{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,3]],"date-time":"2026-07-03T18:22:48Z","timestamp":1783102968167,"version":"3.54.6"},"reference-count":10,"publisher":"Universidad Nacional de C\u00f3rdoba","issue":"2","license":[{"start":{"date-parts":[[2026,5,20]],"date-time":"2026-05-20T00:00:00Z","timestamp":1779235200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Rev Fac Cien Med Univ Nac Cordoba"],"abstract":"<jats:p>La enfermedad injerto contra hu\u00e9sped (EICH) cut\u00e1nea es una complicaci\u00f3n potencialmente grave tras trasplante alog\u00e9nico de c\u00e9lulas progenitoras hematopoy\u00e9ticas. Presentamos el caso de una mujer de 40 a\u00f1os con leucemia mieloide aguda, que se realiz\u00f3 un trasplante alog\u00e9nico con donante no relacionado HLA compatible. Durante la fase postrasplante desarroll\u00f3 EICH cut\u00e1nea refractaria a corticoides, progresando a lesiones generalizadas compatibles con necrolisis epid\u00e9rmica t\u00f3xica (NET-like). El manejo incluy\u00f3 terapias de segunda y tercera l\u00ednea, como inhibidores de JAK (ruxolitinib), inmunoglobulina, agentes biol\u00f3gicos (infliximab, rituximab) y procedimientos extracorp\u00f3reos (fotof\u00e9resis y plasmaf\u00e9resis). La intervenci\u00f3n temprana y la coordinaci\u00f3n de un equipo multidisciplinario permitieron el control de la enfermedad y la mejor\u00eda progresiva de las lesiones. Este caso enfatiza la importancia del reconocimiento precoz de la EICH cut\u00e1nea grave, la adaptaci\u00f3n del tratamiento seg\u00fan la gravedad y la respuesta cl\u00ednica, y la necesidad de un abordaje multidisciplinario para reducir la morbimortalidad.<\/jats:p>","DOI":"10.31053\/1853.0605.v83.n2.50076","type":"journal-article","created":{"date-parts":[[2026,6,30]],"date-time":"2026-06-30T19:03:17Z","timestamp":1782846197000},"page":"e50076","source":"Crossref","is-referenced-by-count":0,"title":["Enfermedad injerto contra hu\u00e9sped cut\u00e1nea refractaria a corticoides","Steroid-Refractory Cutaneous Graft-versus-Host Disease","Doen\u00e7a Cut\u00e2nea do Enxerto contra o Hospedeiro Refrat\u00e1ria a Corticosteroides"],"prefix":"10.31053","volume":"83","author":[{"given":"Sabrina","family":"Appeceix","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-3167-1396","authenticated-orcid":false,"given":"Gabriel","family":"Vicente","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Florencia","family":"Comacchio","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lucas","family":"Fernandez Otero","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"12333","published-online":{"date-parts":[[2026,5,20]]},"reference":[{"key":"ref0","doi-asserted-by":"publisher","unstructured":"1. Sureda A, Corbacioglu S, Greco R, Kr\u00f6ger N, Carreras E, editors. The EBMT Handbook: Hematopoietic Cell Transplantation and Cellular Therapies [Internet]. 