{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,10,16]],"date-time":"2024-10-16T04:21:05Z","timestamp":1729052465131},"reference-count":58,"publisher":"American Association for Laboratory Animal Science","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["comp med"],"published-print":{"date-parts":[[2023,8,27]]},"abstract":"<jats:p>Fibrosis that occurs after nonfatal myocardial infarction (MI) is an irreversible reparative cardiac tissue remodeling process characterized by progressive deposition of highly cross-linked type I collagen. No currently available therapeutic strategy prevents or reverses MI-associated\n fibrotic scarring of myocardium. In this study, we used an epicardial graft prepared of porcine cholecystic extracellular matrix to treat experimental nonfatal MI in rats. Graft-assisted healing was characterized by reduced fibrosis, with scanty deposition of type I collagen. Histologically,\n the tissue response was associated with a favorable regenerative reaction predominated by CD4-positive helper T lymphocytes, enhanced angiogenesis, and infiltration of proliferating cells. These observations indicate that porcine cholecystic extracellular matrix delayed the fibrotic reaction\n and support its use as a potential biomaterial for mitigating fibrosis after MI. Delaying the progression of cardiac tissue remodeling may widen the therapeutic window for management of scarring after MI.<\/jats:p>","DOI":"10.30802\/aalas-cm-22-000097","type":"journal-article","created":{"date-parts":[[2023,8,1]],"date-time":"2023-08-01T21:06:35Z","timestamp":1690923995000},"page":"311-322","source":"Crossref","is-referenced-by-count":2,"title":["Mitigation of Fibrosis after Myocardial Infarction in Rats by Using a Porcine Cholecyst Extracellular Matrix"],"prefix":"10.30802","volume":"73","author":[{"given":"Reshma S","family":"Nair","sequence":"first","affiliation":[{"name":"Division of Experimental Pathology; Department of Biochemistry and Molecular Medicine, Universit\u00e9 de Montr\u00e9al and Montreal Heart Institute, Montr\u00e9al, Qu\u00e9bec, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Praveen K","family":"Sobhan","sequence":"additional","affiliation":[{"name":"Division of Tissue Culture"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sachin J","family":"Shenoy","sequence":"additional","affiliation":[{"name":"Division of In Vivo Models and Testing, Department of Applied Biology, Biomedical Technology Wing, Sree Chitra Tirunal Institute for Medical Sciences and Technology, Thiruvananthapuram, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mukund A","family":"Prabhu","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Sree Chitra Tirunal Institute for Medical Sciences and Technology, Thiruvananthapuram, India; Department of Cardiology, Kasturba Medical College Manipal, Manipal Academy of Higher Education, Manipal,\n Karnataka"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vikas","family":"Kumar","sequence":"additional","affiliation":[{"name":"Cardiovascular Diseases and Diabetes Biology, Rajiv Gandhi Centre for Biotechnology, Thiruvananthapuram, India Current affiliations; Diabetes Research Program, Department of Medicine, New York University School of Medicine, New York"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Surya","family":"Ramachandran","sequence":"additional","affiliation":[{"name":"Cardiovascular Diseases and Diabetes