{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T17:03:27Z","timestamp":1740157407874,"version":"3.37.3"},"reference-count":33,"publisher":"Korean Neuropsychiatric Association","issue":"7","license":[{"start":{"date-parts":[[2024,7,24]],"date-time":"2024-07-24T00:00:00Z","timestamp":1721779200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["psychiatryinvestigation.org"],"crossmark-restriction":true},"short-container-title":["Psychiatry Investig"],"published-print":{"date-parts":[[2024,7,25]]},"abstract":"<jats:p>Objective Tacrolimus intrapatient variability (Tac IPV) has been considered a marker for post-graft risk. We investigated pre-transplant psychometric testing to predict Tac IPV after living kidney transplantation.Methods Minnesota Multiphasic Personality Inventory-2 (MMPI-2) examined during pre-transplant evaluation by 102 recipients were analyzed. Subjects were divided into two groups, low IPV (L-IPV) and high IPV (H-IPV), by cutoffs of Tac IPV: median of 24 and value of 30. T-scores of MMPI-2 scales were used to analyze difference between L-IPV and H-IPV using independent t-tests. Stepwise multiple logistic regression was used to test whether MMPI-2 scales affected Tac IPV. Confusion matrix of logistic regression was used to explain statistical power. Cutoff values of significant scales for H-IPV were analyzed by constructing receiver operating characteristic curves.Results Hysteria (Hy) and depression (D) scale scores and Tac IPV were associated in IPV 24 (odds ratio [OR]: 1.08, p&lt;0.01 for Hy; OR: 0.93, p&lt;0.01 for D) and IPV 30 models (OR: 1.09, p&lt;0.01 for Hy; OR: 0.92, p&lt;0.01 for D). Paranoia (Pa) scale scores were associated with Tac IPV in IPV 24 model (OR=1.10, p&lt;0.01) and were significantly higher in H-IPV 24 (p&lt;0.01). F1 scores of confusion matrix in IPV 24 and 30 models were 0.70 and 0.71, respectively. Cutoffs of Hy, D, and Pa scales were 51, 57, and 47, respectively.Conclusion MMPI-2 profile is suggested as a predictor for high Tac IPV after living kidney transplantation.<\/jats:p>","DOI":"10.30773\/pi.2024.0058","type":"journal-article","created":{"date-parts":[[2024,7,24]],"date-time":"2024-07-24T23:42:15Z","timestamp":1721864535000},"page":"718-725","update-policy":"https:\/\/doi.org\/10.30773\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Can Pre-Transplant Psychometric Testing Predict Tacrolimus Intrapatient Variability After Living Kidney Transplantation?"],"prefix":"10.30773","volume":"21","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2509-0105","authenticated-orcid":true,"given":"Ah Rah","family":"Lee","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7834-8272","authenticated-orcid":true,"given":"Sang Min","family":"Lee","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0495-2861","authenticated-orcid":true,"given":"Won Sub","family":"Kang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0652-2929","authenticated-orcid":true,"given":"Ah Rang","family":"Cho","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2739-8664","authenticated-orcid":true,"given":"Jong Woo","family":"Kim","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6624-0010","authenticated-orcid":true,"given":"Jin Kyung","family":"Park","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"12228","reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.2165\/00003088-200443100-00001"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1016\/j.trre.2015.01.002"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1002\/cpt.1618"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1111\/ajt.16002"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.34067\/kid.0002052020"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2021.108392"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.3389\/fpsyt.2017.00250"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1016\/0166-4328(96)00115-5"},{"key":"ref9","first-page":"555","volume-title":"Down regulation of CD45 expression on CD4 T cells during acute renal allograft rejection: evidence of a decline in T suppressor\/inducer activity","author":"Shabtai","year":"2002"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.24869\/psyd.2019.18"},{"key":"ref11","first-page":"571","volume-title":"Relationship between personality and health symptoms: use of the MMPI-2 in medical assessments","author":"Arbisi","year":"2004"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1007\/s11096-017-0436-4"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1080\/00223891.2019.1694527"},{"key":"ref14","first-page":"Doc04","volume-title":"Recording of dissimulation and denial in the context of the psychosomatic evaluation at living kidney transplantation using the Minnesota Multiphasic Personality Inventory (MMPI)","author":"Wutzler","year":"2009"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1016\/j.transproceed.2004.02.054"},{"key":"ref16","first-page":"359","volume-title":"Living donor kidney transplantation: global and regional trend","author":"Nadjafi-Semnani","year":"2021"},{"key":"ref17","first-page":"533","volume-title":"[Korean MMPI-2 standardization study]","author":"Han","year":"2006"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1016\/s0025-6196(12)65299-9"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1111\/ajt.15016"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1016\/j.transproceed.2016.02.081"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1111\/ajt.15199"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1097\/tp.0000000000001129"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-021-91630-4"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.1186\/s12882-020-02017-y"},{"key":"ref25","doi-asserted-by":"publisher","DOI":"10.1097\/md.0000000000005191"},{"key":"ref26","doi-asserted-by":"publisher","DOI":"10.1080\/13854046.2012.742291"},{"key":"ref27","first-page":"347","volume-title":"The MMPI-2 neurotic triad subscales and depression levels after pharmacological treatment in patients with depressive disorders - 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