8th ed. Cham (CH): Springer; 2024","DOI":"10.1007\/978-3-031-44080-9"},{"key":"ref1","doi-asserted-by":"publisher","unstructured":"2. Shi CR, Ferreira AL, Kaur M, Xiang D, Caputo J, Choe HK, Hamad N, Cowen EW, Kaffenberger BH, Baumrin E. Cutaneous Chronic Graft-Versus-Host Disease: Clinical Manifestations, Diagnosis, Management, and Supportive Care. Transplant Cell Ther. 2024 Sep;30(9S):S513-S533. doi: 10.1016\/j.jtct.2024.05.020.","DOI":"10.1016\/j.jtct.2024.05.020"},{"key":"ref2","doi-asserted-by":"publisher","unstructured":"3. Holler E, Greinix H, Zeiser R. Acute Graft-Versus-Host Disease. 2024 Apr 11. En: Sureda A, Corbacioglu S, Greco R, Kr\u00f6ger N, Carreras E, editors. The EBMT Handbook: Hematopoietic Cell Transplantation and Cellular Therapies [Internet]. 8th ed. Cham (CH): Springer; 2024. Chapter 43.","DOI":"10.1007\/978-3-031-44080-9_43"},{"key":"ref3","doi-asserted-by":"publisher","unstructured":"4. Zeiser R, von Bubnoff N, Butler J, Mohty M, Niederwieser D, Or R, Szer J, Wagner EM, Zuckerman T, Mahuzier B, Xu J, Wilke C, Gandhi KK, Soci\u00e9 G; REACH2 Trial Group. Ruxolitinib for Glucocorticoid-Refractory Acute Graft-versus-Host Disease. N Engl J Med. 2020 May 7;382(19):1800-1810. doi: 10.1056\/NEJMoa1917635.","DOI":"10.1056\/NEJMoa1917635"},{"key":"ref4","doi-asserted-by":"publisher","unstructured":"5. Newell LF, Holtan SG. Acute GVHD: think before you treat. Hematology Am Soc Hematol Educ Program. 2021 Dec 10;2021(1):642-647. doi: 10.1182\/hematology.2021000300.","DOI":"10.1182\/hematology.2021000300"},{"key":"ref5","doi-asserted-by":"publisher","unstructured":"6. Hung YT, Chen YW, Huang Y, Lin YJ, Chen CB, Chung WH. Acute graft-versus-host disease presenting as Stevens-Johnson syndrome and toxic epidermal necrolysis: A retrospective cohort study. J Am Acad Dermatol. 2023 Apr;88(4):792-801. doi: 10.1016\/j.jaad.2022.10.035.","DOI":"10.1016\/j.jaad.2022.10.035"},{"key":"ref6","doi-asserted-by":"publisher","unstructured":"7. Macedo FI, Faris J, Lum LG, Gabali A, Uberti JP, Ratanatharathorn V, White MT. Extensive toxic epidermal necrolysis versus acute graft versus host disease after allogenic hematopoietic stem-cell transplantation: challenges in diagnosis and management. J Burn Care Res. 2014 Nov-Dec;35(6):e431-5. doi: 10.1097\/BCR.0000000000000040.","DOI":"10.1097\/BCR.0000000000000040"},{"key":"ref7","doi-asserted-by":"publisher","unstructured":"8. Mahmoudjafari Z, Bhatt V, Galvin J, Xue Z, Zeiser R, Locatelli F, Soci\u00e9 G, Mohty M. Impact of cytopenias and early versus late treatment with ruxolitinib in patients with steroid-refractory acute or chronic graft-versus-host disease. Bone Marrow Transplant. 2025 Jan;60(1):69-78. doi: 10.1038\/s41409-024-02445-6.","DOI":"10.1038\/s41409-024-02445-6"},{"key":"ref8","doi-asserted-by":"publisher","unstructured":"9. Patel DA, Crain M, Pusic I, Schroeder MA. Acute Graft-versus-Host Disease: An Update on New Treatment Options. Drugs. 2023 Jul;83(10):893-907. doi: 10.1007\/s40265-023-01889-2.","DOI":"10.1007\/s40265-023-01889-2"},{"key":"ref9","doi-asserted-by":"publisher","unstructured":"10. Lozano M, Charry P, de Pablo-Mir\u00f3 M, Salas MQ, Mart\u00ednez C, Su\u00e1rez-Lled\u00f3 M, Fern\u00e1ndez-Avil\u00e9s F, Rovira M, Cid J. Role of extracorporeal photopheresis in the management of acute and chronic graft versus disease: current status. 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