{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,16]],"date-time":"2026-04-16T08:49:14Z","timestamp":1776329354872,"version":"3.50.1"},"reference-count":0,"publisher":"Universidad Nacional de C\u00f3rdoba","issue":"2","license":[{"start":{"date-parts":[[2021,6,28]],"date-time":"2021-06-28T00:00:00Z","timestamp":1624838400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Rev Fac Cien Med Univ Nac Cordoba"],"abstract":"<jats:p>Durante la transici\u00f3n menop\u00e1usica pueden aparecer signos cl\u00ednicos leves de hiperandrogenismo, como parte del proceso de envejecimiento normal, pero el desarrollo de virilizaci\u00f3n franca sugiere una fuente espec\u00edfica de exceso de andr\u00f3genos debiendo descartar la presencia de tumores secretores de andr\u00f3genos tanto a nivel adrenal como ov\u00e1rico.\r\nSe presenta un caso de una mujer de 51 a\u00f1os postmenop\u00e1usica con signos de virilizaci\u00f3n de 12 meses de evoluci\u00f3n, asociado a antecedente personal de diabetes tipo 2 e hipertensi\u00f3n arterial, de mal manejo en el \u00faltimo a\u00f1o. Las pruebas de laboratorio mostraron una franca elevaci\u00f3n de los niveles de andr\u00f3geno s\u00e9rico e hiperinsulinemia asociada. Las im\u00e1genes solicitadas evidenciaron ambos ovarios aumentados de tama\u00f1o de aspecto homog\u00e9neo y s\u00f3lido, con gl\u00e1ndulas adrenales de aspecto conservado, lo que hizo sospechar de una posible hiperplasia tecal del estroma ov\u00e1rico. Se realiz\u00f3 una anexectom\u00eda bilateral por laparoscopia, cuya anatom\u00eda patol\u00f3gica confirm\u00f3 la presunci\u00f3n diagn\u00f3stica. Los dosajes de testosterona s\u00e9rica al mes de la cirug\u00eda retornaron a valores cercanos a la normalidad para una mujer postmenop\u00e1usica.\r\nEl diagn\u00f3stico causal de virilizaci\u00f3n en mujeres posmenop\u00e1usicas es un desaf\u00edo, y por lo general est\u00e1n asociadas con patolog\u00edas poco frecuentes. Una historia cl\u00ednica detallada es fundamental para diferenciar el desarrollo progresivo de virilizaci\u00f3n que caracteriza las causas benignas de la r\u00e1pida progresi\u00f3n que caracteriza a los tumores malignos. La interpretaci\u00f3n de pruebas correctas de laboratorio con im\u00e1genes complementarias, as\u00ed como la b\u00fasqueda de antecedentes de riesgo cardiovascular como la diabetes y la hipertensi\u00f3n asociadas son fundamentales para establecer un correcto diagn\u00f3stico y tratamiento.<\/jats:p>","DOI":"10.31053\/1853.0605.v78.n2.32136","type":"journal-article","created":{"date-parts":[[2021,6,29]],"date-time":"2021-06-29T11:06:42Z","timestamp":1624964802000},"page":"193-196","source":"Crossref","is-referenced-by-count":0,"title":["Virilizaci\u00f3n y enfermedad metab\u00f3lica en mujer postmenop\u00e1usica relacionado a hiperplasia e hipertecosis ov\u00e1rica"],"prefix":"10.31053","volume":"78","author":[{"given":"Agustina Lucila","family":"Larrea","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vicente Ricardo","family":"Gonz\u00e1lez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pablo","family":"Knoblovits","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Santiago Jos\u00e9","family":"Gil","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"12333","published-online":{"date-parts":[[2021,6,28]]},"container-title":["Revista de la Facultad de Ciencias M\u00e9dicas de C\u00f3rdoba"],"original-title":[],"link":[{"URL":"https:\/\/revistas.unc.edu.ar\/index.php\/med\/article\/download\/32136\/33985","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/revistas.unc.edu.ar\/index.php\/med\/article\/download\/32136\/33987","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/revistas.unc.edu.ar\/index.php\/med\/article\/download\/32136\/33985","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,6,29]],"date-time":"2021-06-29T11:06:43Z","timestamp":1624964803000},"score":1,"resource":{"primary":{"URL":"https:\/\/revistas.unc.edu.ar\/index.php\/med\/article\/view\/32136"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,6,28]]},"references-count":0,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2021,6,28]]}},"URL":"https:\/\/doi.org\/10.31053\/1853.0605.v78.n2.32136","relation":{},"ISSN":["1853-0605","0014-6722"],"issn-type":[{"value":"1853-0605","type":"electronic"},{"value":"0014-6722","type":"print"}],"subject":[],"published":{"date-parts":[[2021,6,28]]}}}