{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,16]],"date-time":"2026-04-16T08:50:56Z","timestamp":1776329456029,"version":"3.50.1"},"reference-count":0,"publisher":"Universidad Nacional de C\u00f3rdoba","issue":"3","license":[{"start":{"date-parts":[[2022,9,16]],"date-time":"2022-09-16T00:00:00Z","timestamp":1663286400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Rev Fac Cien Med Univ Nac Cordoba"],"abstract":"<jats:p>Introducci\u00f3n: Los leiomiosarcomas primarios de piel son neoplasias infrecuentes. Corresponden al 2-3 % de los sarcomas cut\u00e1neos y se localizan con mayor frecuencia en las extremidades inferiores, tronco y genitales.\r\nM\u00e9todos: Presentamos un caso de un var\u00f3n de 73 a\u00f1os con un leiomiosarcoma en prepucio de 4 meses de evoluci\u00f3n. Se le practic\u00f3 biopsia excisional de la lesi\u00f3n para estudio histopatol\u00f3gico con HE e inmunohistoqu\u00edmica con actina de m\u00fasculo liso, actina muscular espec\u00edfica, CD34, p63 y S-100 (-).\u00a0\u00a0\r\nResultados: Observamos un leiomiosarcoma de alto grado histol\u00f3gico y recuento mit\u00f3tico. Present\u00f3 positividad por inmunohistoqu\u00edmica para actina de m\u00fasculo liso, en tanto que los otros marcadores fueron negativos. Los l\u00edmites quir\u00fargicos estuvieron comprometidos por lo que fue necesaria una reintervenci\u00f3n con amplios m\u00e1rgenes de tejido sano.\r\nConclusi\u00f3n: Las lesiones de piel deben extirparse todas, sin excepci\u00f3n, ya que pueden tratarse de neoplasias de conducta biol\u00f3gica variable. El estudio histol\u00f3gico debe complementarse con inmunohistoqu\u00edmica para diferenciarlas de otras neoplasias. Para el pron\u00f3stico se debe tener en cuenta el grado histol\u00f3gico, el tama\u00f1o, la localizaci\u00f3n y la posibilidad de resecci\u00f3n con amplios m\u00e1rgenes.<\/jats:p>","DOI":"10.31053\/1853.0605.v79.n3.34628","type":"journal-article","created":{"date-parts":[[2022,9,20]],"date-time":"2022-09-20T12:29:09Z","timestamp":1663676949000},"page":"294-297","source":"Crossref","is-referenced-by-count":2,"title":["Leiomiosarcoma de prepucio: reporte de un caso"],"prefix":"10.31053","volume":"79","author":[{"given":"Susana","family":"Szlabi","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2347-3930","authenticated-orcid":false,"given":"David","family":"Cremonezzi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"12333","published-online":{"date-parts":[[2022,9,16]]},"container-title":["Revista de la Facultad de Ciencias M\u00e9dicas de C\u00f3rdoba"],"original-title":[],"link":[{"URL":"https:\/\/revistas.unc.edu.ar\/index.php\/med\/article\/download\/34628\/38805","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/revistas.unc.edu.ar\/index.php\/med\/article\/download\/34628\/38805","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,9,20]],"date-time":"2022-09-20T12:29:11Z","timestamp":1663676951000},"score":1,"resource":{"primary":{"URL":"https:\/\/revistas.unc.edu.ar\/index.php\/med\/article\/view\/34628"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,9,16]]},"references-count":0,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2022,9,16]]}},"URL":"https:\/\/doi.org\/10.31053\/1853.0605.v79.n3.34628","relation":{},"ISSN":["1853-0605","0014-6722"],"issn-type":[{"value":"1853-0605","type":"electronic"},{"value":"0014-6722","type":"print"}],"subject":[],"published":{"date-parts":[[2022,9,16]]}}}