{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,16]],"date-time":"2026-04-16T08:49:01Z","timestamp":1776329341446,"version":"3.50.1"},"reference-count":0,"publisher":"Universidad Nacional de C\u00f3rdoba","issue":"2","license":[{"start":{"date-parts":[[2022,6,6]],"date-time":"2022-06-06T00:00:00Z","timestamp":1654473600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Rev Fac Cien Med Univ Nac Cordoba"],"abstract":"<jats:p>El uso terap\u00e9utico del aceite de \u201ccannabis\u201d es una problem\u00e1tica social que pone en tensi\u00f3n aspectos legales, sanitarios, cient\u00edficos y culturales. La dificultad en el acceso genera un vac\u00edo aprovechado por el mercado ilegal, al que recurren pacientes y familiares para mejorar su salud y calidad de vida. Estos aceites, de composici\u00f3n qu\u00edmica desconocida, se emplean sin un seguimiento terap\u00e9utico. Un equipo interdisciplinario de la UNC se involucr\u00f3 en esta problem\u00e1tica con el objetivo de aportar elementos para su caracterizaci\u00f3n en nuestro medio. Metodolog\u00eda: Estudio observacional-descriptivo y transversal (aprobado por el CIEIS-HNC-UNC): entrevistas a pacientes\/cuidadores mayores de edad que usaban el aceite (2019). Estudio experimental: an\u00e1lisis de muestras de aceites de los entrevistados para determinar su contenido de cannabinoides (THC y CBD), mediante HPLC. Resultados: Se realizaron 37 entrevistas y analizaron 48 muestras. El 73% fueron adultos y adultos-mayores. El 79% empiezan a usar el aceite por recomendaci\u00f3n de parientes\/amigos o por iniciativa propia, principalmente por falta de efectividad de otras terapias (54%) y por b\u00fasqueda de alternativas (33%). El 84% lo percibe efectivo (moderado-muy efectivo) y el 78% no manifest\u00f3 eventos adversos. Usos principales: epilepsia refractaria 27% y artritis\/artrosis 24%. El 15% de las muestras no presentaron contenidos cuantificables de CBD y THC, y el 67% present\u00f3 THC sin CBD. El contenido de cannabinoides cuantificables fue muy bajo. Conclusiones: Se obtuvo una aproximaci\u00f3n sobre el uso terap\u00e9utico del aceite de \u201ccannabis\u201d en C\u00f3rdoba y su calidad. Se observ\u00f3 discrepancia entre la efectividad percibida y el bajo contenido de cannabinoides detectados.<\/jats:p>","DOI":"10.31053\/1853.0605.v79.n2.30922","type":"journal-article","created":{"date-parts":[[2022,6,24]],"date-time":"2022-06-24T14:06:59Z","timestamp":1656079619000},"page":"123-131","source":"Crossref","is-referenced-by-count":0,"title":["Caracterizaci\u00f3n de la problem\u00e1tica del uso terap\u00e9utico del Aceite de Cannabis en C\u00f3rdoba, Argentina"],"prefix":"10.31053","volume":"79","author":[{"given":"Pablo Gabriel","family":"Manzo","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sandra","family":"Mart\u00edn","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sonia","family":"Uema","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Germ\u00e1n","family":"Charles","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Felipe","family":"Montero Bruni","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Susana","family":"N\u00fa\u00f1ez Montoya","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mar\u00eda Eugenia","family":"Bertotto","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mart\u00edn","family":"Eynard","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pedro","family":"Armando","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carolina","family":"Bustos Fierro","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"12333","published-online":{"date-parts":[[2022,6,6]]},"container-title":["Revista de la Facultad de Ciencias M\u00e9dicas de C\u00f3rdoba"],"original-title":[],"link":[{"URL":"https:\/\/revistas.unc.edu.ar\/index.php\/med\/article\/download\/30922\/37665","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/revistas.unc.edu.ar\/index.php\/med\/article\/download\/30922\/37535","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/revistas.unc.edu.ar\/index.php\/med\/article\/download\/30922\/37665","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,6,24]],"date-time":"2022-06-24T14:07:00Z","timestamp":1656079620000},"score":1,"resource":{"primary":{"URL":"https:\/\/revistas.unc.edu.ar\/index.php\/med\/article\/view\/30922"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,6,6]]},"references-count":0,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2022,6,6]]}},"URL":"https:\/\/doi.org\/10.31053\/1853.0605.v79.n2.30922","relation":{},"ISSN":["1853-0605","0014-6722"],"issn-type":[{"value":"1853-0605","type":"electronic"},{"value":"0014-6722","type":"print"}],"subject":[],"published":{"date-parts":[[2022,6,6]]}}}