{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T03:58:35Z","timestamp":1787025515287,"version":"build-2736575974"},"reference-count":66,"publisher":"American Association for Laboratory Animal Science","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,9]]},"abstract":"<jats:p>Reports of congenital heart disease in nonhuman primates are rare, and double-chambered right ventricle (DCRV), which is a rare congenital heart disease, in which an abnormal muscle bundle divides the right ventricle into 2 chambers (a proximal high-pressure chamber and a distal low-pressure chamber), has not been previously reported. We diagnosed DCRV antemortem in 2 monkeys bred at The Tsukuba Primate Research Center that presented with cardiac murmurs. Subsequent diagnostic evaluation confirmed DCRV in one case, with the other diagnosed with midventricular obstruction having a pathophysiology similar to DCRV. The monkey that had DCRV exhibited a pathophysiology similar to that in humans with DCRV, while the other monkey had a condition mimicking DCRV which was due to a thrombus. We believe this to be the first report of DCRV and a rare DCRV-like pathophysiology due to a thrombus in the ventricle in nonhuman primates.<\/jats:p>","DOI":"10.30802\/aalas-jaalas-25-005","type":"journal-article","created":{"date-parts":[[2025,10,18]],"date-time":"2025-10-18T00:47:41Z","timestamp":1760748461000},"page":"860-864","source":"Crossref","is-referenced-by-count":1,"title":["Double-Chambered Right Ventricle and Intraventricular Thrombosis Mimicking Double-Chambered Right Ventricle in Cynomolgus Monkeys (Macaca fascicularis)"],"prefix":"10.30802","volume":"64","author":[{"given":"Ibuki","family":"Yoneda","sequence":"first","affiliation":[{"name":"Laboratory of Veterinary Physiology, Department of Veterinary Medicine, NIHON University College of Bioresource Sciences, Kanagawa, Japan; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shunya","family":"Nakayama","sequence":"additional","affiliation":[{"name":"Laboratory of Veterinary Physiology, Department of Veterinary Medicine, NIHON University College of Bioresource Sciences, Kanagawa, Japan; and"},{"name":"Tsukuba Primate Research Center, National Institutes of Biomedical Innovation, Health and Nutrition, Ibaraki, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tadashi","family":"Sankai","sequence":"additional","affiliation":[{"name":"Tsukuba Primate Research Center, National Institutes of Biomedical Innovation, Health and Nutrition, Ibaraki, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasuyo","family":"Ito-Fujishiro","sequence":"additional","affiliation":[{"name":"Laboratory of Veterinary Physiology, Department of Veterinary Medicine, NIHON University College of Bioresource Sciences, Kanagawa, Japan; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasuhiro","family":"Yasutomi","sequence":"additional","affiliation":[{"name":"Tsukuba Primate Research Center, National Institutes of Biomedical Innovation, Health and Nutrition, Ibaraki, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroshi","family":"Koie","sequence":"additional","affiliation":[{"name":"Laboratory of Veterinary Physiology, Department of Veterinary Medicine, NIHON University College of Bioresource Sciences, Kanagawa, Japan; and"},{"name":"Tsukuba Primate Research Center, National Institutes of Biomedical Innovation, Health and Nutrition, Ibaraki, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naohide","family":"Ageyama","sequence":"additional","affiliation":[{"name":"Tsukuba Primate Research Center, National Institutes of Biomedical Innovation, Health and Nutrition, Ibaraki, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"12258","reference":[{"key":"bib1","series-title":"Contemp Top Lab Anim Sci.","first-page":"26","article-title":"Echocardiographic diagnosis of muscular ventricular septal defect in a cynomolgus monkey (Macaca fascicularis)","volume":"44","author":"Koie H","year":"2005","unstructured":"Koie H, Ageyama N, Ono F, Kanayama K, Sakai T, Sankai T. 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Echocardiographic evaluation of cardiac function in cynomolgus monkeys over a wide age range. Exp Anim. 2020;69(3):336\u2013344."},{"issue":"2","key":"bib27","series-title":"Am J Vet Res.","first-page":"455","article-title":"Electrocardiogram of the clinically normal, ketamine-sedated Macaca fascicularis","volume":"47","author":"Atkins CE","year":"1986","unstructured":"Atkins CE, Dickie BC. Electrocardiogram of the clinically normal, ketamine-sedated Macaca fascicularis. Am J Vet Res. 1986;47(2):455\u2013457."},{"issue":"3","key":"bib28","series-title":"J Am Soc Echocardiogr.","first-page":"300","article-title":"Double-chambered right ventricle: echocardiographic features","volume":"9","author":"Galiuto L","year":"1996","unstructured":"Galiuto L, O'Leary PW, Seward JB. Double-chambered right ventricle: echocardiographic features. 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Korean Circ J. 2011;41(5):272\u2013275."},{"issue":"1","key":"bib31","series-title":"J Cardiovasc Ultrasound.","first-page":"48","article-title":"Double chambered right ventricle with ventricular septal defect in adults: case series and review of the literature","volume":"23","author":"Moustafa S","year":"2015","unstructured":"Moustafa S, Patton DJ, Alvarez N, et al. Double chambered right ventricle with ventricular septal defect in adults: case series and review of the literature. J Cardiovasc Ultrasound. 2015;23(1):48\u201351."},{"issue":"9","key":"bib32","series-title":"Am J Cardiol.","first-page":"1431","article-title":"Surgical outcomes and postoperative prognosis beyond 10 years for double-chambered right ventricle","volume":"116","author":"Amano M","year":"2015","unstructured":"Amano M, Izumi C, Hayama Y, et al. Surgical outcomes and postoperative prognosis beyond 10 years for double-chambered right ventricle. Am J Cardiol. 2015;116(9):1431\u20131435."},{"issue":"1","key":"bib33","series-title":"J Cardiovasc Echogr.","first-page":"10","article-title":"Role of echocardiograghy in treating a case of double chamber right ventricle with delayed presentation","volume":"27","author":"Barik R","year":"2017","unstructured":"Barik R. Role of echocardiograghy in treating a case of double chamber right ventricle with delayed presentation. J Cardiovasc Echogr. 2017;27(1):10\u201313."},{"key":"bib1","series-title":"Contemp Top Lab Anim Sci.","first-page":"26","article-title":"Echocardiographic diagnosis of muscular ventricular septal defect in a cynomolgus monkey (Macaca fascicularis)","volume":"44","author":"Koie H","year":"2005","unstructured":"Koie H, Ageyama N, Ono F, Kanayama K, Sakai T, Sankai T. Echocardiographic diagnosis of muscular ventricular septal defect in a cynomolgus monkey (Macaca fascicularis). 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