{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,16]],"date-time":"2026-04-16T08:51:14Z","timestamp":1776329474316,"version":"3.50.1"},"reference-count":0,"publisher":"Universidad Nacional de C\u00f3rdoba","issue":"3","license":[{"start":{"date-parts":[[2022,9,16]],"date-time":"2022-09-16T00:00:00Z","timestamp":1663286400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Rev Fac Cien Med Univ Nac Cordoba"],"abstract":"<jats:p>Introducci\u00f3n. La cetoacidosis diab\u00e9tica (CAD) es una complicaci\u00f3n potencialmente mortal caracterizada por hiperglucemia, acidosis metab\u00f3lica y cetonemia. Aunque el tiempo para la resoluci\u00f3n de la CAD se ha estimado en 12 a 18 horas, los factores que podr\u00edan prolongarlo no se han estudiado con exhaustividad.\r\nM\u00e9todos. Estudio retrospectivo de historias cl\u00ednicas de pacientes adultos admitidos a sala general con diagn\u00f3stico de CAD. Se clasificaron seg\u00fan la severidad en leve, moderada y severa. El tiempo de resoluci\u00f3n de la crisis (TRC) se defini\u00f3 como aquel necesario hasta normalizaci\u00f3n de par\u00e1metros metab\u00f3licos. Se realiz\u00f3 un an\u00e1lisis de regresi\u00f3n log\u00edstica para evaluar la asociaci\u00f3n entre TRC&gt;12 horas y variables continuas. Se realiz\u00f3 un an\u00e1lisis ROC y un an\u00e1lisis de supervivencia utilizando un modelo de regresi\u00f3n de Cox.\r\nResultados. Se estudiaron 85 pacientes. El 48.23% present\u00f3 CAD severa. El TRC fue de 14 horas, siendo mayor en CAD severa. Los pacientes con TRC&gt;12 horas presentaron menor pH y HCO3, y mayor ani\u00f3n gap, gl\u00f3bulos blancos y volumen de cristaloides utilizados. El an\u00e1lisis de regresi\u00f3n log\u00edstica demostr\u00f3 que el pH y el volumen de cristaloides correlacionaron con TRC&gt;12 horas. El an\u00e1lisis ROC determin\u00f3 un valor de corte de pH de 7.13 para TRC&gt;12 horas (sensibilidad 77%, especificidad 88%). La regresi\u00f3n de Cox demostr\u00f3 que un pH &lt;7.13 al ingreso se asocia a mayor TRC (HR 3.30).\r\nConclusi\u00f3n. Un pH menor a 7.13 al momento de admisi\u00f3n hospitalaria identifica a pacientes con CAD que necesitar\u00e1n un mayor tiempo para resolver sus par\u00e1metros metab\u00f3licos.<\/jats:p>","DOI":"10.31053\/1853.0605.v79.n3.34968","type":"journal-article","created":{"date-parts":[[2022,9,20]],"date-time":"2022-09-20T12:29:07Z","timestamp":1663676947000},"page":"223-227","source":"Crossref","is-referenced-by-count":0,"title":["An\u00e1lisis de las variables involucradas en el tiempo de resoluci\u00f3n de los par\u00e1metros metab\u00f3licos en adultos con cetoacidosis diab\u00e9tica"],"prefix":"10.31053","volume":"79","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8212-1257","authenticated-orcid":false,"given":"Luis Agust\u00edn","family":"Ram\u00edrez Stieben","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paula Mar\u00eda","family":"Gago Noble","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mar\u00eda Celia","family":"Jaimet","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"12333","published-online":{"date-parts":[[2022,9,16]]},"container-title":["Revista de la Facultad de Ciencias M\u00e9dicas de C\u00f3rdoba"],"original-title":[],"link":[{"URL":"https:\/\/revistas.unc.edu.ar\/index.php\/med\/article\/download\/34968\/38810","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/revistas.unc.edu.ar\/index.php\/med\/article\/download\/34968\/38837","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/revistas.unc.edu.ar\/index.php\/med\/article\/download\/34968\/38810","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,9,20]],"date-time":"2022-09-20T12:29:07Z","timestamp":1663676947000},"score":1,"resource":{"primary":{"URL":"https:\/\/revistas.unc.edu.ar\/index.php\/med\/article\/view\/34968"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,9,16]]},"references-count":0,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2022,9,16]]}},"URL":"https:\/\/doi.org\/10.31053\/1853.0605.v79.n3.34968","relation":{},"ISSN":["1853-0605","0014-6722"],"issn-type":[{"value":"1853-0605","type":"electronic"},{"value":"0014-6722","type":"print"}],"subject":[],"published":{"date-parts":[[2022,9,16]]}}}