{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,2]],"date-time":"2026-05-02T12:43:39Z","timestamp":1777725819639,"version":"3.51.4"},"reference-count":36,"publisher":"IMR Press","issue":"2","license":[{"start":{"date-parts":[[2026,3,24]],"date-time":"2026-03-24T00:00:00Z","timestamp":1774310400000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100017959","name":"Hebei Provincial Health Commission","doi-asserted-by":"crossref","award":["20220776"],"award-info":[{"award-number":["20220776"]}],"id":[{"id":"10.13039\/100017959","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Alpha Psychiatry"],"abstract":"<jats:p>Background: Autism spectrum disorder (ASD) is a neurodevelopmental condition characterized by deficits in social communication and repetitive behaviors. Early identification of high-risk infants is crucial for intervention and long-term outcomes. This study explored the association between early neurological development from 12 to 15 months and the related risk factors for ASD, with a primary focus on M-CHAT status at 24 months as the screening outcome, and the impact of family history, prematurity, and sleep disorders. Methods: We conducted a retrospective analysis of 50 children aged 24 months who tested positive on the Modified Checklist for Autism in Toddlers (M-CHAT) and 50 matched controls with negative results. Neurodevelopmental status was assessed using the Gesell Developmental Diagnosis Scale (GDDS), the Peabody Developmental Motor Scales, Second Edition (PDMS-2), and the Sensory Integration Schedule (SIS). Statistical analyses, including logistic regression, were used to evaluate associations among baseline characteristics, neurodevelopmental scores, and ASD risk factors. Results: A total of 100 infants were included, with 50 classified as high risk and 50 as low risk. High-risk infants had significantly higher rates of family history of ASD, prematurity, and sleep disorders. They showed impairments across several PDMS-2 subscales, including stationary, locomotion, and grasping, as well as GDDS subscales such as adaptability and language. Logistic regression analysis revealed that neurodevelopmental impairments were significantly associated with M-CHAT positivity at 24 months. Conclusions: Early neurodevelopmental impairments in infants aged 12 to 15 months may serve as important indicators of ASD risk. Identifying these factors may facilitate timely intervention and improve outcomes for high-risk children.<\/jats:p>","DOI":"10.31083\/ap42936","type":"journal-article","created":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T10:41:17Z","timestamp":1777459277000},"source":"Crossref","is-referenced-by-count":0,"title":["Early Assessment of Neurodevelopmental Scales Correlates With Positive M-CHAT Screening in 24-Month-Old Infants"],"prefix":"10.31083","volume":"27","author":[{"ORCID":"https:\/\/orcid.org\/0009-0007-8647-1098","authenticated-orcid":true,"given":"Haixia","family":"Chang","sequence":"first","affiliation":[{"name":"Pediatric Health Care Department & Psychological Behavior Department, Hebei Children's Hospital, 050031 Shijiazhuang, Hebei, China"},{"name":"Hebei Provincial Clinical Research Center for Child Health and Disease, 050031 Shijiazhuang, Hebei, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-6226-5393","authenticated-orcid":true,"given":"Yali","family":"Liu","sequence":"additional","affiliation":[{"name":"Pediatric Health Care Department & Psychological Behavior Department, Hebei Children's Hospital, 050031 Shijiazhuang, Hebei, China"},{"name":"Hebei Provincial Clinical Research Center for Child Health and Disease, 050031 Shijiazhuang, Hebei, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-5777-6905","authenticated-orcid":true,"given":"Jinfang","family":"Lv","sequence":"additional","affiliation":[{"name":"Pediatric Health Care Department & Psychological Behavior Department, Hebei Children's Hospital, 050031 Shijiazhuang, Hebei, China"},{"name":"Hebei Provincial Clinical Research Center for Child Health and Disease, 050031 Shijiazhuang, Hebei, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-3674-8667","authenticated-orcid":true,"given":"Qin","family":"Li","sequence":"additional","affiliation":[{"name":"Hebei Provincial Clinical Research Center for Child Health and Disease, 050031 Shijiazhuang, Hebei, China"},{"name":"Department of Respiratory Medicine, Hebei Children's Hospital, 050031 Shijiazhuang, Hebei, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-0574-0538","authenticated-orcid":true,"given":"Junqiang","family":"Xue","sequence":"additional","affiliation":[{"name":"Department of Vascular Surgery, Shijiazhuang People's Hospital, 050000 Shijiazhuang, Hebei, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-8793-6232","authenticated-orcid":true,"given":"Xia","family":"Wang","sequence":"additional","affiliation":[{"name":"Pediatric Health Care Department & Psychological Behavior Department, Hebei Children's Hospital, 050031 Shijiazhuang, Hebei, China"},{"name":"Hebei Provincial Clinical Research Center for Child Health and Disease, 050031 Shijiazhuang, Hebei, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"16242","published-online":{"date-parts":[[2026,3,24]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","unstructured":"Sharma SR, Gonda X, Tarazi FI. 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