the management of treatment-resistant obsessive-compulsive disorder (OCD).Methods We searched and compiled clinical research results of neuroablation therapy reported to date. We extracted outcomes related to clinical efficacy, side effects, and surgical complications. Additionally, we summarized key claims and findings.Results Neuroablative intervention is a potential treatment approach for refractory OCD. Recent advancements, such as real-time magnetic resonance monitoring and minimally invasive techniques employing ultrasound and laser, offer distinct advantages in terms of safety and comparative efficacy when compared to conventional methods. However, the absence of randomized controlled trials and long-term outcome data underscores the need for cautious consideration when selecting neuroablation.Conclusion Neuroablative intervention shows promise for refractory OCD, but vigilant consideration is essential in both patient selection and surgical method choices due to the potential for rare yet serious complications.<\/jats:p>","DOI":"10.30773\/pi.2023.0214","type":"journal-article","created":{"date-parts":[[2023,11,22]],"date-time":"2023-11-22T01:45:58Z","timestamp":1700617558000},"page":"997-1006","update-policy":"https:\/\/doi.org\/10.30773\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Neuroablative Intervention for Refractory Obsessive-Compulsive Disorder"],"prefix":"10.30773","volume":"20","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3024-4893","authenticated-orcid":true,"given":"Jhin Goo","family":"Chang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5438-8210","authenticated-orcid":true,"given":"Se Joo","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8419-3759","authenticated-orcid":true,"given":"Chan-Hyung","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"12228","reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1056\/nejmcp1402176"},{"key":"ref2","first-page":"S74","volume-title":"Clinical practice guidelines for obsessive-compulsive disorder","author":"Reddy","year":"2017"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2019.01.046"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1038\/npp.2009.128"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1016\/j.wneu.2012.11.038"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp-2018-319318"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.3171\/2022.5.jns22474"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1016\/s1042-3680(03)00005-6"},{"key":"ref9","first-page":"6","volume-title":"Concerns about psychiatric neurosurgery and how they can be overcome: recommendations for responsible research","author":"M\u00fcller","year":"2022"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1038\/s41380-020-01007-8"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp-2021-328121"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1007\/s40473-015-0038-1"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1038\/jcbfm.2013.23"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.2967\/jnumed.113.126409"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1038\/s41380-019-0562-6"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.3389\/fpsyt.2021.640832"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.3389\/fnint.2022.797533"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1503\/jpn.190079"},{"key":"ref19","first-page":"236","volume-title":"Prefrontal leucotomy in the treatment of mental disorders. 1937","author":"Moniz","year":"1994"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1097\/00006123-200103000-00041"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1097\/00007611-193701000-00005"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.3389\/fnins.2019.00108"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.1126\/science.106.2754.349"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.1038\/s41380-018-0054-0"},{"key":"ref25","first-page":"S32.e31","volume-title":"Radiosurgery for the treatment of psychiatric disorders: a