{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T05:47:48Z","timestamp":1791870468551,"version":"4.3.4"},"reference-count":29,"publisher":"Korean Neuropsychiatric Association","issue":"10","license":[{"start":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T00:00:00Z","timestamp":1790121600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["psychiatryinvestigation.org"],"crossmark-restriction":true},"short-container-title":["Psychiatry Investig"],"published-print":{"date-parts":[[2026,10,25]]},"abstract":"<jats:p>Objective This study aimed to compare peripheral inflammatory markers between patients presenting after a suicide attempt and healthy controls, and to examine differences between first-time and multiple attempters.Methods This retrospective cross-sectional study included 90 patients presenting after a suicide attempt and 107 age- and sex-matched controls without psychiatric disorders between 2017 and 2024. Peripheral inflammatory indices, including neutrophil-to-lymphocyte ratio (NLR), monocyte-to-lymphocyte ratio (MLR), basophil-to-lymphocyte ratio (BLR), and neutrophil-to-albumin ratio (NAR), were calculated from complete blood count parameters. C-reactive protein (CRP) data were available only for the patient group. Group comparisons used the independent samples t-test or Mann\u2013Whitney U test, and correlations were assessed with Spearman\u2019s rho. Statistical significance was set at p&lt;0.05.Results Compared with controls, patients with suicide attempts had significantly higher white blood cell, neutrophil, and monocyte counts, as well as higher inflammatory indices (NLR, MLR, NAR; all p&lt;0.01), and lower albumin, hemoglobin, and hematocrit levels (all p&lt;0.01). BLR was significantly higher in individuals with multiple suicide attempts compared to first-time attempters (p=0.023) and showed a weak positive correlation with the number of attempts (r=0.246, p=0.019). CRP, NLR, MLR, and NAR were positively correlated with the number of psychiatric hospitalizations. No significant sex-based differences were observed in inflammatory indices.Conclusion Peripheral inflammatory markers were altered in patients presenting after a suicide attempt. BLR showed a modest association with multiple suicide attempts. These findings are preliminary and should be confirmed in prospective studies.<\/jats:p>","DOI":"10.30773\/pi.2026.0168","type":"journal-article","created":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T07:28:42Z","timestamp":1790062122000},"page":"1248-1255","update-policy":"https:\/\/doi.org\/10.30773\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Association Between Peripheral Inflammatory and Hematological Markers and Suicide Attempts: A Retrospective Case\u2013Control Study"],"prefix":"10.30773","volume":"23","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2057-4947","authenticated-orcid":true,"given":"Ezgi Sel\u00e7uk","family":"\u00d6zmen","sequence":"first","affiliation":[{"name":"Department of Psychiatry, Trabzon Fatih State Hospital, Trabzon, T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9853-745X","authenticated-orcid":true,"given":"Asl\u0131 Enzel","family":"Ko\u00e7","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, Faculty of Medicine, Trabzon University, Trabzon, T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"12228","reference":[{"key":"ref1","first-page":"46","type":"journal-article","volume-title":"Overview of mental health: a public health priority","author":"Matlala","year":"2018"},{"key":"ref2","first-page":"3","type":"book","volume-title":"","author":"Ruch","year":"2022"},{"key":"ref3","volume-title":"","year":"2021","type":"book"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1080\/15374416.2014.910789","type":"journal-article"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.3390\/brainsci13030505","type":"journal-article"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1007\/s11920-017-0781-y","type":"journal-article"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbih.2025.101002","type":"journal-article"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1089\/cap.2008.0140","type":"journal-article"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2014.10.014","type":"journal-article"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1016\/j.euroneuro.2013.06.002","type":"journal-article"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1186\/s12991-025-00575-9","type":"journal-article"},{"key":"ref12","first-page":"1","type":"journal-article","volume-title":"Psychiatric disorders at the crossroads of neurovascular, immune, and metabolic dysregulation: examining comorbidities from a biopsychosocial and dimensional perspective across the lifespan","author":"Eser","year":"2025"},{"key":"ref13","first-page":"275","type":"journal-article","volume-title":"Evaluation of the correlation between peripheral inflammatory markers and suicide risk in drug-naive first-episode schizophrenia","author":"Ye\u015filkaya","year":"2024"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1017\/s0033291719001685","type":"journal-article"},{"key":"ref15","first-page":"32","type":"journal-article","volume-title":"Inflammatory biomarkers, cognitive functioning, and brain imaging abnormalities in bipolar disorder: a systematic review","author":"Mario","year":"2024"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpsychires.2022.04.002","type":"journal-article"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpsychires.2025.09.006","type":"journal-article"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1192\/j.eurpsy.2023.18","type":"journal-article"},{"key":"ref19","first-page":"368","type":"journal-article","volume-title":"Evaluation of peripheral inflammatory parameters of cases with suicide attempts","author":"K\u0131l\u0131\u00e7","year":"2024"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1080\/08039488.2017.1363285","type":"journal-article"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1080\/15321819.2018.1529682","type":"journal-article"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-065x.2011.01023.x","type":"journal-article"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.1038\/nrn1824","type":"journal-article"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.1038\/nrn2297","type":"journal-article"},{"key":"ref25","doi-asserted-by":"publisher","DOI":"10.1016\/s1043-2760(99)00188-5","type":"journal-article"},{"key":"ref26","doi-asserted-by":"publisher","DOI":"10.1186\/s12888-025-07616-3","type":"journal-article"},{"key":"ref27","first-page":"e20244026","type":"journal-article","volume-title":"Exploring the role of impulsivity, aggression, lipid profiles, and inflammatory markers in suicide attempts: a crossdiagnostic study","author":"Gok\u00e7ay","year":"2025"},{"key":"ref28","doi-asserted-by":"publisher","DOI":"10.7759\/cureus.17459","type":"journal-article"},{"key":"ref29","doi-asserted-by":"publisher","DOI":"10.3390\/ijms23031616","type":"journal-article"}],"container-title":["Psychiatry Investigation"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/psychiatryinvestigation.org\/upload\/pdf\/pi-2026-0168.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/psychiatryinvestigation.org\/journal\/view.php?doi=10.30773\/pi.2026.0168","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/psychiatryinvestigation.org\/upload\/pdf\/pi-2026-0168.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T05:29:47Z","timestamp":1791869387000},"score":1,"resource":{"primary":{"URL":"http:\/\/psychiatryinvestigation.org\/journal\/view.php?doi=10.30773\/pi.2026.0168"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,10,25]]},"references-count":29,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2026,10]]}},"URL":"https:\/\/doi.org\/10.30773\/pi.2026.0168","relation":{},"ISSN":["1976-3026"],"issn-type":[{"value":"1976-3026","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,10,25]]},"assertion":[{"value":"2026-05-02","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-06-30","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-09-23","order":2,"name":"published","label":"Published online","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-10-25","order":3,"name":"published","label":"Print publication","group":{"name":"publication_history","label":"Publication History"}}]}}