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This review offers a practical overview of the principles, core techniques, and contemporary evidence for implementing OSA and OFA within routine hospital anaesthesia practice. Central to OSA\/OFA is the integration of multimodal analgesia, which includes regional anaesthetic blocks, alpha-2 agonists, N-methyl-D-aspartate (NMDA) receptor antagonists, and gabapentinoids. Key advantages include reduced postoperative nausea and vomiting (PONV), faster return of bowel function, and markedly decreased opioid requirements. Effective implementation requires comprehensive patient education, individualized perioperative protocols, and coordinated interdisciplinary teamwork. OSA and OFA represent safe, effective, and increasingly essential strategies for perioperative pain management. Their broader integration can improve patient recovery outcomes, reduce opioid-related complications, and contribute to institutional medication-safety initiatives.<\/jats:p>","DOI":"10.31083\/bjhm54057","type":"journal-article","created":{"date-parts":[[2026,5,30]],"date-time":"2026-05-30T08:09:42Z","timestamp":1780128582000},"source":"Crossref","is-referenced-by-count":1,"title":["Opioid-Sparing and Opioid-Free Anaesthesia: A Review of Clinical Evidence and Implementation Considerations"],"prefix":"10.31083","volume":"87","author":[{"ORCID":"https:\/\/orcid.org\/0009-0007-8936-5442","authenticated-orcid":true,"given":"Qiushi","family":"Zhang","sequence":"first","affiliation":[{"name":"Department of Anesthesiology, Tianyou Hospital Affiliated to Wuhan University of Science and Technology, 430064 Wuhan, Hubei, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yao","family":"Ma","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology, Tianyou Hospital Affiliated to Wuhan University of Science and Technology, 430064 Wuhan, Hubei, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiali","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology, Tianyou Hospital Affiliated to Wuhan University of Science and Technology, 430064 Wuhan, Hubei, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huan","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology, Tianyou Hospital Affiliated to Wuhan University of Science and Technology, 430064 Wuhan, Hubei, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"16242","published-online":{"date-parts":[[2026,5,20]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","unstructured":"Gnielinski M, Adams HA. 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