review","author":"L\u00e9v\u00eaque","year":"2013"},{"key":"ref26","doi-asserted-by":"publisher","DOI":"10.1227\/00006123-199502000-00008"},{"key":"ref27","doi-asserted-by":"publisher","DOI":"10.1016\/j.wneu.2013.02.053"},{"key":"ref28","doi-asserted-by":"publisher","DOI":"10.1001\/archpsyc.65.8.914"},{"key":"ref29","doi-asserted-by":"publisher","DOI":"10.1176\/appi.ajp.160.3.513"},{"key":"ref30","doi-asserted-by":"publisher","DOI":"10.1080\/01616412.1987.11739775"},{"key":"ref31","doi-asserted-by":"publisher","DOI":"10.1002\/lsm.1900130212"},{"key":"ref32","volume-title":"","author":"Ralston"},{"key":"ref33","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp-2021-327730"},{"key":"ref34","doi-asserted-by":"publisher","DOI":"10.1093\/neuros\/nyab050"},{"key":"ref35","doi-asserted-by":"publisher","DOI":"10.1503\/jpn.170188"},{"key":"ref36","doi-asserted-by":"publisher","DOI":"10.1038\/s41380-020-0737-1"},{"key":"ref37","volume-title":"","year":"2019"},{"key":"ref38","doi-asserted-by":"publisher","DOI":"10.1038\/mp.2014.154"},{"key":"ref39","doi-asserted-by":"publisher","DOI":"10.3389\/fnins.2019.00066"},{"key":"ref40","doi-asserted-by":"publisher","DOI":"10.3171\/2015.1.jns14681"},{"key":"ref41","first-page":"1066","volume-title":"Gamma ventral capsulotomy for obsessive-compulsive disorder: a randomized clinical trial","author":"Lopes","year":"2014"},{"key":"ref42","doi-asserted-by":"publisher","DOI":"10.3171\/2019.4.jns19275"},{"key":"ref43","doi-asserted-by":"publisher","DOI":"10.3390\/brainsci9100264"},{"key":"ref44","doi-asserted-by":"publisher","DOI":"10.1016\/j.psyneuen.2012.12.006"},{"key":"ref45","doi-asserted-by":"publisher","DOI":"10.3171\/2014.11.jns132618"},{"key":"ref46","doi-asserted-by":"publisher","DOI":"10.1111\/bdi.12964"},{"key":"ref47","doi-asserted-by":"publisher","DOI":"10.1002\/wps.20299"},{"key":"ref48","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.23.1.56"},{"key":"ref49","doi-asserted-by":"publisher","DOI":"10.1093\/occmed\/kqv054"},{"key":"ref50","volume-title":"","author":"Grace","year":"2001"},{"key":"ref51","doi-asserted-by":"publisher","DOI":"10.1176\/appi.ajp.2011.10111704"},{"key":"ref52","doi-asserted-by":"publisher","DOI":"10.1016\/s0277-9536(98)00009-4"},{"key":"ref53","doi-asserted-by":"publisher","DOI":"10.1001\/archgenpsychiatry.2009.113"},{"key":"ref54","doi-asserted-by":"publisher","DOI":"10.3389\/fnint.2022.802617"},{"key":"ref55","doi-asserted-by":"publisher","DOI":"10.1001\/archpsyc.1989.01810110054008"},{"key":"ref56","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0175748"},{"key":"ref57","doi-asserted-by":"publisher","DOI":"10.31887\/dcns.2014.16.2\/msubramaniam"},{"key":"ref58","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-019-09557-4"},{"key":"ref59","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajp.2023.103473"},{"key":"ref60","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbr.2020.112588"},{"key":"ref61","doi-asserted-by":"publisher","DOI":"10.1523\/jneurosci.2457-12.2013"},{"key":"ref62","doi-asserted-by":"publisher","DOI":"10.1523\/jneurosci.2335-17.2017"},{"key":"ref63","first-page":"S276","volume-title":"Gamma knife capsulotomy for intractable OCD: impact of lesion size and location","author":"McLaughlin","year":"2017"},{"key":"ref64","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awab232"},{"key":"ref65","doi-asserted-by":"publisher","DOI":"10.3389\/neuro.05.002.2010"},{"key":"ref66","doi-asserted-by":"publisher","DOI":"10.1093\/ons\/opaa420"}],"container-title":["Psychiatry Investigation"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/psychiatryinvestigation.org\/upload\/pdf\/pi-2023-0214.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/psychiatryinvestigation.org\/journal\/view.php?doi=10.30773\/pi.2023.0214","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/psychiatryinvestigation.org\/upload\/pdf\/pi-2023-0214.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,24]],"date-time":"2023-11-24T08:03:22Z","timestamp":1700813002000},"score":1,"resource":{"primary":{"URL":"http:\/\/psychiatryinvestigation.org\/journal\/view.php?doi=10.30773\/pi.2023.0214"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,11,25]]},"references-count":66,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2023,11]]}},"URL":"https:\/\/doi.org\/10.30773\/pi.2023.0214","relation":{},"ISSN":["1738-3684","1976-3026"],"issn-type":[{"value":"1738-3684","type":"print"},{"value":"1976-3026","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,11,25]]},"assertion":[{"value":"2023-06-26","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-08-29","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-11-21","order":2,"name":"published","label":"Published online","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-11-25","order":3,"name":"published","label":"Print publication","group":{"name":"publication_history","label":"Publication History"}}]}}