{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T22:46:34Z","timestamp":1775083594808,"version":"3.50.1"},"reference-count":23,"publisher":"IMR Press","issue":"1","license":[{"start":{"date-parts":[[2025,1,22]],"date-time":"2025-01-22T00:00:00Z","timestamp":1737504000000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Cisen Pharmaceutical Public COVID-19 Scientific Research Fund","award":["WPV01-CP-23"],"award-info":[{"award-number":["WPV01-CP-23"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Front. Biosci. (Landmark Ed)"],"abstract":"<jats:p>Background: Dexamethasone has proven life-saving in severe acute respiratory syndrome (SARS) and COVID-19 cases. However, its systemic administration is accompanied by serious side effects. Inhalation delivery of dexamethasone (Dex) faces challenges such as low lung deposition, brief residence in the respiratory tract, and the pulmonary mucus barrier, limiting its clinical use. Neutrophil cell membrane-derived nanovesicles, with their ability to specifically target hyper-activated immune cells and excellent mucus permeability, emerge as a promising carrier for pulmonary inhalation therapy. Methods: We designed a novel UiO66 metal-organic framework nanoparticle loaded with Dex and coated with neutrophil cell membranes (UiO66-Dex@NMP) for targeted therapy of severe pneumonia. This was achieved by loading Dex into UiO66 pores and subsequently coating with neutrophil membranes for functionalization. Results: Drug release experiments revealed UiO66-Dex@NMP to exhibit favorable sustained-release properties. Additionally, UiO66-Dex@NMP demonstrated excellent targeting capabilities both in vitro and in vivo. In a mouse model of lipopolysaccharide (LPS)-induced pneumonia, UiO66-Dex@NMP significantly reduced lung inflammation compared to both the control model and Dex administered via inhalation. Histopathological analysis further confirmed UiO66-Dex@NMP\u2019s ability to alleviate lung tissue damage. Conclusions: UiO66-Dex@NMP represents a novel and safe inhaled delivery carrier for Dex, offering valuable insights into the clinical management of respiratory diseases, including severe pneumonia.<\/jats:p>","DOI":"10.31083\/fbl26721","type":"journal-article","created":{"date-parts":[[2025,1,25]],"date-time":"2025-01-25T08:54:32Z","timestamp":1737795272000},"source":"Crossref","is-referenced-by-count":8,"title":["Atomized Neutrophil Membrane-coated MOF Nanoparticles for Direct Delivery of Dexamethasone for Severe Pneumonia"],"prefix":"10.31083","volume":"30","author":[{"given":"Yixiao","family":"Yang","sequence":"first","affiliation":[{"name":"Institute of Translational Medicine, Shanghai University, 200444 Shanghai, China"},{"name":"Institute of Burn Research, The First Affiliated Hospital, State Key Lab of Trauma, Burn and Combined Injury, Chongqing Key Laboratory for Disease Proteomics, Third Military Medical University (Army Medical University), 400038 Chongqing, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lizhen","family":"Yan","sequence":"first","affiliation":[{"name":"Department of Respiratory and Critical Care Medicine, Zibo Municipal Hospital, 255400 Zibo, Shandong, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Han","family":"Zhang","sequence":"first","affiliation":[{"name":"Institute of Translational Medicine, Shanghai University, 200444 Shanghai, China"},{"name":"MPA Key Laboratory for Research and Evaluation of Tissue Engineering Technology Products, Medical College, Nantong University, 226001 Nantong, Jiangsu, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chuanguang","family":"Xiao","sequence":"first","affiliation":[{"name":"Department of Breast Thyroid Surgery, Zibo Central Hospital, 255036 Zibo, Shandong, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1373-579X","authenticated-orcid":true,"given":"Kai","family":"Wang","sequence":"first","affiliation":[{"name":"Institute of Translational Medicine, Shanghai University, 200444 Shanghai, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"16242","published-online":{"date-parts":[[2025,1,22]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","unstructured":"de Benedictis FM, Kerem E, Chang AB, Colin AA, Zar HJ, Bush A. 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