{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,18]],"date-time":"2026-07-18T21:07:15Z","timestamp":1784408835507,"version":"3.55.0"},"reference-count":12,"publisher":"Universidad Nacional de C\u00f3rdoba","issue":"2","license":[{"start":{"date-parts":[[2025,6,26]],"date-time":"2025-06-26T00:00:00Z","timestamp":1750896000000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Rev Fac Cien Med Univ Nac Cordoba"],"abstract":"<jats:p>Objective: Renal cell carcinoma may be associated with highly aggressive behavior and metastatic disease may be present in 30% of patients at the time of diagnosis. The most common sites of metastasis are the lungs, regional lymph nodes, liver, and bones. Metastases at rare sites include gums, larynx, nasal cavity, and thyroid gland. The objective of this article is to report an unusual manifestation of a known disease and present emerging technology useful in patient management.\r\n\u00a0\r\nClinical case: A 60-year-old male patient with a history of renal cell carcinoma. He initially received onco-specific treatment with nephrectomy and, ten years later, with zoledronate, pazopanib, and nivolumab due to metastatic progression. Four months after starting systemic treatment, drug-induced thyroid dysfunction was diagnosed, manifested by fatigue and abnormal laboratory results (TSH 9.23 uUI\/mL). Due to the sensation of a lump in the neck, an ultrasound revealed a thyroid nodule on the right side.\u00a0\r\nAided by doppler ultrasound, and strain elastography, an ultrasound guided fine-needle aspiration biopsy of the thyroid nodule was performed, which confirmed metastasis of renal cell carcinoma.\r\n\u00a0\r\nConclusion: The emergence of a thyroid nodule in patients with a history of renal cell carcinoma and thyroid dysfunction could indicate oncological progression, even a long time after the initial diagnosis.<\/jats:p>","DOI":"10.31053\/1853.0605.v82.n2.45462","type":"journal-article","created":{"date-parts":[[2025,6,26]],"date-time":"2025-06-26T16:19:25Z","timestamp":1750954765000},"page":"419-430","source":"Crossref","is-referenced-by-count":1,"title":["Met\u00e1stasis de carcinoma de c\u00e9lulas renales a la gl\u00e1ndula tiroides tras disfunci\u00f3n tiroidea medicamentosa","Renal cell carcinoma metastasis to the thyroid gland after drug-induced thyroid dysfunction.","Met\u00e1stase de carcinoma de c\u00e9lulas renais para a gl\u00e2ndula tireoide ap\u00f3s disfun\u00e7\u00e3o tireoidiana induzida por drogas"],"prefix":"10.31053","volume":"82","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5348-4681","authenticated-orcid":false,"given":"Juan Bautista","family":"Del Valle","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julio Cesar","family":"Roa Garcia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-2721-4364","authenticated-orcid":false,"given":"Mauricio Arturo","family":"Osorio Monta\u00f1o","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6291-2051","authenticated-orcid":false,"given":"Cristian Andres","family":"Echavarria Cadena","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9939-8260","authenticated-orcid":false,"given":"Jesica Lorena","family":"Savluk","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3302-8985","authenticated-orcid":false,"given":"Mat\u00edas Adri\u00e1n","family":"Borensztein","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"12333","published-online":{"date-parts":[[2025,6,26]]},"reference":[{"key":"ref0","doi-asserted-by":"publisher","unstructured":"1. 