Biology, Rajiv Gandhi Centre for Biotechnology, Thiruvananthapuram, India Current affiliations"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thapasimuthu V","family":"Anilkumar","sequence":"additional","affiliation":[{"name":"Division of Experimental Pathology; Corresponding author., Email: tvanilkumar@sctimst.ac.in"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"12258","reference":[{"key":"R66_358_703","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1016\/j.addr.2014.08.006","volume":"84","journal-title":"Adv Drug Deliv Rev","ISSN":"http:\/\/id.crossref.org\/issn\/0169-409X","issn-type":"print"},{"key":"R66_498_664","doi-asserted-by":"crossref","first-page":"585","DOI":"10.1038\/s41569-018-0036-6","volume":"15","journal-title":"Nat Rev Cardiol","ISSN":"http:\/\/id.crossref.org\/issn\/0957-3526","issn-type":"print"},{"key":"R66_433_588","doi-asserted-by":"crossref","first-page":"1600","DOI":"10.1172\/JCI87491","volume":"127","journal-title":"J Clin Invest","ISSN":"http:\/\/id.crossref.org\/issn\/0021-9738","issn-type":"print"},{"key":"R66_389_559","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1161\/CIRCRESAHA.111.243162","volume":"110","journal-title":"Circ Res","ISSN":"http:\/\/id.crossref.org\/issn\/0009-7330","issn-type":"print"},{"key":"R66_530_530","doi-asserted-by":"crossref","first-page":"14933","DOI":"10.1038\/s41598-019-49575-2","volume":"9","journal-title":"Sci Rep","ISSN":"http:\/\/id.crossref.org\/issn\/0022-8338","issn-type":"print"},{"key":"R66_382_501","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1161\/CIRCRESAHA.118.313261","volume":"123","journal-title":"Circ Res","ISSN":"http:\/\/id.crossref.org\/issn\/0009-7330","issn-type":"print"},{"key":"R66_431_453","first-page":"141","volume":"2","journal-title":"ENGINEERING -LONDON THEN SOLIHULL-","ISSN":"http:\/\/id.crossref.org\/issn\/0013-7782","issn-type":"print"},{"key":"R66_366_424","doi-asserted-by":"crossref","first-page":"1225","DOI":"10.1161\/CIRCULATIONAHA.112.000438","volume":"128","journal-title":"Circulation","ISSN":"http:\/\/id.crossref.org\/issn\/0009-7322","issn-type":"print"},{"key":"R66_496_328","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1038\/nrcardio.2014.9","volume":"11","journal-title":"Nat Rev Cardiol","ISSN":"http:\/\/id.crossref.org\/issn\/0957-3526","issn-type":"print"},{"key":"R66_434_300","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1177\/0192623317752894","volume":"46","journal-title":"Toxicol Pathol","ISSN":"http:\/\/id.crossref.org\/issn\/0192-6233","issn-type":"print"},{"key":"R66_502_242","first-page":"62","volume":"106","journal-title":"Arq Bras Cardiol","ISSN":"http:\/\/id.crossref.org\/issn\/0013-7782","issn-type":"print"},{"key":"R66_456_204","doi-asserted-by":"crossref","first-page":"1506","DOI":"10.1002\/jbm.b.33131","volume":"102","journal-title":"J Biomed Mater Res B Appl Biomater","ISSN":"http:\/\/id.crossref.org\/issn\/0013-7782","issn-type":"print"},{"key":"R66_330_175","doi-asserted-by":"crossref","first-page":"2053","DOI":"10.1056\/NEJMra1606915","volume":"376","journal-title":"N Engl J Med","ISSN":"http:\/\/id.crossref.org\/issn\/0028-4793","issn-type":"print"},{"key":"R66_476_146","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1016\/j.biomaterials.2016.02.003","volume":"86","journal-title":"Biomaterials","ISSN":"http:\/\/id.crossref.org\/issn\/0142-9612","issn-type":"print"},{"key":"R66_541_626","first-page":"167","volume":"14","journal-title":"Bio- chem (Mosc) Suppl Ser A Membr Cell Biol","ISSN":"http:\/\/id.crossref.org\/issn\/0013-7782","issn-type":"print"},{"key":"R66_506_367","doi-asserted-by":"crossref","first-page":"928","DOI":"10.1021\/bm061088x","volume":"8","journal-title":"Biomacromol- ecules","ISSN":"http:\/\/id.crossref.org\/issn\/1525-7797","issn-type":"print"},{"key":"R67_363_705","first-page":"100","volume":"15","journal-title":"Netherlands Hear J","ISSN":"http:\/\/id.crossref.org\/issn\/0013-7782","issn-type":"print"},{"key":"R67_533_667","doi-asserted-by":"crossref","first-page":"243","DOI":"10.4330\/wjc.v7.i5.243","volume":"7","journal-title":"World J Cardiol","ISSN":"http:\/\/id.crossref.org\/issn\/0013-7782","issn-type":"print"},{"key":"R67_544_638","first-page":"271","volume":"107","journal-title":"Arq Bras Cardiol","ISSN":"http:\/\/id.crossref.org\/issn\/0013-7782","issn-type":"print"},{"key":"R67_330_609","doi-asserted-by":"crossref","first-page":"3304","DOI":"10.1021\/acsabm.0c01627","volume":"4","journal-title":"ACS Appl Bio Mater","ISSN":"http:\/\/id.crossref.org\/issn\/0013-7782","issn-type":"print"},{"key":"R67_413_552","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1016\/j.yjmcc.2015.11.025","volume":"93","journal-title":"J Mol Cell Cardiol","ISSN":"http:\/\/id.crossref.org\/issn\/0022-2828","issn-type":"print"},{"key":"R67_482_523","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1161\/CIRCRESAHA.116.303577","volume":"119","journal-title":"Circ Res","ISSN":"http:\/\/id.crossref.org\/issn\/0009-7330","issn-type":"print"},{"key":"R67_522_494","doi-asserted-by":"crossref","first-page":"63","DOI":"10.3389\/fcell.2019.00063","volume":"7","journal-title":"Front Cell Dev Biol","ISSN":"http:\/\/id.crossref.org\/issn\/0013-7782","issn-type":"print"},{"key":"R67_369_465","doi-asserted-by":"crossref","first-page":"3123","DOI":"10.1038\/s41467-019-11091-2","volume":"10","journal-title":"Nat Commun","ISSN":"http:\/\/id.crossref.org\/issn\/0013-7782","issn-type":"print"},{"key":"R67_412_360","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1016\/j.colsurfb.2017.05.056","volume":"157","journal-title":"Colloids Surf B Biointerfaces","ISSN":"http:\/\/id.crossref.org\/issn\/0013-7782","issn-type":"print"},{"key":"R67_382_321","doi-asserted-by":"crossref","first-page":"743","DOI":"10.3892\/br.2015.500","volume":"3","journal-title":"Biomed Rep","ISSN":"http:\/\/id.crossref.org\/issn\/0013-7782","issn-type":"print"},{"key":"R67_530_292","doi-asserted-by":"crossref","first-page":"536","DOI":"10.1177\/0192623314550722","volume":"43","journal-title":"Toxicol Pathol","ISSN":"http:\/\/id.crossref.org\/issn\/0192-6233","issn-type":"print"},{"key":"R67_356_254","doi-asserted-by":"crossref","first-page":"1302","DOI":"10.1002\/jbm.b.33296","volume":"103","journal-title":"J Biomed Mater Res B Appl Biomater","ISSN":"http:\/\/id.crossref.org\/issn\/0013-7782","issn-type":"print"},{"key":"R67_457_206","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1002\/jbm.b.33567","volume":"105","journal-title":"J Biomed Mater Res B Appl Biomater","ISSN":"http:\/\/id.crossref.org\/issn\/0013-7782","issn-type":"print"},{"key":"R67_412_158","doi-asserted-by":"crossref","first-page":"3320","DOI":"10.1021\/acsabm.0c01648","volume":"4","journal-title":"ACS Appl Bio