{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T23:09:09Z","timestamp":1788995349238,"version":"build-2803163510"},"reference-count":28,"publisher":"Korean Neuropsychiatric Association","issue":"9","license":[{"start":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T00:00:00Z","timestamp":1787788800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"name":"Gansu Province Health and Wellness Industry Research Plan Project","award":["GSWSKY2021-034"],"award-info":[{"award-number":["GSWSKY2021-034"]}]},{"name":"Gansu Province Health and Wellness Industry Research Plan Project","award":["GSWSKY2025-75"],"award-info":[{"award-number":["GSWSKY2025-75"]}]}],"content-domain":{"domain":["psychiatryinvestigation.org"],"crossmark-restriction":true},"short-container-title":["Psychiatry Investig"],"published-print":{"date-parts":[[2026,9,25]]},"abstract":"<jats:p>Objective We evaluated the clinical effectiveness of low resistance state thought induction psychotherapy (TIP) in treating adolescent depression and anxiety.Methods This study was registered in the Chinese Clinical Trial Registry (ChiCTR2600119490). One hundred adolescent patients with depression and anxiety admitted to hospital between January 2022 and December 2023 was randomly divided into a control and an experimental group, with 50 cases in each group. The control group received routine pharmacotherapy alone, while the experimental group received TIP technique as an add-on intervention based on the same pharmacotherapy with a treatment course of 3 months. Anxiety scores, electrocardiogram (ECG), liver and kidney function, and hematological parameters were compared between groups at each post-treatment time point. Analysis of variance, Kruskal-Wallis H, and Mann\u2013Whitney tests were used for analysis.Results After treatment, Hamilton Depression Rating Scale and Hamilton Anxiety Rating Scale scores in the experimental group were significantly decreased compared with those in the control group at 2 and 3 months post-treatment (p&lt;0.017). The incidence of abnormal ECG in the experimental group was significantly lower than that in the control group (p=0.017). All the indicators of the experimental group were lower than those of the control group. Hemoglobin and neutrophil-to-lymphocyte ratio in the experimental group were significantly higher than those in the control group at 3 months (p&lt;0.017).Conclusion TIP as an add-on intervention can significantly reduce the incidence of abnormal ECGs and the damage to liver and kidney function, alleviate symptoms of depression and anxiety in adolescent patients.<\/jats:p>","DOI":"10.30773\/pi.2025.0163","type":"journal-article","created":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T07:46:28Z","timestamp":1787730388000},"page":"1163-1171","update-policy":"https:\/\/doi.org\/10.30773\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["The Thought Induction Psychotherapy Technique\u2019s Clinical Effectiveness in Treating Adolescent Depression and Anxiety: A Randomized Controlled Trial"],"prefix":"10.30773","volume":"23","author":[{"ORCID":"https:\/\/orcid.org\/0009-0008-2033-4629","authenticated-orcid":true,"given":"Yaqi","family":"Feng","sequence":"first","affiliation":[{"name":"Department of Child and Adolescent Psychology, The Second People\u2019s Hospital of Gansu Province, Lanzhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-2303-6342","authenticated-orcid":true,"given":"Rong","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Child and Adolescent Psychology, The Second People\u2019s Hospital of Gansu Province, Lanzhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-1960-0590","authenticated-orcid":true,"given":"Lingyun","family":"Fan","sequence":"additional","affiliation":[{"name":"Department of Child and Adolescent Psychology, The Second People\u2019s Hospital of Gansu Province, Lanzhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-1507-4970","authenticated-orcid":true,"given":"Jing","family":"Tang","sequence":"additional","affiliation":[{"name":"Department of Health management, Gansu University of Chinese Medicine, Lanzhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-6243-7408","authenticated-orcid":true,"given":"Jingxia","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Child and Adolescent Psychology, The Second People\u2019s Hospital of Gansu Province, Lanzhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"12228","reference":[{"key":"ref1","volume-title":"","year":"2022","type":"book"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jclinepi.2024.111623","type":"journal-article"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1016\/j.jadohealth.2019.08.022","type":"journal-article"},{"key":"ref4","first-page":"70","type":"journal-article","volume-title":"Effect of psycho-educational intervention on burden and quality of life among family caregivers of schizophrenic 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technique on coke, depression and sleep quality in patients with chronic kidney disease]","author":"Li","year":"2021"},{"key":"ref24","first-page":"2683","type":"journal-article","volume-title":"[Observation on the efficacy of TCM psychological TIP technique and Chinese medicine acupuncture intervention in patients with mild to moderate depression]","author":"Zheng","year":"2019"},{"key":"ref25","doi-asserted-by":"publisher","DOI":"10.1016\/j.jad.2020.09.127","type":"journal-article"},{"key":"ref26","doi-asserted-by":"publisher","DOI":"10.1093\/braincomms\/fcae263","type":"journal-article"},{"key":"ref27","doi-asserted-by":"publisher","DOI":"10.1016\/j.jad.2020.10.067","type":"journal-article"},{"key":"ref28","first-page":"3","type":"journal-article","volume-title":"Effectiveness of antidepressants in combination with psychotherapy","author":"Alemi","year":"2024"}],"container-title":["Psychiatry 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