{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T12:15:19Z","timestamp":1788437719315,"version":"build-2803163510"},"reference-count":36,"publisher":"IMR Press","issue":"8","license":[{"start":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T00:00:00Z","timestamp":1786924800000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Br. J. Hosp. Med. (Lond)"],"abstract":"<jats:p>Aims\/Background:Anemia is a highly prevalent and clinically significant complication in maintenance hemodialysis (MHD) patients, markedly impairing quality of life and being associated with adverse prognosis. Conventional management strategies often lack sufficient individualization, potentially leading to suboptimal therapeutic outcomes. This study aimed to investigate the impact of personalized anemia management on quality of life and albumin levels in maintenance hemodialysis patients through a retrospective analysis.Methods:A retrospective analysis was conducted involving 353 patients who received maintenance hemodialysis at the Affiliated Hospital of North Sichuan Medical College between March 2022 and March 2025. Based on the management approaches documented in their medical records, patients were divided into two groups: Those receiving routine medical care were assigned to the control group (n = 181), while those receiving personalized anemia management strategies were assigned to the observation group (n = 172). The observation group received personalized anemia management in addition to routine dialysis. Specifically, this approach included individualized adjustment of erythropoietin and iron dosages based on a comprehensive evaluation of dynamic hemoglobin and albumin levels, as well as nutritional status. Meanwhile, a multidisciplinary team led by physicians collaboratively formulated nutritional and pharmacological management plans and provided adherence guidance. The study compared changes in hemoglobin levels, hemoglobin target achievement rate, albumin levels, body composition parameters, Self-Rating Anxiety Scale (SAS), Self-Rating Depression Scale (SDS), quality of life scores (assessed using the Kidney Disease Quality of Life 36-Item Short Form Survey, KDQOL-36), and Pittsburgh Sleep Quality Index (PSQI) between the two groups before and after treatment.Results:Following the intervention, depression and anxiety scores in the observation group were significantly lower than those in the control group (p &lt; 0.05). Regarding physiological indicators, albumin levels, body composition parameters, hemoglobin levels, and the hemoglobin target achievement rate, the observation group showed significant improvements compared with the control group (p &lt; 0.05). Additionally, the PSQI score was significantly lower in the observation group, whereas the quality of life scores were significantly higher compared with the control group; all differences were statistically significant (p &lt; 0.05).Conclusion:Personalized anemia management significantly improves quality of life and albumin levels in maintenance hemodialysis patients and demonstrates potential for clinical application.<\/jats:p>","DOI":"10.31083\/bjhm57141","type":"journal-article","created":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T11:29:22Z","timestamp":1788434962000},"source":"Crossref","is-referenced-by-count":0,"title":["Impact of Personalized Anemia Management on Quality of Life and Serum Albumin Levels in Maintenance Hemodialysis Patients"],"prefix":"10.31083","volume":"87","author":[{"ORCID":"https:\/\/orcid.org\/0009-0005-8165-267X","authenticated-orcid":true,"given":"Kun","family":"Yang","sequence":"first","affiliation":[{"name":"Department of Nephrology, Affiliated Hospital of North Sichuan Medical College, 637000 Nanchong, Sichuan, China"},{"name":"School of Graduate Studies (SGS), Postgraduate Centre, Management and Science University, Shah Alam, SGR 40100, Malaysia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heping","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Nephrology, Affiliated