{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,7]],"date-time":"2026-07-07T11:18:57Z","timestamp":1783423137472,"version":"3.54.6"},"reference-count":23,"publisher":"IMR Press","issue":"6","license":[{"start":{"date-parts":[[2026,6,15]],"date-time":"2026-06-15T00:00:00Z","timestamp":1781481600000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Br. J. Hosp. Med. (Lond)"],"abstract":"<jats:p>Aims\/Background: Food protein-induced allergic proctocolitis (FPIAP) is a common allergic disease in the clinic. Despite being the diagnostic gold-standard method, the avoidance-provocation test has certain limitations that hinder its clinical applications. Detection of peripheral blood cells has emerged as an important research hotspot because of its relative methodological simplicity. Platelets and eosinophils play an important role in allergic diseases, but relevant studies on newborns with FPIAP remain scarce. The purpose of this study was to investigate the changes of eosinophil and platelet levels in children with allergic enteritis, and to explore its application value in the differential diagnosis of newborns with FPIAP. Methods: This retrospective study included 41 newborns with FPIAP admitted to The Affiliated Yangming Hospital of Ningbo University from December 2022 to December 2024 and 80 healthy newborns who underwent physical examination during the same period as controls. Data of all selected newborns and their mothers were collected from their medical records. The morning venous blood samples of the two groups were collected. White blood cell count, neutrophils, lymphocytes, monocytes, eosinophils, basophils, platelets and hemoglobin were detected using an automatic blood cell analyzer. Logistic regression analysis was used to analyze the risk factors of newborns with FPIAP. Receiver operating characteristic (ROC) curve was used to analyze the diagnostic value of these blood parameters for newborns with FPIAP. Results: The results showed that eosinophils and platelets in the FPIAP group were significantly higher than those in the control group (p &lt; 0.05). Logistic regression analysis showed that elevated levels of eosinophils and platelets were risk factors for newborns with FPIAP (p &lt; 0.05). The combined detection of peripheral blood platelet and eosinophil counts yielded an area under the ROC curve of 0.862 for the diagnosis of FPIAP in newborns, with a specificity of 0.825 and a sensitivity of 0.805. Conclusion: Newborns with FPIAP feature increased eosinophil and platelet counts, which provide an invaluable diagnostic reference for the allergic disease when used in combination.<\/jats:p>","DOI":"10.31083\/bjhm54903","type":"journal-article","created":{"date-parts":[[2026,7,7]],"date-time":"2026-07-07T10:55:28Z","timestamp":1783421728000},"source":"Crossref","is-referenced-by-count":0,"title":["Diagnostic Utility of Eosinophil and Platelet in Newborns With Food Protein-Induced Allergic Proctocolitis: A Retrospective Study"],"prefix":"10.31083","volume":"87","author":[{"ORCID":"https:\/\/orcid.org\/0009-0008-6487-3173","authenticated-orcid":true,"given":"Fengwei","family":"Chu","sequence":"first","affiliation":[{"name":"Department of Pediatrics, The Affiliated Yangming Hospital of Ningbo University, 315400 Ningbo, Zhejiang, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qing","family":"Ye","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, The Affiliated Yangming Hospital of Ningbo University, 315400 Ningbo, Zhejiang, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"16242","published-online":{"date-parts":[[2026,6,15]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","unstructured":"Giannetti A, Toschi Vespasiani G, Ricci G, Miniaci A, di Palmo E, Pession A. 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