{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,21]],"date-time":"2026-01-21T03:22:53Z","timestamp":1768965773629,"version":"3.49.0"},"reference-count":29,"publisher":"IMR Press","issue":"2","license":[{"start":{"date-parts":[[2025,4,9]],"date-time":"2025-04-09T00:00:00Z","timestamp":1744156800000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Front. Biosci. (Elite Ed)"],"abstract":"<jats:p>The oral cavity is a complex ecosystem that harbors a diverse microbial community. Viral infections can significantly disrupt this delicate balance, leading to various oral health issues. This review delves into the intricate relationship between viruses and oral health, exploring the impact of both RNA and DNA viruses. We discuss the mechanisms through which these viruses influence the oral microbiome, modulate immune responses, and contribute to various oral diseases, including periodontal disease, oral candidiasis, and oral cancer. Additionally, we highlight the potential of saliva as a valuable diagnostic tool for viral infections and oral health assessment. By understanding the viral\u2013oral health nexus, we can develop effective strategies for prevention, early diagnosis, and targeted interventions to improve oral health outcomes.<\/jats:p>","DOI":"10.31083\/fbe33494","type":"journal-article","created":{"date-parts":[[2025,7,2]],"date-time":"2025-07-02T05:21:47Z","timestamp":1751433707000},"source":"Crossref","is-referenced-by-count":3,"title":["Viral Invasion of the Oral Cavity: A Review of Viral Impact on Oral Health and the Potential Use of Saliva as a Diagnostic Tool"],"prefix":"10.31083","volume":"17","author":[{"given":"Senthilraj","family":"Rajapandi","sequence":"first","affiliation":[{"name":"Department of Pharmaceutical Biotechnology, Faculty of Pharmacy, Dr.M.G.R. Educational and Research Institute, Velappanchavadi, 600077 Chennai, Tamil Nadu, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4170-9855","authenticated-orcid":true,"given":"Evelyn Sharon","family":"Sukumaran","sequence":"first","affiliation":[{"name":"Department of Pharmacology, Faculty of Pharmacy, Dr.M.G.R. Educational and Research Institute, Velappanchavadi, 600077 Chennai, Tamil Nadu, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Keerthanashree Reddy Napa","family":"Prasad","sequence":"first","affiliation":[{"name":"Department of Pharmacology, Faculty of Pharmacy, Dr.M.G.R. Educational and Research Institute, Velappanchavadi, 600077 Chennai, Tamil Nadu, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anushya Vardhini","family":"Venkatesan","sequence":"first","affiliation":[{"name":"Department of Pharmacology, Faculty of Pharmacy, Dr.M.G.R. 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Educational and Research Institute, Velappanchavadi, 600077 Chennai, Tamil Nadu, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0792-392X","authenticated-orcid":true,"given":"Sarvesh","family":"Sabarathinam","sequence":"first","affiliation":[{"name":"Center for Global Health Research, Saveetha Medical College and Hospitals, Saveetha Institute of Medical and Technical Sciences (SIMATS), Saveetha University, 602105 Chennai, Tamil Nadu, India"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"16242","published-online":{"date-parts":[[2025,4,9]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","unstructured":"Deo PN, Deshmukh R. Oral microbiome: Unveiling the fundamentals. Journal of Oral and Maxillofacial Pathology. 2019; 23: 122\u2013128.","DOI":"10.4103\/jomfp.JOMFP_304_18"},{"key":"ref2","doi-asserted-by":"publisher","unstructured":"Durmu\u015f S, \u00dclgen K\u00d6. 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