{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,13]],"date-time":"2026-08-13T08:28:58Z","timestamp":1786609738345,"version":"build-2736575974"},"reference-count":113,"publisher":"IMR Press","issue":"3","license":[{"start":{"date-parts":[[2026,6,29]],"date-time":"2026-06-29T00:00:00Z","timestamp":1782691200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"UK Research and Innovation [UKRI] award","award":["MR\/W002183\/1"],"award-info":[{"award-number":["MR\/W002183\/1"]}]},{"name":"Medical Research Council","award":["MC_U130015185"],"award-info":[{"award-number":["MC_U130015185"]}]},{"name":"Medical Research Council","award":["MC_UU_12017\/1"],"award-info":[{"award-number":["MC_UU_12017\/1"]}]},{"name":"Medical Research Council","award":["MC_UU_12017\/13"],"award-info":[{"award-number":["MC_UU_12017\/13"]}]},{"name":"North Central London Consortium"},{"name":"Primary Care Research Network"},{"DOI":"10.13039\/501100013529","name":"National Lottery Community Fund","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100013529","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Alpha Psychiatry"],"abstract":"<jats:p>Background:Evidence on the impact of adverse childhood experiences (ACEs) on multidimensional wellbeing, including health-related quality of life (HRQoL) and quality-adjusted life-years (QALYs), remains inadequate, particularly among young people. This study examines how ACEs and their interactions with sex, ethnicity, and socioeconomic status (SES) are associated with HRQoL and QALYs in United Kingdom (UK) adolescents.Methods:Baseline and follow-up data from the Determinants of Adolescent Social Well-being and Health (DASH) Study (N = 6648) and HeadStart Cornwall (HeadStart) (N = 4575) were used. ACE data were sourced from self-reports and official records and measured as binary and count variables. The Strengths and Difficulties Questionnaire (SDQ) was mapped to the Child Health Utility 9D (CHU9D) to calculate utility values for QALY estimation.Results: Over the 3- and 2-year follow-up periods, mean accumulated QALYs were 2.30 (standard error [SE]: 0.002) (DASH) and 1.45 (SE: 0.004) (HeadStart). The occurrence of any ACEs, self-reported and officially recorded, respectively, reduced QALYs by 0.064 (SE: 0.021) (DASH) and 0.060 (SE: 0.021) (HeadStart). These translate to losses of 23 (DASH) and 22 (HeadStart) days over the follow-up period. A greater count of ACEs was associated with stronger effects. Dose-dependent interactions were significant only for ACEs-ethnicity and ACEs-sex (\u22652 ACEs), with White adolescents and females experiencing greater QALY losses as the number of ACEs increased.Conclusions:ACEs, whether self-reported or officially recorded, were associated with greater QALY losses, with the strength of association increasing as the number of ACEs increased. Furthermore, White and female adolescents exposed to a greater number of ACEs had the highest QALY losses. Further studies are needed to investigate the moderation of these associations and the mechanisms underlying the associations between ACEs and HRQoL\/QALYs to inform targeted interventions.<\/jats:p>","DOI":"10.31083\/ap49284","type":"journal-article","created":{"date-parts":[[2026,7,7]],"date-time":"2026-07-07T12:42:51Z","timestamp":1783428171000},"source":"Crossref","is-referenced-by-count":2,"title":["Association of Adverse Childhood Experiences With Health-Related Quality of Life and Quality-Adjusted Life-Years Among Adolescents in the United Kingdom: Findings From Two General Population Cohorts"],"prefix":"10.31083","volume":"27","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4299-9559","authenticated-orcid":true,"given":"Amarech","family":"Obse","sequence":"first","affiliation":[{"name":"The Institute for Lifecourse Development, University of Greenwich, Old Royal Naval College, Park Row, SE10 9LS London, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kamaldeep","family":"Bhui","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, Nuffield Department of Primary Care Health Sciences, and Wadham College, University of Oxford, OX3 7JX Oxford, UK"},{"name":"Oxford Health, Oxford and East London NHS Foundation Trusts, OX4 4XN London, UK"},{"name":"World Psychiatric Association Collaborating Centre, OX3 7JX Oxford, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura","family":"Havers","sequence":"additional","affiliation":[{"name":"Centre for Psychiatry and Mental Health, Wolfson Institute of Population Health, Queen Mary, University of London, E1 4NS London, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sania","family":"Shakoor","sequence":"additional","affiliation":[{"name":"Centre for Psychiatry and Mental Health, Wolfson Institute of Population Health, Queen Mary, University of London, E1 4NS London, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Georgina","family":"Hosang","sequence":"additional","affiliation":[{"name":"Centre for Psychiatry and Mental Health, Wolfson Institute of Population Health, Queen Mary, University of London, E1 4NS London, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Siobhan","family":"Hugh-Jones","sequence":"additional","affiliation":[{"name":"School of Psychology, University of Leeds, LS2 9JT Leeds, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Minhua","family":"Ma","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, University of Oxford, OX3 7JX Oxford, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"Mankee-Williams","sequence":"additional","affiliation":[{"name":"Research and Innovation Department, Falmouth University, TR10 9FE Falmouth, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexis","family":"Karamanos","sequence":"additional","affiliation":[{"name":"Department of Population Health Sciences, School of Life Course & Population Sciences, Faculty of Life Sciences and Medicine, King\u2019s College London, SE1 1UL London, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seeromanie","family":"Harding","sequence":"additional","affiliation":[{"name":"Department of Population Health Sciences, School of Life Course & Population Sciences, Faculty of Life Sciences and Medicine, King\u2019s College London, SE1 1UL London, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul","family":"McCrone","sequence":"additional","affiliation":[{"name":"The Institute for Lifecourse Development, University of Greenwich, Old Royal Naval College, Park Row, SE10 9LS London, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"16242","published-online":{"date-parts":[[2026,6,29]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","unstructured":"Felitti VJ, Anda RF, Nordenberg D, Williamson DF, Spitz AM, Edwards V, et al. 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