{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,3]],"date-time":"2026-07-03T19:15:47Z","timestamp":1783106147639,"version":"3.54.6"},"reference-count":8,"publisher":"Universidad Nacional de C\u00f3rdoba","issue":"2","license":[{"start":{"date-parts":[[2026,6,22]],"date-time":"2026-06-22T00:00:00Z","timestamp":1782086400000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Rev Fac Cien Med Univ Nac Cordoba"],"abstract":"<jats:p>Objetivo: Este estudio tiene como objetivo presentar un caso cl\u00ednico de Mieloma M\u00faltiple (MM) con una presentaci\u00f3n oral inusual, subrayando la importancia de la vigilancia bucal en el diagn\u00f3stico integral de enfermedades hematol\u00f3gicas.\nCaso Cl\u00ednico: Se presenta el caso de una paciente femenina de 70 a\u00f1os que acudi\u00f3 a la C\u00e1tedra de Estomatolog\u00eda \"A\" de la Facultad de Odontolog\u00eda de la Universidad Nacional de C\u00f3rdoba con lesiones gingivales bimaxilares de 6 meses de evoluci\u00f3n. La paciente, sin antecedentes patol\u00f3gicos conocidos, present\u00f3 p\u00e9rdida de peso significativa y s\u00edntomas sist\u00e9micos graves. Al examen cl\u00ednico, se observaron masas hiperpl\u00e1sicas gingivales dolorosas, con movilidad dental generalizada. La ortopantomograf\u00eda y la tomograf\u00eda revelaron reabsorci\u00f3n alveolar y \u00e1reas osteol\u00edticas. Los an\u00e1lisis de laboratorio mostraron anemia, leucopenia, trombocitopenia, y marcadores inflamatorios elevados. La biopsia revel\u00f3 una proliferaci\u00f3n de c\u00e9lulas plasm\u00e1ticas monoclonales positivas para CD38 y cadenas kappa, lo que llev\u00f3 al diagn\u00f3stico de MM. La paciente fue remitida a oncohematolog\u00eda, pero falleci\u00f3 r\u00e1pidamente.\nConclusi\u00f3n: Este caso destaca la importancia del reconocimiento temprano de manifestaciones orales de MM, que pueden ser un desaf\u00edo diagn\u00f3stico debido a su similitud con otras afecciones orales comunes. La identificaci\u00f3n oportuna de estas lesiones por parte de los odont\u00f3logos puede ser crucial para reducir la morbilidad y mortalidad asociadas a esta enfermedad hematol\u00f3gica.<\/jats:p>","DOI":"10.31053\/1853.0605.v83.n2.46439","type":"journal-article","created":{"date-parts":[[2026,6,30]],"date-time":"2026-06-30T19:01:06Z","timestamp":1782846066000},"page":"e46439","source":"Crossref","is-referenced-by-count":0,"title":["Hiperplasia gingingival generalizada como manifestaci\u00f3n tard\u00eda de mieloma m\u00faltiple","Hiperplasia gengival generalizada como manifesta\u00e7\u00e3o tardia de Mieloma M\u00faltiplo","Generalized gingival hyperplasia as a late manifestation of multiple myeloma"],"prefix":"10.31053","volume":"83","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5201-1444","authenticated-orcid":false,"given":"Gerardo Marcelo","family":"Gilligan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-7263-1886","authenticated-orcid":false,"given":"Juan Cruz","family":"Romero Panico","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6427-1254","authenticated-orcid":false,"given":"Rene","family":"Panico","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"12333","published-online":{"date-parts":[[2026,6,22]]},"reference":[{"key":"ref0","doi-asserted-by":"publisher","unstructured":"1. Gerecke C, Fuhrmann