{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,7]],"date-time":"2026-07-07T11:18:31Z","timestamp":1783423111867,"version":"3.54.6"},"reference-count":35,"publisher":"IMR Press","issue":"6","license":[{"start":{"date-parts":[[2026,6,22]],"date-time":"2026-06-22T00:00:00Z","timestamp":1782086400000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Guizhou Provincial Science and Technology Foundation Project","award":["gzwkj2023-402"],"award-info":[{"award-number":["gzwkj2023-402"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Br. J. Hosp. Med. (Lond)"],"abstract":"<jats:p>Aims\/Background: Oxaliplatin-induced peripheral neuropathy (OIPN) is a common dose-limiting toxic effect of oxaliplatin-based chemotherapy for colorectal cancer (CRC), severely affecting patients\u2019 quality of life and treatment adherence. Currently, effective therapeutic options for OIPN are limited. This study aimed to investigate the clinical efficacy and safety of sodium ferulate combined with methylcobalamin in the treatment of OIPN in CRC patients. Methods: In this retrospective cohort study, 280 CRC patients diagnosed with OIPN following oxaliplatin-based chemotherapy at Qianxi People\u2019s Hospital between January 2020 and December 2024 were enrolled. Based on treatment regimen, patients were assigned to an observation group (sodium ferulate combined with methylcobalamin, n = 152) or a control group (methylcobalamin alone, n = 128). All patients received basic nursing care. Treatment duration was 8 weeks for both groups. Outcomes compared between groups included National Cancer Institute Common Terminology Criteria for Adverse Events (NCI-CTCAE) neurotoxicity grading, nerve conduction velocity (NCV), and quality of life (QoL) scores assessed before treatment, at 4 weeks, and at 8 weeks post-treatment. Clinical efficacy was evaluated after 8 weeks, and changes in hematological parameters and liver\/kidney function indicators were monitored. Results: Baseline characteristics were comparable between the two groups (p &gt; 0.05). While no significant difference in neurotoxicity grading was observed at 4 weeks (p &gt; 0.05), the observation group demonstrated significantly better NCI-CTCAE grades than the control group at 8 weeks (p &lt; 0.05). NCV assessments revealed that motor and sensory NCVs of the median and common peroneal nerves in the observation group were significantly improved compared to both baseline levels and the control group at 4 and 8 weeks (p &lt; 0.05). After 8 weeks, the overall clinical efficacy rate was significantly higher in the observation group (89.47%) than in the control group (67.97%) (p &lt; 0.05). QoL scores across all functional domains (physical, role, cognitive, emotional, and social) were significantly better in the observation group compared to the control group at 8 weeks (p &lt; 0.05). Hematological and liver\/kidney function parameters remained within normal ranges and showed no significant intergroup differences post-treatment (p &gt; 0.05). Conclusion: The combination of sodium ferulate and methylcobalamin is superior to methylcobalamin monotherapy in alleviating the severity of neurotoxicity, improving nerve conduction function, enhancing clinical efficacy, and promoting quality of life in CRC patients with OIPN, with a comparable safety profile. It represents a promising clinical treatment option for OIPN.<\/jats:p>","DOI":"10.31083\/bjhm55138","type":"journal-article","created":{"date-parts":[[2026,7,7]],"date-time":"2026-07-07T10:55:28Z","timestamp":1783421728000},"source":"Crossref","is-referenced-by-count":0,"title":["A Retrospective Comparative Study of Sodium Ferulate Combined With Methylcobalamin for Oxaliplatin-Induced Peripheral Neuropathy in Patients With Colorectal Cancer"],"prefix":"10.31083","volume":"87","author":[{"given":"Baojun","family":"Min","sequence":"first","affiliation":[{"name":"Department of Anesthesiology, Qianxi People\u2019s Hospital, 551599 Bijie, Guizhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Wan","sequence":"additional","affiliation":[{"name":"Department of Pain, Qianxi People\u2019s Hospital, 551599 