Mater","ISSN":"http:\/\/id.crossref.org\/issn\/0013-7782","issn-type":"print"},{"key":"R67_360_110","doi-asserted-by":"crossref","first-page":"1057","DOI":"10.1002\/jbm.b.34457","volume":"108","journal-title":"J Biomed Mater Res B Appl Biomater","ISSN":"http:\/\/id.crossref.org\/issn\/0013-7782","issn-type":"print"},{"key":"R67_330_72","doi-asserted-by":"crossref","first-page":"661","DOI":"10.1016\/j.healun.2016.01.012","volume":"35","journal-title":"J Heart Lung Transplant","ISSN":"http:\/\/id.crossref.org\/issn\/1053-2498","issn-type":"print"},{"key":"R67_159_705","doi-asserted-by":"crossref","first-page":"1650","DOI":"10.1016\/j.jtcvs.2013.08.005","volume":"147","journal-title":"J Thorac Cardiovasc Surg","ISSN":"http:\/\/id.crossref.org\/issn\/0022-5223","issn-type":"print"},{"key":"R67_182_657","first-page":"450","volume":"2","journal-title":"JACC Basic Transl Sci","ISSN":"http:\/\/id.crossref.org\/issn\/0013-7782","issn-type":"print"},{"key":"R67_72_609","doi-asserted-by":"crossref","first-page":"11237","DOI":"10.1073\/pnas.1605431113","volume":"113","journal-title":"Proc Natl Acad Sci USA","ISSN":"http:\/\/id.crossref.org\/issn\/0027-8424","issn-type":"print"},{"key":"R67_125_561","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/j.trsl.2017.10.001","volume":"191","journal-title":"Transl Res","ISSN":"http:\/\/id.crossref.org\/issn\/0013-7782","issn-type":"print"},{"key":"R67_108_523","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1038\/s41551-018-0229-7","volume":"2","journal-title":"Nat Biomed Eng","ISSN":"http:\/\/id.crossref.org\/issn\/0013-7782","issn-type":"print"},{"key":"R67_196_456","doi-asserted-by":"crossref","first-page":"13170","DOI":"10.1038\/s41598-019-49666-0","volume":"9","journal-title":"Sci Rep","ISSN":"http:\/\/id.crossref.org\/issn\/0022-8338","issn-type":"print"},{"key":"R67_72_408","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1093\/rb\/rbz017","volume":"6","journal-title":"Regen Biomater","ISSN":"http:\/\/id.crossref.org\/issn\/0013-7782","issn-type":"print"},{"key":"R67_92_369","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1007\/s11259-018-9731-3","volume":"42","journal-title":"Vet Res Commun","ISSN":"http:\/\/id.crossref.org\/issn\/0165-7380","issn-type":"print"},{"key":"R67_72_283","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1038\/s41536-018-0044-5","volume":"3","journal-title":"NPJ Regen Med","ISSN":"http:\/\/id.crossref.org\/issn\/0013-7782","issn-type":"print"},{"key":"R67_72_244","doi-asserted-by":"crossref","first-page":"1377","DOI":"10.1111\/bph.14155","volume":"175","journal-title":"Br J Pharmacol","ISSN":"http:\/\/id.crossref.org\/issn\/0007-1188","issn-type":"print"},{"key":"R67_212_206","doi-asserted-by":"crossref","first-page":"9683","DOI":"10.1126\/scitranslmed.aat9683","volume":"12","journal-title":"Sci Transl Med","ISSN":"http:\/\/id.crossref.org\/issn\/0013-7782","issn-type":"print"},{"key":"R67_237_158","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1016\/j.yjmcc.2015.11.005","volume":"93","journal-title":"J Mol Cell Cardiol","ISSN":"http:\/\/id.crossref.org\/issn\/0022-2828","issn-type":"print"},{"key":"R67_121_129","doi-asserted-by":"crossref","first-page":"15509","DOI":"10.1038\/ncomms15509","volume":"8","journal-title":"Nat Commun","ISSN":"http:\/\/id.crossref.org\/issn\/0013-7782","issn-type":"print"},{"key":"R67_227_62","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/j.addr.2019.05.011","volume":"146","journal-title":"Adv Drug Deliv