S, Strifler S, Schmidt-Hieber M, Einsele H, Knop S. The Diagnosis and Treatment of Multiple Myeloma. Dtsch Arztebl Int. 2016 Jul 11;113(27-28):470-6. doi: 10.3238\/arztebl.2016.0470.","DOI":"10.3238\/arztebl.2016.0470"},{"key":"ref1","unstructured":"2. Huang JS, Ho YP, Ho KY, Wu YM, Chen CC, Wang CC, Tsai CC, Lin SF. [Multiple myeloma with oral manifestations--report of two cases]. Kaohsiung J Med Sci. 1997 Jun;13(6):388-94"},{"key":"ref2","doi-asserted-by":"publisher","unstructured":"3. Jain S, Kaur H, Kansal G, Gupta P. Multiple myeloma presenting as gingival hyperplasia. J Indian Soc Periodontol. 2013 May;17(3):391-3. doi: 10.4103\/0972-124X.115652.","DOI":"10.4103\/0972-124X.115652"},{"key":"ref3","unstructured":"4. Neville B. W, Damm, DD, Allen CM, Chi AC. Oral and Maxillofacial Pathology. 4th ed. Elsevier, St. Louis, 2016."},{"key":"ref4","doi-asserted-by":"publisher","unstructured":"5. Padala SA, Barsouk A, Barsouk A, Rawla P, Vakiti A, Kolhe R, Kota V, Ajebo GH. Epidemiology, Staging, and Management of Multiple Myeloma. Med Sci (Basel). 2021 Jan 20;9(1):3. doi: 10.3390\/medsci9010003.","DOI":"10.3390\/medsci9010003"},{"key":"ref5","doi-asserted-by":"publisher","unstructured":"6. Furutani M, Ohnishi M, Tanaka Y. Mandibular involvement in patients with multiple myeloma. J Oral Maxillofac Surg. 1994 Jan;52(1):23-5. doi: 10.1016\/0278-2391(94)90007-8.","DOI":"10.1016\/0278-2391(94)90007-8"},{"key":"ref6","doi-asserted-by":"publisher","unstructured":"7. Pisano JJ, Coupland R, Chen SY, Miller AS. Plasmacytoma of the oral cavity and jaws: a clinicopathologic study of 13 cases. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 1997 Feb;83(2):265-71. doi: 10.1016\/s1079-2104(97)90015-9.","DOI":"10.1016\/S1079-2104(97)90015-9"},{"key":"ref7","doi-asserted-by":"publisher","unstructured":"8. Lee SH, Huang JJ, Pan WL, Chan CP. Gingival mass as the primary manifestation of multiple myeloma: report of two cases. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 1996 Jul;82(1):75-9. doi: 10.1016\/s1079-2104(96)80380-5. Erratum in: Oral Surg Oral Med Oral Pathol Oral Radiol Endod 1996 Nov;82(5):516.","DOI":"10.1016\/S1079-2104(96)80380-5"}],"container-title":["Revista de la Facultad de Ciencias M\u00e9dicas de C\u00f3rdoba"],"original-title":[],"link":[{"URL":"http:\/\/revistas.unc.edu.ar\/index.php\/med\/article\/download\/46439\/54047","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/revistas.unc.edu.ar\/index.php\/med\/article\/download\/46439\/54049","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/revistas.unc.edu.ar\/index.php\/med\/article\/download\/46439\/54047","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,3]],"date-time":"2026-07-03T18:19:46Z","timestamp":1783102786000},"score":1,"resource":{"primary":{"URL":"http:\/\/revistas.unc.edu.ar\/index.php\/med\/article\/view\/46439"}},"subtitle":["reporte de un caso","relato de caso","a case report"],"short-title":[],"issued":{"date-parts":[[2026,6,22]]},"references-count":8,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2026,6,30]]}},"URL":"https:\/\/doi.org\/10.31053\/1853.0605.v83.n2.46439","relation":{},"ISSN":["1853-0605","0014-6722"],"issn-type":[{"value":"1853-0605","type":"electronic"},{"value":"0014-6722","type":"print"}],"subject":[],"published":{"date-parts":[[2026,6,22]]}}}