Bijie, Guizhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongyong","family":"He","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology, Qianxi People\u2019s Hospital, 551599 Bijie, Guizhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jie","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology, Qianxi People\u2019s Hospital, 551599 Bijie, Guizhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhonglu","family":"Jian","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology, The First Affiliated Hospital of Guizhou University of Traditional Chinese Medicine, 550001 Guiyang, Guizhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-3339-7233","authenticated-orcid":true,"given":"Rong","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology, The First Affiliated Hospital of Guizhou University of Traditional Chinese Medicine, 550001 Guiyang, Guizhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"16242","published-online":{"date-parts":[[2026,6,22]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","unstructured":"Klimeck L, Heisser T, Hoffmeister M, Brenner H. Colorectal cancer: A health and economic problem. Best Practice & Research. Clinical Gastroenterology. 2023; 66: 101839.","DOI":"10.1016\/j.bpg.2023.101839"},{"key":"ref2","doi-asserted-by":"publisher","unstructured":"Roshandel G, Ghasemi-Kebria F, Malekzadeh R. Colorectal Cancer: Epidemiology, Risk Factors, and Prevention. Cancers. 2024; 16: 1530.","DOI":"10.3390\/cancers16081530"},{"key":"ref3","unstructured":"Soreide K, Berg M, Skudal BS, Nedreboe BS. Advances in the understanding and treatment of colorectal cancer. Discovery Medicine. 2011; 12: 393\u2013404."},{"key":"ref4","doi-asserted-by":"publisher","unstructured":"Sung H, Ferlay J, Siegel RL, Laversanne M, Soerjomataram I, Jemal A, et al. Global Cancer Statistics 2020: GLOBOCAN Estimates of Incidence and Mortality Worldwide for 36 Cancers in 185 Countries. CA: A Cancer Journal for Clinicians. 2021; 71: 209\u2013249.","DOI":"10.3322\/caac.21660"},{"key":"ref5","doi-asserted-by":"publisher","unstructured":"Zhou J, Zheng R, Zhang S, Zeng H, Wang S, Chen R, et al. Colorectal cancer burden and trends: Comparison between China and major burden countries in the world. Chinese Journal of Cancer Research. 2021; 33: 1\u201310.","DOI":"10.21147\/j.issn.1000-9604.2021.01.01"},{"key":"ref6","doi-asserted-by":"publisher","unstructured":"Cao W, Chen HD, Yu YW, Li N, Chen WQ. Changing profiles of cancer burden worldwide and in China: a secondary analysis of the global cancer statistics 2020. Chinese Medical Journal. 2021; 134: 783\u2013791.","DOI":"10.1097\/CM9.0000000000001474"},{"key":"ref7","doi-asserted-by":"publisher","unstructured":"Kuang Z, Wang J, Liu K, Wu J, Li J. Optimal duration of oxaliplatin-based adjuvant chemotherapy in patients with different risk factors for stage II-III colon cancer: a meta-analysis. International Journal of Surgery. 2024; 110: 3030\u20133038.","DOI":"10.1097\/JS9.0000000000001175"},{"key":"ref8","doi-asserted-by":"publisher","unstructured":"Nazari R, Piozzi GN, Ghalehtaki R, Ahmadi-Tafti SM, Behboudi B, Mousavi Darzikolaee N, et al. Role of Oxaliplatin in the Neoadjuvant Concurrent Chemoradiotherapy in Locally Advanced Rectal Cancer: a Review of Evidence. Clinical Medicine Insights. Oncology. 2024; 18: 11795549241236409.","DOI":"10.1177\/11795549241236409"},{"key":"ref9","doi-asserted-by":"publisher","unstructured":"Lucaciu RL, Hangan AC, Sevastre B, Oprean LS. Metallo-Drugs in Cancer Therapy: Past, Present and Future. Molecules. 2022; 27: 6485.","DOI":"10.3390\/molecules27196485"},{"key":"ref10","doi-asserted-by":"publisher","unstructured":"Lopez-Sanchez A, Bertrand HC. Pt (iv) anticancer prodrugs bearing an oxaliplatin scaffold: What do we know about their bioactivity? Inorganic Chemistry Frontiers. 2024; 11: 1639\u20131667.","DOI":"10.1039\/D3QI02602G"},{"key":"ref11","doi-asserted-by":"publisher","unstructured":"Manavi MA, Fathian Nasab MH, Mohammad Jafari R, Dehpour AR. Mechanisms underlying dose-limiting toxicities of conventional chemotherapeutic agents. Journal of Chemotherapy. 