{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,25]],"date-time":"2026-03-25T03:09:38Z","timestamp":1774408178351,"version":"3.50.1"},"reference-count":84,"publisher":"American Association for Laboratory Animal Science","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:p>\n                    Simian T cell leukemia virus (STLV) is associated with lymphoma in many captive and wild Old World nonhuman primate (NHP) species and is readily transmitted by bodily fluids. The disease is best characterized in baboons with a predisposition for aged female animals. Asymptomatic infections are common; however, clinical signs may include generalized lymphadenopathy, lethargy, and anorexia. Herein, we report a case of disseminated lymphoma in a middle-aged female STLV-positive olive baboon (\n                    <jats:italic>Papio anubis<\/jats:italic>\n                    ) that presented with generalized lymphadenopathy and a rapid onset of decreased visual acuity culminating in full vision loss. Postmortem examination revealed a metastatic focus of lymphoma compressing the occipital cortex and is the presumed mechanism of vision loss. To our knowledge, this is the first report of a neurologic complication associated with an STLV infection in a NHP species.\n                  <\/jats:p>","DOI":"10.30802\/aalas-jaalas-25-072","type":"journal-article","created":{"date-parts":[[2025,11,21]],"date-time":"2025-11-21T15:45:17Z","timestamp":1763739917000},"page":"19-24","source":"Crossref","is-referenced-by-count":0,"title":["Acute Cortical Blindness Associated with Occipital Lobe Compression from Simian T Cell Lymphoma Virus Lymphoma in a Baboon (Papio anubis)"],"prefix":"10.30802","volume":"65","author":[{"given":"Carolyn M","family":"Malinowski","sequence":"first","affiliation":[{"name":"Department of Veterinary Medicine and Surgery, The University of Texas MD Anderson Cancer Center, Houston, Texas;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lauren","family":"Hurley","sequence":"additional","affiliation":[{"name":"Chisholm Trail Veterinary Clinic, New Braunfels, Texas; and"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joe H","family":"Simmons","sequence":"additional","affiliation":[{"name":"The Michale E Keeling Center for Comparative Medicine and Research, The University of Texas MD Anderson Cancer Center, Bastrop, Texas"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Martha E","family":"Hensel","sequence":"additional","affiliation":[{"name":"The Michale E Keeling Center for Comparative Medicine and Research, The University of Texas MD Anderson Cancer Center, Bastrop, Texas"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"12258","reference":[{"key":"bib1","series-title":"Viral Diseases of Nonhuman Primates","author":"Morris T","year":"2012","unstructured":"Morris T, Tardif SD, Mansfield K, Abee CR. 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Simian T-cell leukemia virus (STLV) infection in wild primate populations in Cameroon: evidence for dual STLV type 1 and type 3 infection in agile mangabeys (Cercocebus agilis). J Virol. 2004;78(9):4700\u20134709."},{"issue":"4","key":"bib6","series-title":"J Virol.","first-page":"2693","article-title":"Phylogenetic associations of human and simian T-cell leukemia\/lymphotropic virus type I strains: evidence for interspecies transmission","volume":"68","author":"Koralnik IJ","year":"1994","unstructured":"Koralnik IJ, Boeri E, Saxinger WC, et al. Phylogenetic associations of human and simian T-cell leukemia\/lymphotropic virus type I strains: evidence for interspecies transmission. 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Virology. 1998;251(1):71\u201384."},{"issue":"4","key":"bib13","series-title":"Lab Anim Sci.","first-page":"301","article-title":"Spontaneously generated non-Hodgkin\u2019s lymphoma in twenty-seven simian T-cell leukemia virus type 1 antibody-positive baboons (Papio species)","volume":"43","author":"Hubbard GB","year":"1993","unstructured":"Hubbard GB, Mon\u00e9 JP, Allan JS, et al. Spontaneously generated non-Hodgkin\u2019s lymphoma in twenty-seven simian T-cell leukemia virus type 1 antibody-positive baboons (Papio species). Lab Anim Sci. 1993;43(4):301\u2013309."},{"issue":"2","key":"bib14","series-title":"J Med Primatol.","first-page":"61","article-title":"Spontaneous neoplasia in the baboon (Papio spp.)","volume":"36","author":"Cianciolo RE","year":"2007","unstructured":"Cianciolo RE, Butler SD, Eggers JS, et al. Spontaneous neoplasia in the baboon (Papio spp.). J Med Primatol. 2007;36(2):61\u201379."},{"issue":"9","key":"bib15","series-title":"AIDS Res Hum Retroviruses.","first-page":"1653","article-title":"Simian T-cell leukemia virus type I infection in captive baboons","volume":"8","author":"Mone J","year":"1992","unstructured":"Mone J, Whitehead E, Leland M, Hubbard G, Allan JS. Simian T-cell leukemia virus type I infection in captive baboons. AIDS Res Hum Retroviruses. 1992;8(9):1653\u20131661."},{"issue":"6","key":"bib16","series-title":"Aust Vet J.","first-page":"238","article-title":"Incidence of lymphoma in a captive-bred colony of hamadryas baboons (Papio hamadryas)","volume":"87","author":"Graves LE","year":"2009","unstructured":"Graves LE, Hennessy A, Sunderland NS, Heffernan SJ, Thomson SE. Incidence of lymphoma in a captive-bred colony of hamadryas baboons (Papio hamadryas). Aust Vet J. 2009;87(6):238\u2013243."},{"issue":"Suppl 1","key":"bib17","series-title":"Retrovirology.","first-page":"P5","article-title":"Treatment of an aggressive STLV-1 associated lymphoma in a naturally infected baboon","author":"Turpin J","year":"2015","unstructured":"Turpin J, Alais S, Mar\u00e7ais A, et al. Treatment of an aggressive STLV-1 associated lymphoma in a naturally infected baboon. Retrovirology. 2015(Suppl 1):P5."},{"issue":"3","key":"bib18","series-title":"Int J Cancer.","first-page":"333","article-title":"Natural infection in non\u2010human primates with adult T\u2010cell leukemia virus or a closely related agent","volume":"32","author":"Miyoshi I","year":"1983","unstructured":"Miyoshi I, Fujishita M, Taguchi H, Matsubayashi K, Miwa N, Tanioka Y. Natural infection in non\u2010human primates with adult T\u2010cell leukemia virus or a closely related agent. 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Simian T-cell leukemia virus (STLV) infection in wild primate populations in Cameroon: evidence for dual STLV type 1 and type 3 infection in agile mangabeys (Cercocebus agilis). J Virol. 2004;78(9):4700\u20134709."},{"issue":"4","key":"bib6","series-title":"J Virol.","first-page":"2693","article-title":"Phylogenetic associations of human and simian T-cell leukemia\/lymphotropic virus type I strains: evidence for interspecies transmission","volume":"68","author":"Koralnik IJ","year":"1994","unstructured":"Koralnik IJ, Boeri E, Saxinger WC, et al. Phylogenetic associations of human and simian T-cell leukemia\/lymphotropic virus type I strains: evidence for interspecies transmission. 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