Rev","ISSN":"http:\/\/id.crossref.org\/issn\/0169-409X","issn-type":"print"},{"key":"R68_150_321","first-page":"1270","volume":"30","journal-title":"Myocyte cell cycle, senescence, and qui- escence. Can J Cardiol","ISSN":"http:\/\/id.crossref.org\/issn\/0013-7782","issn-type":"print"},{"key":"R68_429_340","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1016\/S1071-9164(99)90034-9","volume":"5","journal-title":"J Card Fail","ISSN":"http:\/\/id.crossref.org\/issn\/1071-9164","issn-type":"print"},{"key":"R68_366_302","doi-asserted-by":"crossref","first-page":"613","DOI":"10.1038\/s41419-018-0573-2","volume":"9","journal-title":"Cell Death Dis","ISSN":"http:\/\/id.crossref.org\/issn\/0013-7782","issn-type":"print"},{"key":"R68_406_216","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1016\/j.jtcvs.2018.01.097","volume":"156","journal-title":"J Thorac Cardiovasc Surg","ISSN":"http:\/\/id.crossref.org\/issn\/0022-5223","issn-type":"print"},{"key":"R68_404_81","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1007\/s40778-017-0075-7","volume":"3","journal-title":"Curr Stem Cell Rep","ISSN":"http:\/\/id.crossref.org\/issn\/0013-7782","issn-type":"print"},{"key":"R68_496_52","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1038\/s41551-017-0182-x","volume":"2","journal-title":"Nat Biomed Eng","ISSN":"http:\/\/id.crossref.org\/issn\/0013-7782","issn-type":"print"},{"key":"R68_169_292","doi-asserted-by":"crossref","first-page":"9048","DOI":"10.1016\/j.biomaterials.2013.08.017","volume":"34","journal-title":"Biomaterials","ISSN":"http:\/\/id.crossref.org\/issn\/0142-9612","issn-type":"print"},{"key":"R68_243_235","doi-asserted-by":"crossref","first-page":"16744","DOI":"10.1038\/s41598-019-53351-7","volume":"9","journal-title":"Sci Rep","ISSN":"http:\/\/id.crossref.org\/issn\/0022-8338","issn-type":"print"},{"key":"R68_276_158","doi-asserted-by":"crossref","first-page":"4922","DOI":"10.1172\/JCI123859","volume":"129","journal-title":"J Clin Invest","ISSN":"http:\/\/id.crossref.org\/issn\/0021-9738","issn-type":"print"},{"key":"R68_133_91","first-page":"204173141351","volume":"4","journal-title":"J Tissue Eng","ISSN":"http:\/\/id.crossref.org\/issn\/0013-7782","issn-type":"print"},{"key":"R68_240_52","doi-asserted-by":"crossref","first-page":"1036","DOI":"10.1177\/0885328215615759","volume":"30","journal-title":"J Biomater Appl","ISSN":"http:\/\/id.crossref.org\/issn\/0885-3282","issn-type":"print"},{"key":"R68_269_398","doi-asserted-by":"crossref","first-page":"563","DOI":"10.1007\/s00441-016-2431-9","volume":"365","journal-title":"Cell Tis- sue Res","ISSN":"http:\/\/id.crossref.org\/issn\/0302-766X","issn-type":"print"}],"container-title":["Comparative Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ingentaconnect.com\/content\/aalas\/cm\/2023\/00000073\/00000004\/art00007","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,27]],"date-time":"2023-10-27T00:33:29Z","timestamp":1698366809000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ingentaconnect.com\/content\/10.30802\/AALAS-CM-22-000097"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,8,27]]},"references-count":58,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2023,8,27]]}},"alternative-id":["1532-0820(20230827)73:4L.311;1-"],"URL":"https:\/\/doi.org\/10.30802\/aalas-cm-22-000097","relation":{},"ISSN":["1532-0820"],"issn-type":[{"type":"print","value":"1532-0820"}],"subject":[],"published":{"date-parts":[[2023,8,27]]}}}