Hospital of North Sichuan Medical College, 637000 Nanchong, Sichuan, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenxu","family":"Pan","sequence":"additional","affiliation":[{"name":"Department of the First Internal Medicine, The Second Naval Hospital of Southern Theater Command of PLA, 572022 Sanya, Hainan, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Imad Ibrahim Ali","family":"Al-Sultan","sequence":"additional","affiliation":[{"name":"International Medical School, Management and Science University, Shah Alam, SGR 40100, Malaysia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"16242","published-online":{"date-parts":[[2026,8,17]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","unstructured":"Kalantar-Zadeh K, Jafar TH, Nitsch D, Neuen BL, Perkovic V. Chronic kidney disease. Lancet (London, England). 2021; 398: 786\u2013802.","DOI":"10.1016\/S0140-6736(21)00519-5"},{"key":"ref2","doi-asserted-by":"publisher","unstructured":"Chesnaye NC, Ortiz A, Zoccali C, Stel VS, Jager KJ. The impact of population ageing on the burden of chronic kidney disease. Nature Reviews. Nephrology. 2024; 20: 569\u2013585.","DOI":"10.1038\/s41581-024-00863-9"},{"key":"ref3","doi-asserted-by":"publisher","unstructured":"Wang L, Xu X, Zhang M, Hu C, Zhang X, Li C, et al. Prevalence of Chronic Kidney Disease in China: Results From the Sixth China Chronic Disease and Risk Factor Surveillance. JAMA Internal Medicine. 2023; 183: 298\u2013310.","DOI":"10.1001\/jamainternmed.2022.6817"},{"key":"ref4","doi-asserted-by":"publisher","unstructured":"Fidan C, A\u011f\u0131rba\u015f \u0130. The effect of renal replacement therapy on health-related quality of life in end-stage renal disease: a meta-analysis. Clinical and Experimental Nephrology. 2023; 27: 829\u2013846.","DOI":"10.1007\/s10157-023-02377-3"},{"key":"ref5","doi-asserted-by":"publisher","unstructured":"Portol\u00e9s J, Mart\u00edn L, Broseta JJ, Cases A. Anemia in Chronic Kidney Disease: From Pathophysiology and Current Treatments, to Future Agents. Frontiers in Medicine. 2021; 8: 642296.","DOI":"10.3389\/fmed.2021.642296"},{"key":"ref6","doi-asserted-by":"publisher","unstructured":"Agarwal AK. Iron metabolism and management: focus on chronic kidney disease. Kidney International Supplements. 2021; 11: 46\u201358.","DOI":"10.1016\/j.kisu.2020.12.003"},{"key":"ref7","unstructured":"World Health Organization. Guideline on haemoglobin cutoffs to define anaemia in individuals and populations. In. World Health Organization: Amsterdam. 2024."},{"key":"ref8","doi-asserted-by":"publisher","unstructured":"Huang L, Zhang Y, Wang J, Tang H, Zhou J. Association of anemia and cognitive impairment in patients undergoing maintenance hemodialysis: a cross-sectional study. BMC Nephrology. 2025; 26: 387.","DOI":"10.1186\/s12882-025-04336-4"},{"key":"ref9","doi-asserted-by":"crossref","unstructured":"Shah HH, Fishbane S. Anemia and its treatment in patients with end-stage kidney disease. Handbook of Dialysis Therapy (pp. 341\u2013350). Elsevier: Philadelphia. 2023.","DOI":"10.1016\/B978-0-323-79135-9.00037-9"},{"key":"ref10","doi-asserted-by":"publisher","unstructured":"Zoccali C, Mallamaci F, Adamczak M, de Oliveira RB, Massy ZA, Sarafidis P, et al. Cardiovascular complications in chronic kidney disease: a review from the European Renal and Cardiovascular Medicine Working Group of the European Renal Association. Cardiovascular Research. 2023; 119: 2017\u20132032.","DOI":"10.1093\/cvr\/cvad083"},{"key":"ref11","doi-asserted-by":"crossref","unstructured":"Parker MM, Wigger M. Cardiorenal Syndrome, Chronic Kidney Disease, Anemia, and Heart Failure. Managing Heart Failure in Primary Care: A Case Study Approach (pp. 157\u2013175). Springer: Cham. 2023.","DOI":"10.1007\/978-3-031-20193-6_11"},{"key":"ref12","doi-asserted-by":"publisher","unstructured":"Karaboyas A, Morgenstern H, Waechter S, Fleischer NL, Vanholder R, Jacobson SH, et al. Low hemoglobin at hemodialysis initiation: an international study of anemia management and mortality in the early dialysis period. Clinical Kidney Journal. 