{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,16]],"date-time":"2026-04-16T08:49:08Z","timestamp":1776329348730,"version":"3.50.1"},"reference-count":0,"publisher":"Universidad Nacional de C\u00f3rdoba","issue":"2","license":[{"start":{"date-parts":[[2020,4,7]],"date-time":"2020-04-07T00:00:00Z","timestamp":1586217600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Rev Fac Cien Med Univ Nac Cordoba"],"abstract":"<jats:p>Introducci\u00f3n: La microcefalia y las anomal\u00edas cerebrales cong\u00e9nitas pueden deberse a m\u00faltiples etiolog\u00edas, siendo uno de ellas la infecci\u00f3n cong\u00e9nita por el virus Zika (ZIKV). Desde 2016 hasta hoy se han sucedido una serie de brotes del ZIKV en Argentina. M\u00e9todos: La Red Nacional de Anomal\u00edas Cong\u00e9nitas (RENAC) y el Instituto Nacional de Enfermedades Virales (INEVH), dependientes de la Administraci\u00f3n Nacional de Laboratorios e Institutos de Salud \u201cCarlos Malbr\u00e1n\u201d (ANLIS), realizan la vigilancia intensificada de reci\u00e9n nacidos con microcefalia y anomal\u00edas cerebrales. Este trabajo presenta las caracter\u00edsticas cl\u00ednicas y estudios de laboratorio de los pacientes con infecci\u00f3n cong\u00e9nita por ZIKV detectados entre abril de 2016 a marzo 2018. Resultados: se detectaron 10 casos con embriopat\u00eda, seis fueron aut\u00f3ctonos y cuatro importados; en dos casos las madres fueron asintom\u00e1tica durante el embarazo; todos los casos presentaron microcefalia y desproporci\u00f3n cr\u00e1neo facial, ventriculomegalia en siete casos y en seis calcificaciones cerebrales. El diagn\u00f3stico de infecci\u00f3n cong\u00e9nita por Zika en el reci\u00e9n nacido se realiz\u00f3 por estudios serol\u00f3gicos inmunoglobulina M ant\u00edgeno espec\u00edfica (MAC-ELISA) y prueba de neutralizaci\u00f3n por reducci\u00f3n de placas (PRNT90). La PCR fue negativa en todos los casos. Conclusi\u00f3n: Los pacientes presentaron caracter\u00edsticas cl\u00ednicas coincidentes con las reportadas en otros pa\u00edses Se enfatiza la necesidad de estudios serol\u00f3gicos que permitan la confirmaci\u00f3n, descartando la reactividad cruzada con otros Flavivirus<\/jats:p>","DOI":"10.31053\/1853.0605.v77.n2.26754","type":"journal-article","created":{"date-parts":[[2020,6,19]],"date-time":"2020-06-19T10:57:51Z","timestamp":1592564271000},"page":"100-105","source":"Crossref","is-referenced-by-count":1,"title":["Embriopat\u00eda por virus Zika en Argentina: caracter\u00edsticas cl\u00ednicas y diagn\u00f3stico en reci\u00e9n nacidos"],"prefix":"10.31053","volume":"77","author":[{"given":"Ana Laura","family":"Tellechea","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mar\u00eda Paz","family":"Bidondo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Victoria","family":"Luppo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Agust\u00edn","family":"Baricalla","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rosa","family":"Liascovich","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cintia","family":"Fabbri","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mar\u00eda Alejandra","family":"Morales","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Boris","family":"Groisman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mar\u00eda","family":"Silva","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Patricia","family":"Masi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Adriana","family":"Israilev","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marcela Ruth","family":"Rocha","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marcela","family":"Quaglia","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Beatriz","family":"Escalante","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alexandra","family":"Villarreal","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marilena","family":"Antinori","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pablo","family":"Barbero","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"12333","published-online":{"date-parts":[[2020,4,7]]},"container-title":["Revista de la Facultad de Ciencias M\u00e9dicas de C\u00f3rdoba"],"original-title":[],"link":[{"URL":"https:\/\/revistas.unc.edu.ar\/index.php\/med\/article\/download\/26754\/29485","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/revistas.unc.edu.ar\/index.php\/med\/article\/download\/26754\/29870","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/revistas.unc.edu.ar\/index.php\/med\/article\/download\/26754\/29870","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,6,19]],"date-time":"2020-06-19T10:57:52Z","timestamp":1592564272000},"score":1,"resource":{"primary":{"URL":"https:\/\/revistas.unc.edu.ar\/index.php\/med\/article\/view\/26754"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,4,7]]},"references-count":0,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2020,5,20]]}},"URL":"https:\/\/doi.org\/10.31053\/1853.0605.v77.n2.26754","relation":{},"ISSN":["1853-0605","0014-6722"],"issn-type":[{"value":"1853-0605","type":"electronic"},{"value":"0014-6722","type":"print"}],"subject":[],"published":{"date-parts":[[2020,4,7]]}}}