2024; 36: 623\u2013653.","DOI":"10.1080\/1120009X.2023.2300217"},{"key":"ref12","doi-asserted-by":"crossref","unstructured":"Mustafa MY, Khaled NA, Zeinab ME, Abd-El-Hakim M. Quality of life in colorectal cancer patients with oxaliplatin induced peripheral neuropathy. The Medical Journal of Cairo University. 2025; 93: 167\u2013178.","DOI":"10.21608\/mjcu.2025.422997"},{"key":"ref13","doi-asserted-by":"crossref","unstructured":"Justitia I, Dewi PK, Fauzi YR, Hunaifi I. Chemotherapy-induced peripheral neuropathy: Pathophysiology, diagnosis, and treatment. Chemotherapy. 2024; 4: 98\u2013106.","DOI":"10.20473\/aksona.v4i2.52071"},{"key":"ref14","doi-asserted-by":"crossref","unstructured":"Di Sibio A, Varrassi M, Venditti O, Di Cesare E, Romano L, Giuliani A, et al. A case of segmental hepatic necrosis complicating oxaliplatin and capecitabine chemotherapy A case report and review of the literature. Annali Italiani di Chirurgia. 2020; 9: S2239253X2003385X.","DOI":"10.1016\/j.ijscr.2019.07.001"},{"key":"ref15","doi-asserted-by":"publisher","unstructured":"Cheng F, Zhang RQ, Sun C, Ran Q, Zhang CH, Shen CH, et al. Oxaliplatin-induced peripheral neurotoxicity in colorectal cancer patients: mechanisms, pharmacokinetics and strategies. Frontiers in Pharmacology. 2023; 14: 1231401. https:\/\/doi.org\/1","DOI":"10.3389\/fphar.2023.1231401"},{"key":"ref16","doi-asserted-by":"publisher","unstructured":"Loprinzi CL, Lacchetti C, Bleeker J, Cavaletti G, Chauhan C, Hertz DL, et al. Prevention and Management of Chemotherapy-Induced Peripheral Neuropathy in Survivors of Adult Cancers: ASCO Guideline Update. Journal of Clinical Oncology. 2020; 38: 3325\u20133348.","DOI":"10.1200\/JCO.20.01399"},{"key":"ref17","doi-asserted-by":"publisher","unstructured":"Kawashiri T, Mine K, Kobayashi D, Inoue M, Ushio S, Uchida M, et al. Therapeutic Agents for Oxaliplatin-Induced Peripheral Neuropathy; Experimental and Clinical Evidence. International Journal of Molecular Sciences. 2021; 22: 1393.","DOI":"10.3390\/ijms22031393"},{"key":"ref18","doi-asserted-by":"publisher","unstructured":"Kang L, Tian Y, Xu S, Chen H. Oxaliplatin-induced peripheral neuropathy: clinical features, mechanisms, prevention and treatment. Journal of Neurology. 2021; 268: 3269\u20133282.","DOI":"10.1007\/s00415-020-09942-w"},{"key":"ref19","doi-asserted-by":"publisher","unstructured":"Alvarez-Mon MA, Garc\u00eda-Montero C, Fraile-Martinez O, Quintero J, Fernandez-Rojo S, Mora F, et al. Current Opinions about the Use of Duloxetine: Results from a Survey Aimed at Psychiatrists. Brain Sciences. 2023; 13: 333.","DOI":"10.3390\/brainsci13020333"},{"key":"ref20","unstructured":"H\u00f6ke A, Mi R. In search of novel treatments for peripheral neuropathies and nerve regeneration. Discovery Medicine. 2007; 7: 109\u2013112."},{"key":"ref21","doi-asserted-by":"publisher","unstructured":"Sambataro D, Scandurra G, Scarpello L, Gebbia V, Dominguez LJ, Valerio MR. A Practical Narrative Review on the Role of Magnesium in Cancer Therapy. Nutrients. 2025; 17: 2272.","DOI":"10.3390\/nu17142272"},{"key":"ref22","doi-asserted-by":"publisher","unstructured":"Li Y, Zheng J, Zhu Y, Qu Y, Suo R, Zhu Y. Neuroprotective effects of methylcobalamin in cerebral ischemia\/reperfusion injury through activation of the ERK1\/2 signaling pathway. International Immunopharmacology. 2021; 99: 108040.","DOI":"10.1016\/j.intimp.2021.108040"},{"key":"ref23","doi-asserted-by":"publisher","unstructured":"Ramadhani A, Astuti I, Widiastuti MG, Purwanti N. Methylcobalamin as a candidate for chronic peripheral neuropathic pain therapy: review of molecular pharmacology actiona. The Korean Journal of Pain. 2024; 37: 299\u2013309.","DOI":"10.3344\/kjp.24171"},{"key":"ref24","doi-asserted-by":"publisher","unstructured":"Li D, Rui YX, Guo SD, Luan F, Liu R, Zeng N. Ferulic acid: A review of its pharmacology, pharmacokinetics and derivatives. Life Sciences. 2021; 284: 119921.","DOI":"10.1016\/j.lfs.2021.119921"},{"key":"ref25","unstructured":"National Institutes of Health and National Cancer Institute. Common Terminology Criteria for Adverse Events (CTCAE) Version 5.0: U.S. Department of Health and Human Service. 