{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,28]],"date-time":"2025-10-28T15:06:12Z","timestamp":1761663972118},"reference-count":0,"publisher":"American Association for Laboratory Animal Science","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["comp med"],"published-print":{"date-parts":[[2019,10,1]]},"abstract":"<jats:p>Sheep are commonly used as animal models for human biomedical research, but descriptions of their use for studying the pharmacokinetics of carbapenem antimicrobials, such as ertapenem, are unavailable. Ertapenem is a critical antimicrobial for human infections, and the description of\n the pharmacokinetics of this drug is of value for research using ovine as models for human diseases, such as urinary tract infections (UTI). There are currently no ovine models for comparative biomedical research of UTI. The objective of this study was to report the pharmacokinetics of ertapenem\n in sheep after single and multiple dosing. In addition, we explored the effects of an immunomodulatory drug (Zelnate) on the pharmacokinetics of ertapenem in sheep. Eight healthy ewes (weight, 64.4 \u00b1 7.7 kg) were used in an ovine bacterial cystitis model of human cystitis with <jats:italic>Pseudomonas\n aeruginosa<\/jats:italic>. After disease confirmation, each ewe received 1 g of ertapenem intravenously once every 24 h for 5 administrations. Blood was collected intensively (14 samples) during 24 h after the first and last administration. After multiple-dose administration, the volume of distribution\n was 84.5 mL\/kg, clearance was 116.3 mL\/h\/kg, T1\/2<jats:sub>(<\/jats:sub>\u03bb<jats:sub>z)<\/jats:sub> was 1.1 h, and the extraction ratio was 0.02. No significant differences in pharmacokinetic parameters or time points were found between groups treated with the immunostimulant and controls or after the 1st\n or 5th administration of ertapenem. No accumulation was noted from previous administration. Our ovine pharmacokinetic findings can be used to evaluate therapeutic strategies for ertapenem use (varying drug dosing schedules and combinations with other antimicrobials or immune modulators) in\n the context of UTI.<\/jats:p>","DOI":"10.30802\/aalas-cm-18-000144","type":"journal-article","created":{"date-parts":[[2019,10,3]],"date-time":"2019-10-03T21:06:52Z","timestamp":1570136812000},"page":"413-418","source":"Crossref","is-referenced-by-count":6,"title":["Pharmacokinetics of Ertapenem in Sheep (<i>Ovis aries<\/i>) with Experimentally Induced Urinary Tract Infection"],"prefix":"10.30802","volume":"69","author":[{"given":"Joe S","family":"Smith","sequence":"first","affiliation":[{"name":"Veterinary Diagnostic and Production Animal Medicine, Iowa State University, Ames, Iowa: Systems Modelling and Reverse Translational (SMART) Pharmacology, Iowa State University, Ames, Iowa;, Email: jss303@iastate.edu"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David J","family":"Borts","sequence":"additional","affiliation":[{"name":"Veterinary Diagnostic and Production Animal Medicine, Iowa State University, Ames, Iowa"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Clare C","family":"Slagel","sequence":"additional","affiliation":[{"name":"Analytical Chemistry Services, Iowa State University, Ames, Iowa"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Suzanne M","family":"Rajewski","sequence":"additional","affiliation":[{"name":"Analytical Chemistry Services, Iowa State University, Ames, Iowa"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alain","family":"Bousquet-Melou","sequence":"additional","affiliation":[{"name":"INTHERES, Universit\u00e9 de Toulouse, INRA, ENVT, Toulouse, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aude A","family":"Ferran","sequence":"additional","affiliation":[{"name":"INTHERES, Universit\u00e9 de Toulouse, INRA, ENVT, Toulouse, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paul J","family":"Plummer","sequence":"additional","affiliation":[{"name":"Veterinary Diagnostic and Production Animal Medicine, Iowa State University, Ames, Iowa; Veterinary Microbiology and Preventative Medicine, Iowa State University, Ames, Iowa; National Institute of Antimicrobial Resistance Research\n and Education, Ames, Iowa"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jon P","family":"Mochel","sequence":"additional","affiliation":[{"name":"Veterinary Diagnostic and Production Animal Medicine, Iowa State University, Ames, Iowa; Systems Modelling and Reverse Translational (SMART) Pharmacology, Iowa State University, Ames, Iowa"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"12258","container-title":["Comparative Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ingentaconnect.com\/content\/aalas\/cm\/2019\/00000069\/00000005\/art00006","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,10,22]],"date-time":"2019-10-22T00:33:44Z","timestamp":1571704424000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ingentaconnect.com\/content\/10.30802\/AALAS-CM-18-000144"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,10,1]]},"references-count":0,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2019,10,1]]}},"alternative-id":["1532-0820(20191001)69:5L.413;1-"],"URL":"https:\/\/doi.org\/10.30802\/aalas-cm-18-000144","relation":{},"ISSN":["1532-0820"],"issn-type":[{"type":"print","value":"1532-0820"}],"subject":[],"published":{"date-parts":[[2019,10,1]]}}}