{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,16]],"date-time":"2026-04-16T08:49:45Z","timestamp":1776329385221,"version":"3.50.1"},"reference-count":0,"publisher":"Universidad Nacional de C\u00f3rdoba","issue":"2","license":[{"start":{"date-parts":[[2024,6,28]],"date-time":"2024-06-28T00:00:00Z","timestamp":1719532800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Rev Fac Cien Med Univ Nac Cordoba"],"abstract":"<jats:p>En los tumores s\u00f3lidos la hipereosinofilia es un fen\u00f3meno raro y se asocia principalmente con carcinomas secretores de mucina. Los tumores tiroideos asociados a neutrofilia y\/o eosinofilia se han descrito exclusivamente en pacientes con c\u00e1ncer anapl\u00e1sico de tiroides. La eosinofilia asociada con c\u00e1ncer papilar de tiroides es extremadamente rara y se encuentran muy pocos casos descriptos actualmente. Se ha sugerido que tres citocinas, a saber, la interleucina-3 (IL-3), la interleucina-5 (IL-5) y el factor estimulante de colonias de granulocitos y macr\u00f3fagos (GM-CSF), pueden actuar como un p\u00e9ptido eosinof\u00edlico potencial. Hasta el momento solo se han reportado tres pacientes con c\u00e1ncer diferenciado de tiroides asociados a eosinofilia, dos de tipo papilar y uno de tipo medular. Paciente de 48 a\u00f1os consult\u00f3 en el a\u00f1o 2022 por adenopat\u00edas cervicales bilaterales de 3 a\u00f1os de evoluci\u00f3n asociado a s\u00edndrome consuntivo e hipereosinofilia. Se solicit\u00f3 PET CT que evidenci\u00f3 foco hipermetab\u00f3lico en l\u00f3bulo tiroideo derecho y met\u00e1stasis ganglionares, pulmonares, \u00f3seas y hep\u00e1ticas; ecograf\u00eda tiroidea que evidencia en l\u00f3bulo derecho n\u00f3dulo de alta sospecha de malignidad y conglomerado de adenopat\u00edas con lavado de aguja positivo para tiroglobulina. Evaluada la hipereosinofilia con valores iniciales de leucocitosis de GB 30310\/mm3 (10608\/mm3 de eosin\u00f3filos) hasta valores m\u00e1ximos de GB 77090\/mm3 (eosin\u00f3filos 20814\/mm3) se interpret\u00f3 como s\u00edndrome paraneopl\u00e1sico y se inici\u00f3 corticoterapia en dosis inmunosupresoras sin respuesta. Nuestras observaciones presentadas en este art\u00edculo est\u00e1n en l\u00ednea con la mayor\u00eda de los estudios que reflejan que la hipereosinofilia paraneopl\u00e1sica se caracteriza por una enfermedad m\u00e1s avanzada y un mal pron\u00f3stico.<\/jats:p>","DOI":"10.31053\/1853.0605.v81.n2.44472","type":"journal-article","created":{"date-parts":[[2024,6,28]],"date-time":"2024-06-28T12:37:52Z","timestamp":1719578272000},"page":"403-414","source":"Crossref","is-referenced-by-count":1,"title":["Hipereosinofilia severa como s\u00edndrome paraneopl\u00e1sico en un paciente con c\u00e1ncer diferenciado de tiroides."],"prefix":"10.31053","volume":"81","author":[{"given":"Elizabeth Karen","family":"Videla","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bertha","family":"De la Torre","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pablo","family":"Ferrada","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jorge","family":"Miller","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eduardo","family":"Torres","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anal\u00eda","family":"\u00c1lvarez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Javier","family":"Herrera","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"12333","published-online":{"date-parts":[[2024,6,28]]},"container-title":["Revista de la Facultad de Ciencias M\u00e9dicas de C\u00f3rdoba"],"original-title":[],"link":[{"URL":"https:\/\/revistas.unc.edu.ar\/index.php\/med\/article\/download\/44472\/45480","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/revistas.unc.edu.ar\/index.php\/med\/article\/download\/44472\/45480","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,6,28]],"date-time":"2024-06-28T12:37:53Z","timestamp":1719578273000},"score":1,"resource":{"primary":{"URL":"https:\/\/revistas.unc.edu.ar\/index.php\/med\/article\/view\/44472"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,6,28]]},"references-count":0,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2024,6,28]]}},"URL":"https:\/\/doi.org\/10.31053\/1853.0605.v81.n2.44472","relation":{},"ISSN":["1853-0605","0014-6722"],"issn-type":[{"value":"1853-0605","type":"electronic"},{"value":"0014-6722","type":"print"}],"subject":[],"published":{"date-parts":[[2024,6,28]]}}}