2017. Available at: https:\/\/dctd.cancer.gov\/research\/ctep-trials\/for-sites\/adverse-events\/ctcae-v5-5x7.pdf (Accessed: 20 May 2026)."},{"key":"ref26","doi-asserted-by":"publisher","unstructured":"Fan L, Han XR, Liu Z, Liu SJ, Zhang DL. Effectiveness of sodium ferulate combined with mecobalamin in treatment of diabetic peripheral neuropathy. Neural Injury and Functional Reconstruction. 2020; 15: 335\u2013336.  (In Chinese)","DOI":"10.16780\/j.cnki.sjssgncj.20191452"},{"key":"ref27","doi-asserted-by":"publisher","unstructured":"Aaronson NK, Ahmedzai S, Bergman B, Bullinger M, Cull A, Duez NJ, et al. The European Organization for Research and Treatment of Cancer QLQ-C30: a quality-of-life instrument for use in international clinical trials in oncology. Journal of the National Cancer Institute. 1993; 85: 365\u2013376.","DOI":"10.1093\/jnci\/85.5.365"},{"key":"ref28","unstructured":"Amin MB, Edge SB, Greene FL, Byrd DR, Brookland RK, Washington MK, et al. AJCC Cancer Staging Manual. 8th ed. Springer: New York. 2017."},{"key":"ref29","doi-asserted-by":"publisher","unstructured":"Hsieh YL, Lu YL, Yang NP, Yang CC. Methylcobalamin in Combination with Early Intervention of Low-Intensity Pulsed Ultrasound Potentiates Nerve Regeneration and Functional Recovery in a Rat Brachial Plexus Injury Model. International Journal of Molecular Sciences. 2023; 24: 13856.","DOI":"10.3390\/ijms241813856"},{"key":"ref30","doi-asserted-by":"publisher","unstructured":"Liu J, Guan Y, Yang L, Fang H, Sun H, Sun Y, et al. Ferulic Acid as an Anti-Inflammatory Agent: Insights into Molecular Mechanisms, Pharmacokinetics and Applications. Pharmaceuticals. 2025; 18: 912.","DOI":"10.3390\/ph18060912"},{"key":"ref31","doi-asserted-by":"publisher","unstructured":"Singh S, Arthur R, Upadhayay S, Kumar P. Ferulic acid ameliorates neurodegeneration via the Nrf2\/ARE signalling pathway: A Review. Pharmacological Research-Modern Chinese Medicine. 2022; 5: 100190.","DOI":"10.1016\/j.prmcm.2022.100190"},{"key":"ref32","doi-asserted-by":"publisher","unstructured":"Xiong ZL, Wang Y, Ma XL, Zhou C, Jiang XW, Yu WH. Based on proteomics to explore the mechanism of mecobalamin promoting the repair of injured peripheral nerves. Canadian Journal of Physiology and Pharmacology. 2022; 100: 562\u2013572.","DOI":"10.1139\/cjpp-2021-0692"},{"key":"ref33","doi-asserted-by":"publisher","unstructured":"Zhang D, Jing B, Chen ZN, Li X, Shi HM, Zheng YC, et al. Ferulic acid alleviates sciatica by inhibiting neuroinflammation and promoting nerve repair via the TLR4\/NF-\u03baB pathway. CNS Neuroscience & Therapeutics. 2023; 29: 1000\u20131011.","DOI":"10.1111\/cns.14060"},{"key":"ref34","doi-asserted-by":"publisher","unstructured":"van Haren FGAM, Steegers MAH, Thijssen M, van der Wal SEI, Vissers KCP, Engels Y. Qualitative Evaluation of the Influence of Acute Oxaliplatin-Induced Peripheral Neuropathy on Quality of Life and Activities of Daily Life. Pain Practice. 2021; 21: 513\u2013522.","DOI":"10.1111\/papr.12981"},{"key":"ref35","doi-asserted-by":"publisher","unstructured":"Tu\u011fral A, Kebabc\u0131 E, Ar\u0131ba\u015f Z, Akyol M, Can A, Bakar Y. Quality of life and somatic physical function of patients with colorectal cancer who underwent oxaliplatin-based systemic chemotherapy: a prospective study. Supportive Care in Cancer. 2024; 32: 734.","DOI":"10.1007\/s00520-024-08937-x"}],"container-title":["British Journal of Hospital Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.imrpress.com\/journal\/BJHM\/87\/6\/10.31083\/BJHM55138","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,7]],"date-time":"2026-07-07T10:57:36Z","timestamp":1783421856000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.imrpress.com\/journal\/BJHM\/87\/6\/10.31083\/BJHM55138"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,6,22]]},"references-count":35,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2026]]}},"alternative-id":["S1750-8460(26)03045-0"],"URL":"https:\/\/doi.org\/10.31083\/bjhm55138","relation":{},"ISSN":["1750-8460","1759-7390"],"issn-type":[{"value":"1750-8460","type":"print"},{"value":"1759-7390","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,6,22]]},"article-number":"55138"}}