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Radiol Bras. 2019;52: 247-253. doi: 10.1590\/0100-3984.2018.0084.","DOI":"10.1590\/0100-3984.2018.0084"},{"key":"ref4","doi-asserted-by":"publisher","unstructured":"5. Nguyen M, He G, Lam AK-Y. Clinicopathological and Molecular Features of Secondary Cancer (Metastasis) to the Thyroid and Advances in Management. Int J Mol Sci. 2022;23. doi: 10.3390\/ijms23063242","DOI":"10.3390\/ijms23063242"},{"key":"ref5","doi-asserted-by":"publisher","unstructured":"6. Nixon IJ, Coca-Pelaz A, Kaleva AI, Triantafyllou A, Angelos P, Owen RP, Rinaldo A, Shaha AR, Silver CE, Ferlito A. Metastasis to the Thyroid Gland: A Critical Review. Ann Surg Oncol. 2017;24: 1533-1539. doi: 10.1245\/s10434-016-5683-4","DOI":"10.1245\/s10434-016-5683-4"},{"key":"ref6","doi-asserted-by":"publisher","unstructured":"7. Song OK, Koo JS, Kwak JY, Moon HJ, Yoon JH, Kim E-K. Metastatic renal cell carcinoma in the thyroid gland: ultrasonographic features and the diagnostic role of core needle biopsy. Ultrasonography. 2017;36: 252-259. doi: 10.14366\/usg.16037","DOI":"10.14366\/usg.16037"},{"key":"ref7","doi-asserted-by":"publisher","unstructured":"8. Adamczewski Z, Dedecjus M, Skowro\u0144ska-J\u00f3\u017awiak E, Lewi\u0144ski A. Metastases of renal clear\u2011cell carcinoma to the thyroid: a comparison of shear\u2011wave and quasi\u2011static elastography. Pol Arch Med Wewn. 2014;124: 485-486. doi: 10.20452\/pamw.2413","DOI":"10.20452\/pamw.2413"},{"key":"ref8","doi-asserted-by":"publisher","unstructured":"9. Andrioli M, Persani L. Elastographic presentation of synchronous renal cell carcinoma metastasis to the thyroid gland. Endocrine. 2014;47: 336-337. doi: 10.1007\/s12020-013-0124-7","DOI":"10.1007\/s12020-013-0124-7"},{"key":"ref9","doi-asserted-by":"publisher","unstructured":"10. Iadarola C, Croce L, Quaquarini E, Teragni C, Pinto S, Bernardo A, Fonte R, Marin\u00f2 M, Rotondi M, Chiovato L. Nivolumab Induced Thyroid Dysfunction: Unusual Clinical Presentation and Challenging Diagnosis. Front Endocrinol (Lausanne). 2019 Jan 17;9:813. doi: 10.3389\/fendo.2018.00813.","DOI":"10.3389\/fendo.2018.00813"},{"key":"ref10","doi-asserted-by":"publisher","unstructured":"11. Ahmadieh H, Salti I. Tyrosine kinase inhibitors induced thyroid dysfunction: a review of its incidence, pathophysiology, clinical relevance, and treatment. Biomed Res Int. 2013;2013: 725410. doi:: 10.1155\/2013\/725410","DOI":"10.1155\/2013\/725410"},{"key":"ref11","doi-asserted-by":"publisher","unstructured":"12. Beutner U, Leowardi C, Bork U, L\u00fcthi C, Tarantino I, Pahernik S, et al. Survival after renal cell carcinoma metastasis to the thyroid: single center experience and systematic review of the literature. Thyroid. 2015;25: 314-324. doi:: 10.1089\/thy.2014.0498","DOI":"10.1089\/thy.2014.0498"}],"container-title":["Revista de la Facultad de Ciencias M\u00e9dicas de C\u00f3rdoba"],"original-title":[],"link":[{"URL":"http:\/\/revistas.unc.edu.ar\/index.php\/med\/article\/download\/45462\/49438","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/revistas.unc.edu.ar\/index.php\/med\/article\/download\/45462\/49395","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/revistas.unc.edu.ar\/index.php\/med\/article\/download\/45462\/49395","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,6,26]],"date-time":"2025-06-26T16:38:03Z","timestamp":1750955883000},"score":1,"resource":{"primary":{"URL":"http:\/\/revistas.unc.edu.ar\/index.php\/med\/article\/view\/45462"}},"subtitle":["reporte de un caso","case report","relato de caso"],"short-title":[],"issued":{"date-parts":[[2025,6,26]]},"references-count":12,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2025,6,26]]}},"URL":"https:\/\/doi.org\/10.31053\/1853.0605.v82.n2.45462","relation":{},"ISSN":["1853-0605","0014-6722"],"issn-type":[{"value":"1853-0605","type":"electronic"},{"value":"0014-6722","type":"print"}],"subject":[],"published":{"date-parts":[[2025,6,26]]}}}