2019; 13: 425\u2013433.","DOI":"10.1093\/ckj\/sfz065"},{"key":"ref13","doi-asserted-by":"publisher","unstructured":"Dasgupta I, Bagnis CI, Floris M, Furuland H, Zurro DG, Gesualdo L, et al. Anaemia and quality of life in chronic kidney disease: a consensus document from the European Anaemia of CKD Alliance. Clinical Kidney Journal. 2024; 17: sfae205.","DOI":"10.1093\/ckj\/sfae205"},{"key":"ref14","doi-asserted-by":"publisher","unstructured":"Alshogran OY, Shatnawi EA, Altawalbeh SM, Jarab AS, Farah RI. Predictors of poor health-related quality of life among hemodialysis patients with anemia in Jordan. Health and Quality of Life Outcomes. 2021; 19: 272.","DOI":"10.1186\/s12955-021-01905-7"},{"key":"ref15","doi-asserted-by":"publisher","unstructured":"Badura K, Janc J, W\u0105sik J, Gnitecki S, Skwira S, M\u0142ynarska E, et al. Anemia of Chronic Kidney Disease-A Narrative Review of Its Pathophysiology, Diagnosis, and Management. Biomedicines. 2024; 12: 1191.","DOI":"10.3390\/biomedicines12061191"},{"key":"ref16","doi-asserted-by":"publisher","unstructured":"Clemmer JS, Shafi T, Obi Y. Physiological Mechanisms of Hypertension and Cardiovascular Disease in End-Stage Kidney Disease. Current Hypertension Reports. 2022; 24: 413\u2013424.","DOI":"10.1007\/s11906-022-01203-7"},{"key":"ref17","doi-asserted-by":"publisher","unstructured":"Zhao X, Ma C, Gan L, Hou FF, Liang X, Chen X, et al. Current clinical profiles for Chinese hemodialysis patients. Scientific Reports. 2025; 15: 28428.","DOI":"10.1038\/s41598-025-11951-6"},{"key":"ref18","doi-asserted-by":"publisher","unstructured":"Fuertinger DH, Wang LC, J\u00f6rg DJ, Rivera Fuentes L, Ye X, Casper S, et al. Effects of Individualized Anemia Therapy on Hemoglobin Stability: A Randomized Controlled Pilot Trial in Patients on Hemodialysis. Clinical Journal of the American Society of Nephrology: CJASN. 2024; 19: 1138\u20131147.","DOI":"10.2215\/CJN.0000000000000488"},{"key":"ref19","doi-asserted-by":"publisher","unstructured":"Song H, Wei C, Hu H, Wan Q. Association of the serum albumin level with prognosis in chronic kidney disease patients. International Urology and Nephrology. 2022; 54: 2421\u20132431.","DOI":"10.1007\/s11255-022-03140-5"},{"key":"ref20","doi-asserted-by":"publisher","unstructured":"Cheng T, Wang X, Han Y, Hao J, Hu H, Hao L. The level of serum albumin is associated with renal prognosis and renal function decline in patients with chronic kidney disease. BMC Nephrology. 2023; 24: 57.","DOI":"10.1186\/s12882-023-03110-8"},{"key":"ref21","doi-asserted-by":"publisher","unstructured":"Tonelli M, Berns JS, Bozkurt B, Cheung RS, Cuevas Y, Effa EE, et al. KDIGO 2026 Clinical Practice Guideline for the Management of Anemia in Chronic Kidney Disease (CKD). Kidney International. 2026; 109: S1\u2013S99.","DOI":"10.1016\/j.kint.2025.06.006"},{"key":"ref22","unstructured":"Kidney Disease: Improving Global Outcomes (KDIGO) Anemia Work Group. KDIGO Clinical Practice Guideline for Anemia in Chronic Kidney Disease. Kidney International Supplements. 2012; 2: 279\u2013335."},{"key":"ref23","doi-asserted-by":"publisher","unstructured":"Zung WW. A rating instrument for anxiety disorders. Psychosomatics. 1971; 12: 371\u2013379.","DOI":"10.1016\/S0033-3182(71)71479-0"},{"key":"ref24","doi-asserted-by":"publisher","unstructured":"Zung WW, Richards CB, Short MJ. Self-rating depression scale in an outpatient clinic. Further validation of the SDS. Archives of General Psychiatry. 1965; 13: 508\u2013515.","DOI":"10.1001\/archpsyc.1965.01730060026004"},{"key":"ref25","doi-asserted-by":"publisher","unstructured":"Moist LM, Troyanov S, White CT, Wazny LD, Wilson JA, McFarlane P, et al. Canadian Society of Nephrology commentary on the 2012 KDIGO Clinical Practice Guideline for Anemia in CKD. American Journal of Kidney Diseases. 