{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T20:31:08Z","timestamp":1791232268216,"version":"4.1.0"},"reference-count":106,"publisher":"Korean Neuropsychiatric Association","issue":"2","license":[{"start":{"date-parts":[[2026,2,3]],"date-time":"2026-02-03T00:00:00Z","timestamp":1770076800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"name":"Korean Association for Geriatric Psychiatry"},{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"publisher","award":["RS-2024-00450828"],"award-info":[{"award-number":["RS-2024-00450828"]}],"id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100014188","name":"Ministry of Science and ICT","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100014188","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["psychiatryinvestigation.org"],"crossmark-restriction":true},"short-container-title":["Psychiatry Investig"],"published-print":{"date-parts":[[2026,2,25]]},"abstract":"<jats:p>Objective This review overviewed the recent paradigm shifts in the diagnosis and management of Alzheimer\u2019s disease (AD), emphasizing the 2024 Alzheimer\u2019s Association (AA) revised criteria, advances in cerebrospinal fluid (CSF) and blood-based biomarkers (BBMs), and practical considerations for anti-amyloid monoclonal antibody therapy.Methods We conducted a narrative appraisal of consensus frameworks (2018 National Institute on Aging\u2013Alzheimer\u2019s Association [NIA-AA] amyloid, tau, and neurodegeneration [AT(N)] and the 2024 AA criteria), clinical practice guidance from AA released in 2025, regulatory status of CSF and BBMs. Intended-use settings (triage vs. confirmatory) of BBMs and implementation of anti-amyloid anti-body treatments (lecanemab or donanemab) in real-world practice in Korea were also reviewed.Results The 2024 AA criteria define AD biologically and designate A and T as core biomarkers; Core 1 biomarkers can establish AD irrespective of symptoms, whereas Core 2 biomarkers refine staging. A two-cutoff BBM strategy (positive\/intermediate\/negative) reduces misclassification and guides confirmatory CSF\/positron emission tomography (PET) or retesting. BBMs now approach CSF\/PET accuracy for amyloid detection, enable triage and, in selected settings, confirmation, and show utility for monitoring treatment response. Integration of clinical stages (1\u20136) with biological stages (A\u2013D) clarifies syndrome\u2013pathology discordance. Special scenarios\u2014maintenance after induction, APOE \u03b54 homozygotes, Down syndrome, and serious mental illness\u2014require individualized risk\u2013benefit assessment. In South Korea, constrained access to tau PET and some BBMs necessitates Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition, Text Revision\u2013anchored evaluation with selective biomarker testing.Conclusion Biomarker-oriented diagnosis and anti-amyloid therapies are reshaping AD care. Priorities include rigorous validation of BBMs across populations, equitable access to core biomarkers, safety strategies, and real-world evidence to implement maintenance and special-population care pathways.<\/jats:p>","DOI":"10.30773\/pi.2025.0400","type":"journal-article","created":{"date-parts":[[2026,2,3]],"date-time":"2026-02-03T23:40:25Z","timestamp":1770162025000},"page":"183-200","update-policy":"https:\/\/doi.org\/10.30773\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Evolving Alzheimer\u2019s Disease Clinical Practice: Updated Diagnostic Criteria, Fluid Biomarkers, and Special Considerations for Anti-Amyloid Therapies"],"prefix":"10.30773","volume":"23","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1333-358X","authenticated-orcid":true,"given":"Hyun 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