2013; 62: 860\u2013873.","DOI":"10.1053\/j.ajkd.2013.08.001"},{"key":"ref26","doi-asserted-by":"publisher","unstructured":"Hays RD, Kallich JD, Mapes DL, Coons SJ, Carter WB. Development of the kidney disease quality of life (KDQOLTM) instrument. Quality of Life Research: An International Journal of Quality of Life Aspects of Treatment, Care and Rehabilitation. 1994; 3: 329\u2013338.","DOI":"10.1007\/BF00451725"},{"key":"ref27","doi-asserted-by":"publisher","unstructured":"Buysse DJ, Reynolds CF III, Monk TH, Berman SR, Kupfer DJ. The Pittsburgh Sleep Quality Index: a new instrument for psychiatric practice and research. Psychiatry Research. 1989; 28: 193\u2013213.","DOI":"10.1016\/0165-1781(89)90047-4"},{"key":"ref28","doi-asserted-by":"publisher","unstructured":"Yakupova EI, Abramicheva PA, Bocharnikov AD, Andrianova NV, Plotnikov EY. Biomarkers of the End-Stage Renal Disease Progression: Beyond the GFR. Biochemistry. Biokhimiia. 2023; 88: 1622\u20131644.","DOI":"10.1134\/S0006297923100164"},{"key":"ref29","doi-asserted-by":"publisher","unstructured":"Ebert T, Neytchev O, Witasp A, Kublickiene K, Stenvinkel P, Shiels PG. Inflammation and Oxidative Stress in Chronic Kidney Disease and Dialysis Patients. Antioxidants & Redox Signaling. 2021; 35: 1426\u20131448.","DOI":"10.1089\/ars.2020.8184"},{"key":"ref30","doi-asserted-by":"publisher","unstructured":"Wittbrodt ET, James G, Kumar S, van Haalen H, Chen H, Sloand JA, et al. Contemporary outcomes of anemia in US patients with chronic kidney disease. Clinical Kidney Journal. 2022; 15: 244\u2013252.","DOI":"10.1093\/ckj\/sfab195"},{"key":"ref31","doi-asserted-by":"publisher","unstructured":"Habas E Sr, Al Adab A, Arryes M, Alfitori G, Farfar K, Habas AM, et al. Anemia and Hypoxia Impact on Chronic Kidney Disease Onset and Progression: Review and Updates. Cureus. 2023; 15: e46737.","DOI":"10.7759\/cureus.46737"},{"key":"ref32","doi-asserted-by":"publisher","unstructured":"Pramod S, Goldfarb DS. Challenging patient phenotypes in the management of anaemia of chronic kidney disease. International Journal of Clinical Practice. 2021; 75: e14681.","DOI":"10.1111\/ijcp.14681"},{"key":"ref33","doi-asserted-by":"publisher","unstructured":"Flythe JE, Watnick S. Dialysis for Chronic Kidney Failure: A Review. JAMA. 2024; 332: 1559\u20131573.","DOI":"10.1001\/jama.2024.16338"},{"key":"ref34","doi-asserted-by":"publisher","unstructured":"Gela YY, Limenh LW, Simegn W, Ayenew W, Chanie GS, Seid AM, et al. Poor sleep quality and associated factors among adult chronic kidney disease patients. Frontiers in Medicine. 2024; 11: 1366010.","DOI":"10.3389\/fmed.2024.1366010"},{"key":"ref35","doi-asserted-by":"publisher","unstructured":"Gregg LP, Bossola M, Ostrosky-Frid M, Hedayati SS. Fatigue in CKD: Epidemiology, Pathophysiology, and Treatment. Clinical Journal of the American Society of Nephrology: CJASN. 2021; 16: 1445\u20131455.","DOI":"10.2215\/CJN.19891220"},{"key":"ref36","doi-asserted-by":"publisher","unstructured":"Zhang L, Zou L, Zhou L. Effectiveness of psychoeducational interventions on psychological distress and health-related quality of life among patients with maintenance hemodialysis: a systematic review and meta-analysis. Renal Failure. 2024; 46: 2331613.","DOI":"10.1080\/0886022X.2024.2331613"}],"container-title":["British Journal of Hospital Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.imrpress.com\/journal\/BJHM\/87\/8\/10.31083\/BJHM57141","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T11:29:42Z","timestamp":1788434982000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.imrpress.com\/journal\/BJHM\/87\/8\/10.31083\/BJHM57141"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8,17]]},"references-count":36,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2026]]}},"alternative-id":["S1750-8460(26)03540-0"],"URL":"https:\/\/doi.org\/10.31083\/bjhm57141","relation":{},"ISSN":["1750-8460","1759-7390"],"issn-type":[{"value":"1750-8460","type":"print"},{"value":"1759-7390","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,8,17]]},"article-number":"57141"}}